Protein detail
AT1B3
Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298)
Entry name AT1B3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification CD markersMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298)
Protein Class (5)
CD markersMetabolic proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (3)
- Transporters:Primary Active Transporters
- CD markers
- Predicted intracellular proteins
Transmembrane
36..56; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
CD298FLJ29027
Gene Description
ATPase Na+/K+ transporting subunit beta 3
Chromosome
3
Position
141876124-141926549
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue Specificblood vesselCell SpecificAdipocytesSingle-Nuclei Brain Specificoligodendrocyte precursor cell
Function & Pathway7
Protein Function (3)
- Transporters:Primary Active Transporters
- CD markers
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function (4)
Biological Process (3)
KEGG (19)
- hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04260 Cardiac muscle contraction
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa04911 Insulin secretion
- KEGG:hsa04918 Thyroid hormone synthesis
- KEGG:hsa04919 Thyroid hormone signaling pathway
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04960 Aldosterone-regulated sodium reabsorption
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Reactome (13)
- R-hsa-210991 basigin interactions
- R-hsa-5576891 cardiac conduction
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-109582 hemostasis
- R-hsa-5663205 infectious disease
- R-hsa-983712 ion channel transport
- R-hsa-5578775 ion homeostasis
- R-hsa-936837 ion transport by p type atpases
- R-hsa-397014 muscle contraction
- R-hsa-9679191 potential therapeutics for sars
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Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence34
Ligand-Receptor Signaling (30)
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transporter | transporter | Surfaceome | No | Yes | No | Yes | No |
| sodium_potassium_atpase | transporter | HGNC | No | Yes | No | Yes | No |
| transporter | transporter | HGNC | No | Yes | No | Yes | No |
| auxiliary_transport_unit | transporter | Almen2009 | No | Yes | No | Yes | No |
| atp1b | transporter | Surfaceome | No | Yes | No | Yes | No |
| auxillarytransportunit | transporter | Surfaceome | No | Yes | No | Yes | No |
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Protein Complex Composition (3)
Isolation & Detection Technology (1)
1 record.
Sequence, Structure & Domains9
Sequences
Length
279
Mass
31,513
Sequence
MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWVMLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLEEQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIGLKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P54709-1; Sequence=Displayed; Name=2; IsoId=P54709-2; Sequence=VSP_056686, VSP_056687
Alternative Sequence
1..36; MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSW -> MLSEGDILFSSLLSSPSLFWPP (in isoform 2); 195..279; NEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA -> TNNVKDGMKIYQM (in isoform 2)
Domain & Motif Annotations
Domain (CC)
The C-terminal lobe folds into an immunoglobulin-like domain and may mediate cell adhesion properties.
Region
186..279; immunoglobulin-like
Protein Families
X(+)/potassium ATPases subunit beta family
Sequence Similarities
Belongs to the X(+)/potassium ATPases subunit beta family.
Clinical Relevance5
Interaction Protein (3)
ENSG00000105409ENSG00000127022ENSG00000163399
Interaction Count
3
Interaction Dataset (3)
biogrid_bioplexbiogrid_opencell_bioplexbiogrid_opencell
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 36146834 | Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |