Protein detail
EFNA5
Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)
Entry name EFNA5 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Cancer-related genesPredicted membrane proteinsRAS pathway related proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)
Protein Class (3)
Cancer-related genesPredicted membrane proteinsRAS pathway related proteins
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- RAS pathway related proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
AF1EPLG7LERK7
Gene Description
Ephrin A5
Chromosome
5
Position
107376894-107670937
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization3
Cell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway7
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- RAS pathway related proteins
Cellular Component (6)
Molecular Function (7)
- GO:0005168 neurotrophin TRKA receptor binding
- GO:0005169 neurotrophin TRKB receptor binding
- GO:0005170 neurotrophin TRKC receptor binding
- GO:0005515 protein binding
- GO:0030297 transmembrane receptor protein tyrosine kinase activator activity
- GO:0045499 chemorepellent activity
- GO:0046875 ephrin receptor binding
Biological Process (3)
KEGG (6)
Reactome (4)
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence59
Ligand-Receptor Signaling (51)
51 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | Yes |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | Yes |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | Yes |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | Yes |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | Yes |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | Yes |
| plasma_membrane_peripheral | plasma_membrane_peripheral | CSPA | No | No | No | Yes | Yes |
Regulatory Interaction Network (7)
7 records.
Sequence, Structure & Domains12
Sequences
Length
228
Mass
26,297
Sequence
MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
3D Structural Models
Turn
93..95
Helix
41..43; 71..73; 84..89; 161..164
Beta Strand
31..35; 44..46; 49..52; 57..61; 76..82; 96..102; 108..111; 113..117; 135..144; 153..158
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
190..200; Basic and acidic residues
Domain (FT)
29..162; Ephrin RBD
Region
186..205; Disordered
Protein Families
Ephrin family
Sequence Similarities
Belongs to the ephrin family.
Clinical Relevance6
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 25755179 | Urinary extracellular vesicles as reservoirs of altered proteins during the pathogenesis of polycystic kidney disease. | No abstract available |
| 30915084 | Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton. | No abstract available |