Protein detail
SC5A3
Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3)
Entry name SC5A3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 12 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Sodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3)
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
10..29; Helical; 39..57; Helical; 87..110; Helical; 124..144; Helical; 158..183; Helical; 187..205; Helical; 304..324; Helical; 354..376; Helical; 407..430; Helical; 444..462; Helical; 511..532; Helical; 696..716; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization2
Cell SpecificDistal convoluted tubule cellsBlood Cell SpecificgdT-cell
Function & Pathway7
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component (6)
Molecular Function (9)
- GO:0005365 myo-inositol transmembrane transporter activity
- GO:0005367 myo-inositol:sodium symporter activity
- GO:0005412 D-glucose:sodium symporter activity
- GO:0005515 protein binding
- GO:0015146 pentose transmembrane transporter activity
- GO:0015150 fucose transmembrane transporter activity
- GO:0015166 polyol transmembrane transporter activity
- GO:0015459 potassium channel regulator activity
- GO:0044325 transmembrane transporter binding
Biological Process (3)
Reactome (2)
Canonical Pathways (3)
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
- M5889 Naba matrisome
Mediation Categories (3)
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence27
Ligand-Receptor Signaling (26)
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| slc5 | transporter | Surfaceome | No | Yes | No | No | No |
| apc | transporter | Surfaceome | No | Yes | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 31753726 |
Sequence, Structure & Domains5
Sequences
Length
718
Mass
79,664
Sequence
MRAVLDTADIAIVALYFILVMCIGFFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQVYFAALSLILYIFTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLMIISIMEIGGFEEVKRRYMLASPDVTSILLTYNLSNTNSCNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFTDDIACINPEHCMLVCGSRAGCSNIAYPRLVMKLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVVISIAWVPIIVEMQGGQMYLYIQEVADYLTPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFAYRAPECDQPDNRPGFIKDIHYMYVATGLFWVTGLITVIVSLLTPPPTKEQIRTTTFWSKKNLVVKENCSPKEEPYKMQEKSILRCSENNETINHIIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALMGEKERKKETDDGGRYWKFIDWFCGFKSKSLSKRSLRDLMEEEAVCLQMLEETRQVKVILNIGLFAVCSLGIFMFVYFSL
Domain & Motif Annotations
Protein Families
Sodium:solute symporter (SSF) (TC 2.A.21) family
Sequence Similarities
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 28396511 | Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. | No abstract available |