Protein detail
BMX
Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)
Entry name BMX | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification EnzymesPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)
Protein Class (2)
EnzymesPredicted intracellular proteins
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Kinases:Tyr protein kinases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
ETKPSCTK3
Gene Description
BMX non-receptor tyrosine kinase
Chromosome
X
Position
15464246-15556529
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization2
Cell SpecificNeutrophils
Function & Pathway6
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Kinases:Tyr protein kinases
- Predicted intracellular proteins
Cellular Component (4)
Molecular Function (5)
Biological Process (3)
Reactome (8)
Mediation Categories (2)
Immune mediationMetabolism mediation
Relations & Evidence68
Enzyme-Mediated Modification (16)
16 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| BMX | DYRK4 | Q9NR20 | Y | 216 | phosphorylation | PhosphoNetworks | |
| BMX | FGFR4 | P22455 | Y | 216 | phosphorylation | PhosphoNetworks | |
| BMX | PTK2 | Q05397 | Y | 40 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA | KEA:11331870 |
| BMX | EGF | P01133 | Y | 40 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17823122 |
| BMX | IGF1R | P08069 | Y | 224 | phosphorylation | KEA | KEA:17570479 |
| BMX | INSR | P06213 | Y | 566 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network (11)
11 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| BMX | P51813 | BAK | Q16611 | Yes | No | No | Sparser_ProtMapperiPTMnetProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:26909357ProtMapper:25649765PhosphoSite:23189150PhosphoSite:25649765PhosphoSite:20959805 |
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Protein Complex Composition (33)
33 records.
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 39066974 |
Sequence, Structure & Domains13
Sequences
Length
675
Mass
78,011
Sequence
MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH
3D Structural Models
Turn
437..439; 505..507; 607..609; 612..615
Helix
303..312; 370..379; 414..416; 454..466; 497..504; 510..529; 539..541; 557..560; 576..578; 581..586; 591..606; 618..626; 639..647; 653..655; 659..666; 667..669
Beta Strand
129..133; 136..139; 294..297; 318..323; 330..334; 347..350; 359..362; 383..385; 417..426; 429..436; 440..447; 475..479; 481..490; 532..536; 542..544; 550..552; 566..568; 587..590
3D Structure
NMR spectroscopy (2); X-ray crystallography (4)
Domain & Motif Annotations
Motif
596..603; CAV1-binding
Zinc Finger
113..149; Btk-type
Domain (CC)
SH2 domain mediates interaction with RUFY1..
Domain (FT)
4..111; PH; 296..392; SH2; 417..675; Protein kinase
Protein Families (3)
- Protein kinase superfamily
- Tyr protein kinase family
- TEC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Clinical Relevance5
Interaction Protein (2)
ENSG00000070778ENSG00000168610
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37554265 | BCR-ABL1-driven exosome-miR130b-3p-mediated gap-junction Cx43 MSC intercellular communications imply therapies of leukemic subclonal evolution. | No abstract available |