Protein detail
CTR2
Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)
Protein symbol CTR2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 14 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Cationic amino acid transporter 2 (CAT-2) (CAT2) (Low affinity cationic amino acid transporter 2) (Solute carrier family 7 member 2)
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
38..59; Helical; 64..84; Helical; 105..125; Helical; 164..184; Helical; 193..213; Helical; 249..269; Helical; 290..309; Helical; 340..360; Helical; 387..407; Helical; 411..431; Helical; 491..511; Helical; 525..549; Helical; 558..578; Helical; 583..603; Helical
Transmembrane Count
14
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificAstrocytesSingle-Nuclei Brain Specificleukocyte
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
- GO:0000064 L-ornithine transmembrane transporter activity
- GO:0015171 amino acid transmembrane transporter activity
- GO:0015174 basic amino acid transmembrane transporter activity
- GO:0015179 L-amino acid transmembrane transporter activity
- GO:0015189 L-lysine transmembrane transporter activity
- GO:0061459 L-arginine transmembrane transporter activity
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| slc7 | transporter | Surfaceome | No | Yes | No | No | No |
| apc | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30550287 |
Sequence, Structure & Domains
Sequences
Length
658
Mass
71,673
Sequence
MIPCRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTGLAEYPDFFAVCLILLLAGLLSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSENGTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTLFCPSLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVLFVAIVLTIWRQPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLIYFSYGIRHSLEGHLRDENNEEDAYPDNVHAAAEEKSAIQANDHHPRNLSSPFIFHEKTSEF
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CAT-2B, CAT2B, SLC7A2B; IsoId=P52569-1; Sequence=Displayed; Name=2; Synonyms=CAT-2A, CAT2A, SLC7A2A; IsoId=P52569-2; Sequence=VSP_037354, VSP_023354; Name=3; IsoId=P52569-3; Sequence=VSP_037354
Alternative Sequence
1; M -> MKIETSGYNSDKLICRGFIGTPAPPVCDSKFLLSPSSDVRM (in isoform 2 and isoform 3); 357..398; IFPMPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVA -> MFPLPRILFAMARDGLLFRFLARVSKRQSPVAATLTAGVIS (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Protein Families
- Amino acid-polyamine-organocation (APC) superfamily
- Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
Sequence Similarities
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.