Protein detail
UBP14
Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)
Protein symbol UBP14 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)
Protein Class
EnzymesMetabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
- Peptidases:Cysteine-type peptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
TGTUbp6
Gene Description
Ubiquitin specific peptidase 14
Chromosome
18
Position
158383-214629
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificchoroid plexusCell SpecificEarly spermatids
Function & Pathway
Protein Function
- Peptidases:Cysteine-type peptidases
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5688426 deubiquitination
- R-hsa-168249 innate immune system
- R-hsa-446652 interleukin 1 family signaling
- R-hsa-9020702 interleukin 1 signaling
- R-hsa-166166 myd88 independent tlr4 cascade
- R-hsa-597592 post translational protein modification
- R-hsa-9758274 regulation of nf kappa b signaling
- R-hsa-449147 signaling by interleukins
- R-hsa-445989 tak1 dependent ikk and nf kappa b activation
- R-hsa-168138 toll like receptor 9 tlr9 cascade
- R-hsa-168898 toll like receptor cascades
- R-hsa-168179 toll like receptor tlr1 tlr2 cascade
- R-hsa-5689880 ub specific processing proteases
Mediation Categories
Clinical-translation mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
2 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| USP14 | AKT1 | P31749 | S | 432 | phosphorylation | SIGNORPhosphoSitePhosphoSite_ProtMapperProtMapper | SIGNOR:26523394 |
| USP14 | CDK1 | P06493 | T | 235 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| UBP14 | P54578 | CXCR4 | P61073 | Yes | Yes | No | WangSIGNOR | SIGNOR:26523394 |
| AKT1 | P31749 | UBP14 | P54578 | Yes | Yes | No | PhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:26523394SIGNOR:26523394 |
| CDK1 | P06493 | UBP14 | P54578 | Yes | No | No | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:26523394 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
494
Mass
56,069
Sequence
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P54578-1; Sequence=Displayed; Name=2; IsoId=P54578-2; Sequence=VSP_047343; Name=3; IsoId=P54578-3; Sequence=VSP_057292
Alternative Sequence
55..65; Missing (in isoform 3); 66..100; Missing (in isoform 2)
3D Structural Models
Turn
303..306; 335..338; 409..412
Helix
114..124; 127..135; 147..165; 173..182; 184..187; 200..214; 242..247; 286..293; 356..358; 361..376; 460..464; 465..467
Beta Strand
110..112; 142..144; 167..170; 191..193; 249..259; 261..263; 266..273; 275..278; 280..282; 295..302; 307..319; 321..329; 331..334; 339..342; 351..354; 404..406; 414..429; 435..443; 446..451; 454..458; 469..472; 474..482
3D Structure
Electron microscopy (14); X-ray crystallography (9)
Domain & Motif Annotations
Domain (FT)
4..80; Ubiquitin-like; 105..483; USP
Protein Families
- Peptidase C19 family
- USP14/UBP6 subfamily
Sequence Similarities
Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
Clinical Relevance
Related Diseases
Biomarker
Preclinical
Drugs
Antibody
Interaction Protein
ENSG00000013275ENSG00000108344ENSG00000108671ENSG00000127922ENSG00000161057ENSG00000163636ENSG00000175166ENSG00000197170
Interaction Count
8
Interaction Dataset
biogrid_opencell