Protein detail

BMX

Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)

Entry name BMX	UniProt ID P51813	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)

Protein Class

EnzymesPredicted intracellular proteins

Protein Function

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases
Predicted intracellular proteins

Ensembl

ENSG00000102010

Entrez Gene Symbol

BMX

Gene Synonym

ETKPSCTK3

Gene Description

BMX non-receptor tyrosine kinase

Chromosome

Position

15464246-15556529

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificNeutrophils

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Immune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

16 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
BMX	DYRK4	Q9NR20	Y	216	phosphorylation	PhosphoNetworks
BMX	FGFR4	P22455	Y	216	phosphorylation	PhosphoNetworks
BMX	PTK2	Q05397	Y	40	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:11331870
BMX	EGF	P01133	Y	40	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17823122
BMX	IGF1R	P08069	Y	224	phosphorylation	KEA	KEA:17570479
BMX	INSR	P06213	Y	566	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

11 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SRC	P12931	BMX	P51813	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAHPRDWangPhosphoSite_ProtMapperNetworKIN_KEABEL-Large-Corpus_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteSPIKE_LC	KEA:10688651 dbPTM:10688651 ProtMapper:10688651 PhosphoSite:10688651 SIGNOR:10688651 PhosphoSite:27601470 KEA:17570479 HPRD:10688651 phosphoELM:10688651 SPIKE_LC:16189514
BMX	P51813	FAK1	Q05397	Yes	Yes	No	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperHPRDSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperSPIKE_LC	PhosphoSite:20473329 PhosphoSite:21918175 PhosphoSite:18250445 PhosphoSite:15707572 PhosphoSite:25617365 PhosphoSite:16782899 PhosphoSite:20802517 PhosphoSite:12871985 PhosphoSite:18437915 PhosphoSite:20501847 PhosphoSite:16415178 PhosphoSite:29311227 PhosphoSite:32839549 SIGNOR:23716717 PhosphoSite:14761895 PhosphoSite:21454698 PhosphoSite:15561106 PhosphoSite:17117420 PhosphoSite:28053086 PhosphoSite:16153436 PhosphoSite:23466867 PhosphoSite:17088251 ProtMapper:23716717 PhosphoSite:23716717 PhosphoSite:15371459 PhosphoSite:21059620 PhosphoSite:15735019 HPRD:11331870 PhosphoSite:11909938 PhosphoSite:17215324 PhosphoSite:27994061 PhosphoSite:22940691 PhosphoSite:14645233 PhosphoSite:22490227 PhosphoSite:12876384 PhosphoSite:18664639 PhosphoSite:12482769 PhosphoSite:12639965 PhosphoSite:16291744 PhosphoSite:16920701 PhosphoSite:17449913 PhosphoSite:15026417 PhosphoSite:19815712 PhosphoSite:20658524 PhosphoSite:27226554 PhosphoSite:11839772 PhosphoSite:21289086 PhosphoSite:17317726 PhosphoSite:14656986 PhosphoSite:17692050 SPIKE_LC:16189514
BMX	P51813	STAT3	P40763	Yes	Yes	No	WangPhosphoPointSIGNORProtMapperREACH_ProtMapperHPRDHuRIBioGRIDIntActInnateDBSPIKE_LCLit-BM-17	Lit-BM-17:10688651 IntAct:25814554 BioGRID:10688651 IntAct:25416956 IntAct:32296183 IntAct:31515488 ProtMapper:21481791 InnateDB:25416956 ProtMapper:26267517 HPRD:10688651 Lit-BM-17:25814554 SIGNOR:22348200 SPIKE_LC:16189514
BMX	P51813	PAR1	P25116	Yes	No	Yes	SIGNORSparser_ProtMapperProtMapper	SIGNOR:31910739 ProtMapper:31910739
BMX	P51813	RUFY1	Q96T51	Yes	Yes	No	SIGNORProtMapperPhosphoSite_KEAphosphoELM_KEALit-BM-17MPPIHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAphosphoELMSIGNOR_ProtMapperPhosphoSiteSPIKE_LC	SIGNOR:11877430 phosphoELM:11877430 HPRD:11877430 MPPI:11877430 KEA:11877430 PhosphoSite:11877430 Lit-BM-17:11877430 ProtMapper:11877430 SPIKE_LC:16189514
TEC	P42680	BMX	P51813	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper	ProtMapper:12573241 phosphoELM:12573241 KEA:12573241 SIGNOR:12573241 HPRD:12573241
BTK	Q06187	BMX	P51813	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite	ProtMapper:12573241 PhosphoSite:12573241 phosphoELM:12573241 KEA:12573241 SIGNOR:12573241 HPRD:12573241
ITK	Q08881	BMX	P51813	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSite_ProtMapper	KEA:12573241 SIGNOR:12573241 ProtMapper:12573241 HPRD:12573241
BMX	P51813	BCAR1	P56945	Yes	Yes	No	iPTMnetSIGNORProtMapperInnateDBPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:21937722 InnateDB:15207703 SIGNOR:21937722
PTPRG	P23470	BMX	P51813	Yes	No	Yes	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:25624455 ProtMapper:25624455

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Protein Complex Composition

33 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CLK3 RBMX SAFB SRSF1 SRSF2	P38159 P49761 Q01130 Q07955 Q15424	0:0:0:0:0	hu.MAP2
CDC5L HNRNPK KHDRBS1 PCLAF RBMX SNW1	P38159 P61978 Q07666 Q13573 Q15004 Q99459	1:1:1:1:1:1	CompleatCFinder	Compleat:HC6365
APOBEC3B NCOA5 RBMX TAF15 TWNK	P38159 Q92804 Q96RR1 Q9HCD5 Q9UH17	0:0:0:0:0	hu.MAP
H2BC18 MECP2 RBM34 RBMX2 SDAD1	P42696 P51608 Q5QNW6 Q9NVU7 Q9Y388	0:0:0:0:0	hu.MAP2
BMX	P51813	2	PDB	PDB:6i99PDB:3sxr
BMX CC2D1B USP24	P51813 Q5T0F9 Q9UPU5	0:0:0	hu.MAP2
APOBEC3B RBM6 RBMXL1 TAF15	P78332 Q92804 Q96E39 Q9UH17	0:0:0:0	hu.MAP
RBMX2 RRP1B SPTY2D1 ZNF701	Q14684 Q68D10 Q9NV72 Q9Y388	0:0:0:0	hu.MAP2
APOBEC3F RBMXL1 TTC31	Q49AM3 Q8IUX4 Q96E39	0:0:0	hu.MAP2
RBMX2 RSBN1 RSBN1L	Q5VWQ0 Q6PCB5 Q9Y388	0:0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	39066974

Sequence, Structure & Domains

Sequences

Length

675

Mass

78,011

Sequence

MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDKH

3D Structural Models

Turn

437..439; 505..507; 607..609; 612..615

Helix

303..312; 370..379; 414..416; 454..466; 497..504; 510..529; 539..541; 557..560; 576..578; 581..586; 591..606; 618..626; 639..647; 653..655; 659..666; 667..669

Beta Strand

129..133; 136..139; 294..297; 318..323; 330..334; 347..350; 359..362; 383..385; 417..426; 429..436; 440..447; 475..479; 481..490; 532..536; 542..544; 550..552; 566..568; 587..590

3D Structure

NMR spectroscopy (2); X-ray crystallography (4)

Domain & Motif Annotations

Motif

596..603; CAV1-binding

Zinc Finger

113..149; Btk-type

Domain (CC)

SH2 domain mediates interaction with RUFY1..

Domain (FT)

4..111; PH; 296..392; SH2; 417..675; Protein kinase

Protein Families

Protein kinase superfamily
Tyr protein kinase family
TEC subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

Clinical Relevance

Drugs

CHLOROQUINE PF-06651600 PD-168393 CANERTINIB IBRUTINIB

Antibody

HPA001048 CAB032495

Interaction Protein

ENSG00000070778ENSG00000168610

Interaction Count

Interaction Dataset

intact_biogrid