Protein detail

EFNA5

Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)

Protein symbol EFNA5	UniProt ID P52803	EVMP score 0.25
Frequency 2	Transmembrane count	Protein classification Cancer-related genesPredicted membrane proteinsRAS pathway related proteins

Basic Information

Protein Names

Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)

Protein Class

Cancer-related genesPredicted membrane proteinsRAS pathway related proteins

Protein Function

Cancer-related genes:Candidate cancer biomarkers
RAS pathway related proteins

Ensembl

ENSG00000184349

Entrez Gene Symbol

EFNA5

Gene Synonym

AF1EPLG7LERK7

Gene Description

Ephrin A5

Chromosome

Position

107376894-107670937

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

Cancer-related genes:Candidate cancer biomarkers
RAS pathway related proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

51 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	HPMR	No	No	No	Yes	Yes
extracellular	extracellular	DGIdb	No	No	No	Yes	Yes
extracellular	extracellular	OmniPath	No	No	No	Yes	Yes
intracellular	intracellular	LOCATE	No	No	No	Yes	Yes
intracellular	intracellular	ComPPI	No	No	No	Yes	Yes
intracellular	intracellular	GO_Intercell	No	No	No	Yes	Yes
intracellular	intracellular	OmniPath	No	No	No	Yes	Yes
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	Yes	Yes
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	Yes
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	No	Yes	Yes

Page 1 of 6Next

Regulatory Interaction Network

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EFNA5	P52803	EPHA5	P54756	Yes	Yes	No	iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863 SignaLink3:18988627 connectomeDB2020:10531456 SignaLink3:10531456 HPMR:9330863 ICELLNET:24003208 SIGNOR:9330863 Cellinker:15114347 LRdb:11114742 CellChatDB:15114347 ICELLNET:15114347 Cellinker:10531456 SignaLink3:23331499 SignaLink3:9267020 HPRD:10531456 connectomeDB2020:9330863
EFNA5	P52803	EPHA6	Q9UF33	Yes	Yes	No	Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015connectomeDB2020SignaLink3CellinkerWangLRdbSTRING_talklrCellCallHPMR_talklr	Cellinker:9330863 CellTalkDB:11114742 LRdb:11114742 SignaLink3:9576626 SignaLink3:23331499 connectomeDB2020:9330863
EFNA5	P52803	EPHA7	Q15375	Yes	Yes	No	iTALKICELLNETCellPhoneDB_CellinkerSignaLink3CellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015CellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	SignaLink3:18988627 ICELLNET:24003208 Cellinker:15114347 Cellinker:10366629 HPRD:10366629 LRdb:11114742 SignaLink3:10366629 CellChatDB:15114347 ICELLNET:15114347 SignaLink3:9576626 SignaLink3:23331499 BioGRID:10366629 Baccin2019:10366629 connectomeDB2020:10366629
EFNA5	P52803	EPHA4	P54764	Yes	Yes	No	iTALKICELLNETSIGNORHINTCellPhoneDB_CellinkerSignaLink3DIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:15114347 HINT:19836338 IntAct:23812375 Baccin2019:9330863 connectomeDB2020:8755474 SignaLink3:8755474 SignaLink3:18988627 DIP:23812375 LRdb:11114742 CellChatDB:15114347 SignaLink3:23331499 HINT:23959867 connectomeDB2020:9330863 HINT:33961781 HINT:23812375 HPMR:9330863 ICELLNET:24003208 IntAct:19836338 HPRD:8755474 SIGNOR:9330863 DIP:19836338 ICELLNET:15114347 SignaLink3:9576626
EFNA5	P52803	EPHA3	P29320	Yes	Yes	No	iTALKICELLNETSIGNORHINTCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	HINT:9195962 Cellinker:9330863 HPRD:9751130 SignaLink3:9245480 HINT:19823572 Cellinker:15114347 connectomeDB2020:9751130 SignaLink3:9195962 SignaLink3:9751130 Cellinker:9751130 HINT:9245480 Cellinker:9195962 SignaLink3:18988627 connectomeDB2020:9195962 HPRD:9195962 LRdb:11114742 Cellinker:9245480 BioGRID:22242939 CellChatDB:15114347 HINT:25993310 HPRD:9245480 SignaLink3:23331499 HINT:22242939 connectomeDB2020:9245480 connectomeDB2020:9330863 HINT:33961781 SignaLink3:21071413 HPMR:9330863 ICELLNET:24003208 SIGNOR:9330863 ICELLNET:15114347 SignaLink3:9576626 BioGRID:9245480
EFNA5	P52803	EPHA8	P29322	Yes	Yes	No	iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863Baccin2019:933086311416136HPMR:9330863 connectomeDB2020:11416136 ICELLNET:24003208 Cellinker:11416136 Cellinker:15114347 SIGNOR:9330863 SignaLink3:11416136 LRdb:11114742 CellChatDB:15114347 HPRD:11416136 ICELLNET:15114347 SignaLink3:23331499 SignaLink3:9576626 connectomeDB2020:9330863
EFNA5	P52803	EPHA2	P29317	Yes	Yes	No	iTALKICELLNETSIGNORProtMapperHINTCellPhoneDB_CellinkerDIPHPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerREACH_ProtMapperSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863 DIP:20505120 IntAct:20228801 Cellinker:15114347 ProtMapper:22570727 Baccin2019:9330863 IntAct:20505120 HINT:20228801 HINT:20505120 LRdb:11114742 Cellinker:9245480 HPRD:9245480 CellChatDB:15114347 connectomeDB2020:9245480 connectomeDB2020:9330863 HINT:33961781 ICELLNET:24003208 SIGNOR:9330863 ICELLNET:15114347 DIP:20228801

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	EFNA5 EPHA8	P29322 P52803	0:0	hu.MAP2

Isolation & Detection Technology

0 records.

Sequence, Structure & Domains

Sequences

Length

228

Mass

26,297

Sequence

MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL

3D Structural Models

Turn

93..95

Helix

41..43; 71..73; 84..89; 161..164

Beta Strand

31..35; 44..46; 49..52; 57..61; 76..82; 96..102; 108..111; 113..117; 135..144; 153..158

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

190..200; Basic and acidic residues

Domain (FT)

29..162; Ephrin RBD

Region

186..205; Disordered

Protein Families

Ephrin family

Sequence Similarities

Belongs to the ephrin family.

Clinical Relevance

Disease Involvement

Cancer-related genes

Drugs

CCT244747

Antibody

CAB013282 HPA054047

Interaction Protein

ENSG00000116106ENSG00000135333ENSG00000140519

Interaction Count

Interaction Dataset

intact_biogrid