Protein detail

BMX

Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)

Entry name BMX	UniProt ID P51813	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)

Protein Class

EnzymesPredicted intracellular proteins

Protein Function

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases
Predicted intracellular proteins

Ensembl

ENSG00000102010

Entrez Gene Symbol

BMX

Gene Synonym

ETKPSCTK3

Gene Description

BMX non-receptor tyrosine kinase

Chromosome

Position

15464246-15556529

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificNeutrophils

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Immune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

16 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
BMX	BTK	Q06187	Y	216	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:12573241 SIGNOR:12573241 ProtMapper:12573241 phosphoELM:12573241
BMX	BTK	Q06187	Y	224	phosphorylation	PhosphoNetworksphosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapper	KEA:12573241 SIGNOR:12573241 ProtMapper:12573241 phosphoELM:12573241
BMX	TEC	P42680	Y	224	phosphorylation	phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapper	KEA:12573241 SIGNOR:12573241 ProtMapper:12573241 phosphoELM:12573241
BMX	TEC	P42680	Y	216	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:12573241 SIGNOR:12573241 ProtMapper:12573241
BMX	SRC	P12931	Y	566	phosphorylation	BEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperdbPTMKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:10688651 dbPTM:10688651 ProtMapper:10688651 SIGNOR:10688651 KEA:17570479 phosphoELM:10688651
BMX	ITK	Q08881	Y	224	phosphorylation	phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper	KEA:12573241 SIGNOR:12573241 ProtMapper:12573241
BMX	ITK	Q08881	Y	216	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:12573241 SIGNOR:12573241 ProtMapper:12573241
BMX	PTPRG	P23470	Y	40	dephosphorylation	SIGNOR	SIGNOR:25624455
BMX	PTPRG	P23470	Y	40	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:25624455
BMX	CASP3	P42574	D	242	cleavage	HPRD	HPRD:11278797

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Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

11 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
BMX	P51813	BAK	Q16611	Yes	No	No	Sparser_ProtMapperiPTMnetProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:26909357 ProtMapper:25649765 PhosphoSite:23189150 PhosphoSite:25649765 PhosphoSite:20959805

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Protein Complex Composition

33 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
APOBEC3B DAZL ELAVL1 ELAVL2 ELAVL3 HNRNPCL1 IGF2BP2 PUM2 RBM6 RBMS2 RBMXL1 RO60 SUGP2 TAF15 TOP3B	O60812 O95985 P10155 P78332 Q12926 Q14576 Q15434 Q15717 Q8IX01 Q8TB72 Q92804 Q92904 Q96E39 Q9UH17 Q9Y6M1	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
CDC5L KIN PHF5A RBMX2 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SF3B5 SF3B6 SNIP1 SRRM1	O60870 O75533 Q12874 Q13435 Q15393 Q15427 Q15428 Q7RTV0 Q8IYB3 Q8TAD8 Q99459 Q9BWJ5 Q9Y388 Q9Y3B4	1:1:1:1:1:1:1:1:1:1:1:1:1:1	PDB	PDB:7abh
FDXACB1 RABGGTA RBMXL2	O75526 Q92696 Q9BRP7	0:0:0	Havugimana2012	Havugimana2012:C_131
AVP KRTAP13-2 NIF3L1 RBMX ZNF326	P01185 P38159 Q52LG2 Q5BKZ1 Q9GZT8	0:0:0:0:0	hu.MAP2
HNRNPK HNRNPL LDHB RBMX	P07195 P14866 P38159 P61978	0:0:0:0	hu.MAP2
CDKN2AIP CDKN2AIPNL RBMX TMPO XRN2	P38159 P42166 Q96HQ2 Q9H0D6 Q9NXV6	0:0:0:0:0	hu.MAP2
CDKN2AIP CDKN2AIPNL RBMX TMPO XRN2	P38159 P42167 Q96HQ2 Q9H0D6 Q9NXV6	0:0:0:0:0	hu.MAP2
APOBEC3B NCOA5 RBM12B RBMX RBMXL1 SAFB2 TAF15 TWNK YLPM1 ZNF326 ZNF638	P38159 P49750 Q14151 Q14966 Q5BKZ1 Q8IXT5 Q92804 Q96E39 Q96RR1 Q9HCD5 Q9UH17	0:0:0:0:0:0:0:0:0:0:0	hu.MAP
NCOA5 RBM12B RBMX RBMXL1 SAFB2 YLPM1 ZNF326 ZNF638	P38159 P49750 Q14151 Q14966 Q5BKZ1 Q8IXT5 Q96E39 Q9HCD5	0:0:0:0:0:0:0:0	hu.MAP
NCOA5 RBM12B RBMX TWNK YLPM1 ZNF638	P38159 P49750 Q14966 Q8IXT5 Q96RR1 Q9HCD5	0:0:0:0:0:0	hu.MAP

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	39066974

Sequence, Structure & Domains

Sequences

Length

675

Mass

78,011

Sequence

MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH

3D Structural Models

Turn

437..439; 505..507; 607..609; 612..615

Helix

303..312; 370..379; 414..416; 454..466; 497..504; 510..529; 539..541; 557..560; 576..578; 581..586; 591..606; 618..626; 639..647; 653..655; 659..666; 667..669

Beta Strand

129..133; 136..139; 294..297; 318..323; 330..334; 347..350; 359..362; 383..385; 417..426; 429..436; 440..447; 475..479; 481..490; 532..536; 542..544; 550..552; 566..568; 587..590

3D Structure

NMR spectroscopy (2); X-ray crystallography (4)

Domain & Motif Annotations

Motif

596..603; CAV1-binding

Zinc Finger

113..149; Btk-type

Domain (CC)

SH2 domain mediates interaction with RUFY1..

Domain (FT)

4..111; PH; 296..392; SH2; 417..675; Protein kinase

Protein Families

Protein kinase superfamily
Tyr protein kinase family
TEC subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

Clinical Relevance

Drugs

CHLOROQUINE PF-06651600 PD-168393 CANERTINIB IBRUTINIB

Antibody

HPA001048 CAB032495

Interaction Protein

ENSG00000070778ENSG00000168610

Interaction Count

Interaction Dataset

intact_biogrid