Protein detail

EFNA5

Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)

Protein symbol EFNA5	UniProt ID P52803	EVMP score 0.25
Frequency 2	Transmembrane count	Protein classification Cancer-related genesPredicted membrane proteinsRAS pathway related proteins

Basic Information

Protein Names

Ephrin-A5 (AL-1) (EPH-related receptor tyrosine kinase ligand 7) (LERK-7)

Protein Class

Cancer-related genesPredicted membrane proteinsRAS pathway related proteins

Protein Function

Cancer-related genes:Candidate cancer biomarkers
RAS pathway related proteins

Ensembl

ENSG00000184349

Entrez Gene Symbol

EFNA5

Gene Synonym

AF1EPLG7LERK7

Gene Description

Ephrin A5

Chromosome

Position

107376894-107670937

Frequency

EVMP Score

0.25

Fluorescence & Localization

Cell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway

Protein Function

Cancer-related genes:Candidate cancer biomarkers
RAS pathway related proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

51 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	Yes

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Regulatory Interaction Network

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EFNA5	P52803	EPHA5	P54756	Yes	Yes	No	iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863 SignaLink3:18988627 connectomeDB2020:10531456 SignaLink3:10531456 HPMR:9330863 ICELLNET:24003208 SIGNOR:9330863 Cellinker:15114347 LRdb:11114742 CellChatDB:15114347 ICELLNET:15114347 Cellinker:10531456 SignaLink3:23331499 SignaLink3:9267020 HPRD:10531456 connectomeDB2020:9330863
EFNA5	P52803	EPHA6	Q9UF33	Yes	Yes	No	Fantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015connectomeDB2020SignaLink3CellinkerWangLRdbSTRING_talklrCellCallHPMR_talklr	Cellinker:9330863 CellTalkDB:11114742 LRdb:11114742 SignaLink3:9576626 SignaLink3:23331499 connectomeDB2020:9330863
EFNA5	P52803	EPHA7	Q15375	Yes	Yes	No	iTALKICELLNETCellPhoneDB_CellinkerSignaLink3CellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015CellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbconnectomeDB2020LRdb	SignaLink3:18988627 ICELLNET:24003208 Cellinker:15114347 Cellinker:10366629 HPRD:10366629 LRdb:11114742 SignaLink3:10366629 CellChatDB:15114347 ICELLNET:15114347 SignaLink3:9576626 SignaLink3:23331499 BioGRID:10366629 Baccin2019:10366629 connectomeDB2020:10366629
EFNA5	P52803	EPHA4	P54764	Yes	Yes	No	iTALKICELLNETSIGNORHINTCellPhoneDB_CellinkerSignaLink3DIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:15114347 HINT:19836338 IntAct:23812375 Baccin2019:9330863 connectomeDB2020:8755474 SignaLink3:8755474 SignaLink3:18988627 DIP:23812375 LRdb:11114742 CellChatDB:15114347 SignaLink3:23331499 HINT:23959867 connectomeDB2020:9330863 HINT:33961781 HINT:23812375 HPMR:9330863 ICELLNET:24003208 IntAct:19836338 HPRD:8755474 SIGNOR:9330863 DIP:19836338 ICELLNET:15114347 SignaLink3:9576626
EFNA5	P52803	EPHA3	P29320	Yes	Yes	No	iTALKICELLNETSIGNORHINTCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	HINT:9195962 Cellinker:9330863 HPRD:9751130 SignaLink3:9245480 HINT:19823572 Cellinker:15114347 connectomeDB2020:9751130 SignaLink3:9195962 SignaLink3:9751130 Cellinker:9751130 HINT:9245480 Cellinker:9195962 SignaLink3:18988627 connectomeDB2020:9195962 HPRD:9195962 LRdb:11114742 Cellinker:9245480 BioGRID:22242939 CellChatDB:15114347 HINT:25993310 HPRD:9245480 SignaLink3:23331499 HINT:22242939 connectomeDB2020:9245480 connectomeDB2020:9330863 HINT:33961781 SignaLink3:21071413 HPMR:9330863 ICELLNET:24003208 SIGNOR:9330863 ICELLNET:15114347 SignaLink3:9576626 BioGRID:9245480
EFNA5	P52803	EPHA8	P29322	Yes	Yes	No	iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863Baccin2019:933086311416136HPMR:9330863 connectomeDB2020:11416136 ICELLNET:24003208 Cellinker:11416136 Cellinker:15114347 SIGNOR:9330863 SignaLink3:11416136 LRdb:11114742 CellChatDB:15114347 HPRD:11416136 ICELLNET:15114347 SignaLink3:23331499 SignaLink3:9576626 connectomeDB2020:9330863
EFNA5	P52803	EPHA2	P29317	Yes	Yes	No	iTALKICELLNETSIGNORProtMapperHINTCellPhoneDB_CellinkerDIPHPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerREACH_ProtMapperSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863 DIP:20505120 IntAct:20228801 Cellinker:15114347 ProtMapper:22570727 Baccin2019:9330863 IntAct:20505120 HINT:20228801 HINT:20505120 LRdb:11114742 Cellinker:9245480 HPRD:9245480 CellChatDB:15114347 connectomeDB2020:9245480 connectomeDB2020:9330863 HINT:33961781 ICELLNET:24003208 SIGNOR:9330863 ICELLNET:15114347 DIP:20228801

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	EFNA5 EPHA8	P29322 P52803	0:0	hu.MAP2

Isolation & Detection Technology

0 records.

Sequence, Structure & Domains

Sequences

Length

228

Mass

26,297

Sequence

MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL

3D Structural Models

Turn

93..95

Helix

41..43; 71..73; 84..89; 161..164

Beta Strand

31..35; 44..46; 49..52; 57..61; 76..82; 96..102; 108..111; 113..117; 135..144; 153..158

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

190..200; Basic and acidic residues

Domain (FT)

29..162; Ephrin RBD

Region

186..205; Disordered

Protein Families

Ephrin family

Sequence Similarities

Belongs to the ephrin family.

Clinical Relevance

Disease Involvement

Cancer-related genes

Drugs

CCT244747

Antibody

CAB013282 HPA054047

Interaction Protein

ENSG00000116106ENSG00000135333ENSG00000140519

Interaction Count

Interaction Dataset

intact_biogrid