Protein detail
JAK3
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Protein symbol JAK3 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK)
Protein Class
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- Cancer-related genes
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Synonym
JAK-3JAK3_HUMANJAKLL-JAKLJAK
Gene Description
Janus kinase 3
Chromosome
19
Position
17824780-17848071
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificfallopian tubeCell SpecificAstrocytesSingle-Nuclei Brain Specificependymal cellBlood Cell Specificbasophil
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- Cancer-related genes
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04062 Chemokine signaling pathway
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04217 Necroptosis
- KEGG:hsa04550 Signaling pathways regulating pluripotency of stem cells
- KEGG:hsa04630 JAK-STAT signaling pathway
- KEGG:hsa04658 Th1 and Th2 cell differentiation
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa05161 Hepatitis B
- KEGG:hsa05162 Measles
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
- KEGG:hsa05169 Epstein-Barr virus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05203 Viral carcinogenesis
- KEGG:hsa05223 Non-small cell lung cancer
- KEGG:hsa05340 Primary immunodeficiency
Reactome
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5663205 infectious disease
- R-hsa-8983432 interleukin 15 signaling
- R-hsa-8854691 interleukin 20 family signaling
- R-hsa-9020958 interleukin 21 signaling
- R-hsa-451927 interleukin 2 family signaling
- R-hsa-9020558 interleukin 2 signaling
- R-hsa-512988 interleukin 3 interleukin 5 and gm csf signaling
- R-hsa-6785807 interleukin 4 and interleukin 13 signaling
- R-hsa-1266695 interleukin 7 signaling
- R-hsa-8985947 interleukin 9 signaling
- R-hsa-912526 interleukin receptor shc signaling
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-9679506 sars cov infections
- R-hsa-201556 signaling by alk
- R-hsa-449147 signaling by interleukins
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9824446 viral infection pathways
Canonical Pathways
M232 Pid ecadherin stabilization pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| JAK3 | PTPN2 | P17706 | Y | 980 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:11909529 |
| JAK3 | PTPN2 | P17706 | Y | 981 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:11909529 |
| JAK3 | CDKL2 | Q92772 | Y | 506 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:10889465 |
| JAK3 | IGF1R | P08069 | Y | 981 | phosphorylation | KEA | KEA:17570479 |
| JAK3 | LCK | P06239 | Y | 981 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
30 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CXCR4 | P61073 | JAK3 | P52333 | Yes | Yes | No | WangHPRDSignaLink3InnateDBSPIKE_LCTCRcuration_SignaLink3 | SignaLink3:23109003SignaLink3:11406370SignaLink3:12495636HPRD:10506573InnateDB:10506573SignaLink3:17169327SPIKE_LC:16189514 |
| JAK3 | P52333 | CTNB1 | P35222 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_norefSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:33814980ProtMapper:28821617SIGNOR:28821617PhosphoSite:28821617 |
| I15RA | Q13261 | JAK3 | P52333 | Yes | Yes | No | WangSIGNOR | SIGNOR:30029643 |
| SOCS1 | O15524 | JAK3 | P52333 | Yes | No | Yes | NCI-PID_ProtMapperSIGNORProtMapperHPRDBioGRIDWang | ProtMapper:8458387ProtMapper:10950967ProtMapper:7822337ProtMapper:1948049ProtMapper:12459556ProtMapper:7973658HPRD:11133764ProtMapper:9799097SIGNOR:21508344ProtMapper:8624802ProtMapper:9380721ProtMapper:10201892BioGRID:27144517ProtMapper:8134361 |
| JAK3 | P52333 | SIG10 | Q96LC7 | Yes | Yes | No | WangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper | SIGNOR:11733002phosphoELM:11733002KEA:11733002ProtMapper:11733002 |
| JAK3 | P52333 | EZH2 | Q15910 | Yes | Yes | No | Sparser_ProtMapperSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:27297789PhosphoSite:32631994ProtMapper:33327550ProtMapper:29556394SIGNOR:28868240ProtMapper:28868240 |
| JAK3 | P52333 | PLD2 | O14939 | Yes | Yes | No | Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:20176813ProtMapper:21414324PhosphoSite:21414324ProtMapper:33368247PhosphoSite:23378025SIGNOR:20176813 |
| JAK3 | P52333 | NFAC1 | O95644 | Yes | Yes | No | iPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:23263556PhosphoSite:23263556PhosphoSite:24465763 |
| JAK3 | P52333 | SHC1 | P29353 | Yes | Yes | No | WangPhosphoSite_norefPhosphoSiteiPTMnet | PhosphoSite:24795043 |
| JAK3 | P52333 | ELAV1 | Q15717 | Yes | No | No | Sparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:24106086ProtMapper:24106086 |
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Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster67 | ALDH16A1DERAINSL3JAK1JAK2JAK3NAA20NAA25TYK2YJU2B | O60674P13994P23458P29597P51460P52333P61599Q14CX7Q8IZ83Q9Y315 | 1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC2854 | 22036573 |
| JAK3PTPN1 | P18031P52333 | 1:1 | PDB | PDB:8exm | ||
| JAK1JAK3 | P23458P52333 | 0:0 | KEGG-MEDICUS | |||
| JAK3 | P52333 | 4 | PDB | PDB:6aakPDB:6gl9PDB:4qpsPDB:6glaPDB:7apgPDB:5w86PDB:3zc6PDB:4v0gPDB:6glbPDB:4z16PDB:7uyvPDB:3zepPDB:7apfPDB:6hzv |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation๏ผDifferential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,124
Mass
125,099
Sequence
MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=2; Synonyms=JAK3S, Spleen-JAK3; IsoId=P52333-1; Sequence=Displayed; Name=1; Synonyms=JAK3B, Breast-JAK3; IsoId=P52333-2; Sequence=VSP_004989; Name=3; IsoId=P52333-4; Sequence=VSP_054165, VSP_054166
Alternative Sequence
597..619; TMVQEFVHLGAIDMYLRKRGHLV -> ESPPPTHPTPASPKSRLFFPPLF (in isoform 3); 620..1124; Missing (in isoform 3); 1071..1124; HELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS -> SAAGLASVSQSVDWAGVSGKPAGA (in isoform 1)
3D Structural Models
Turn
1022..1024
Helix
819..821; 862..877; 910..917; 918..920; 923..942; 952..954; 968..970; 991..993; 996..1001; 1006..1021; 1026..1028; 1030..1037; 1046..1055; 1068..1077; 1082..1084; 1088..1102
Beta Strand
816..818; 822..830; 832..841; 845..847; 849..859; 886..891; 893..896; 898..903; 955..959; 962..965; 979..982; 1003..1005; 1042..1044
3D Structure
X-ray crystallography (42)
Domain & Motif Annotations
Domain (CC)
Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1..
Domain (FT)
24..356; FERM; 375..475; SH2; atypical; 521..781; Protein kinase 1; 822..1111; Protein kinase 2
Region
1..223; Interaction with cytokine/interferon/growth hormone receptors
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- JAK subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targetsSCID
Drug Targets
FDA approved drug targets
Drugs
PACRITINIBQUIZARTINIBUPADACITINIBPHA-767491NEZULCITINIBPF-06651600GO-6976MIDOSTAURINWHI-P131CHEMBL:CHEMBL379975TOFACITINIBDECERNOTINIBGUSACITINIBSOTRASTAURINLAUROGUADINECERDULATINIBGILTERITINIBATEZOLIZUMABSELUMETINIBILGINATINIBR-333DELGOCITINIBPD-0166285PEFICITINIBSORAFENIBPF-562271NVP-TAE684RITLECITINIBADAVOSERTIBTASOCITINIBIZENCITINIBENTRECTINIBTAMATINIBTRICETAMIDERUXOLITINIBDEXAMETHASONEAT-9283R-348BARICITINIBRG-1530CENISERTIBCHEMBL:CHEMBL1997335CYC-116JNJ-7706621GW843682XAT9283
Antibody
Interaction Protein
ENSG00000102316ENSG00000187109
Interaction Count
2
Interaction Dataset
intact_biogrid