Protein detail
EPHB3
Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6)
Entry name EPHB3 | UniProt ID | EVMP score 0.38 |
Frequency 6 | Transmembrane count 1 | Protein classification Cancer-related genesEnzymesPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6)
Protein Class
Cancer-related genesEnzymesPredicted membrane proteins
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
Transmembrane
560..580; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ETK2Hek2Tyro6
Gene Description
EPH receptor B3
Chromosome
3
Position
184561785-184582408
Frequency
6
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificskin 1Cell SpecificBasal keratinocytesSingle-Nuclei Brain Specificdeep-layer corticothalamic and 6b
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Kinases:Tyr protein kinases
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| EPHB3 | EPHA1 | P21709 | Y | 614 | phosphorylation | Li2012 | |
| EPHB3 | ZAP70 | P43403 | Y | 614 | phosphorylation | PhosphoNetworks | |
| EPHB3 | HCK | P08631 | Y | 614 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
67 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| EFNB3 | Q15768 | EPHB3 | P54753 | Yes | Yes | No | iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:9330863SignaLink3:18988627connectomeDB2020:9330863ICELLNET:24003208Cellinker:9484836SIGNOR:9330863Cellinker:15114347connectomeDB2020:9484836LRdb:11114742CellChatDB:15114347ICELLNET:15114347HPRD:9484836SignaLink3:23331499SignaLink3:9267020Baccin2019:93308639484836SIGNOR:9484836SignaLink3:21071413SignaLink3:9484836 |
| EFNB1 | P98172 | EPHB3 | P54753 | Yes | Yes | No | iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBDLRP_CellinkertalklrRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:9330863connectomeDB2020:9330863HPMR:9330863ICELLNET:24003208SIGNOR:9330863Cellinker:15114347LRdb:11114742CellChatDB:15114347ICELLNET:15114347SignaLink3:9576626SignaLink3:23331499Baccin2019:9330863 |
| EFNB2 | P52799 | EPHB3 | P54753 | Yes | Yes | No | iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBDLRP_CellinkertalklrRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:9330863CellTalkDB:15114347connectomeDB2020:9330863ICELLNET:24003208SIGNOR:9330863Cellinker:15114347SIGNOR:8559144LRdb:11114742CellChatDB:15114347ICELLNET:15114347SignaLink3:9576626SignaLink3:23331499Baccin2019:9330863 |
| EPHB3 | P54753 | RASA1 | P20936 | Yes | Yes | No | PhosphoPointHPRDSignaLink3Li2012Wang | HPRD:9674711SignaLink3:9674711SignaLink3:23331499 |
| EPHB3 | P54753 | AFAD | P55196 | Yes | Yes | No | DOMINOPhosphoPointHPRDSignaLink3SPIKE_LCLit-BM-17 | SPIKE_LC:9707552DOMINO:9707552SignaLink3:9707552SignaLink3:23331499Lit-BM-17:9707552HPRD:9707552 |
| EPHB3 | P54753 | CDN1B | P46527 | Yes | No | Yes | REACH_ProtMapperSIGNORSparser_ProtMapperProtMapper | ProtMapper:10389236SIGNOR:10389236 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation๏ผDifferential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
998
Mass
110,330
Sequence
MARARPPPPPSPPPGLLPLLPPLLLLPLLLLPAGCRALEETLMDTKWVTSELAWTSHPESGWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLRTGFIWRRDVQRVYVELKFTVRDCNSIPNIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTIAPDESFSRLDAGRVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPETLTGAEPTSLVIAPGTCIPNAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRPCPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGVISNVNETSLILEWSEPRDLGGRDDLLYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLTERRVHISHLLAHTRYTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLRLHSSSGSSLTLSWAPPERPNGVILDYEMKYFEKSEGIASTVTSQMNSVQLDGLRPDARYVVQVRARTVAGYGQYSRPAEFETTSERGSGAQQLQEQLPLIVGSATAGLVFVVAVVVIAIVCLRKQRHGSDSEYTEKLQQYIAPGMKVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVIASAQSGMSQPLLDRTVPDYTTFTTVGDWLDAIKMGRYKESFVSAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILSSIQDMRLQMNQTLPVQV
3D Structural Models
Turn
726..728; 838..841; 879..881
Helix
45..47; 116..118; 673..687; 719..725; 732..751; 761..763; 802..804; 807..812; 817..832; 844..852; 865..874; 885..897; 899..902
Beta Strand
39..44; 55..58; 63..68; 74..80; 85..87; 90..93; 103..114; 130..139; 155..160; 175..181; 186..198; 200..210; 633..640; 646..652; 655..657; 660..666; 697..701; 703..706; 708..712; 764..766; 772..774; 791..793; 796..798
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Motif
996..998; PDZ-binding
Domain (FT)
39..217; Eph LBD; 339..451; Fibronectin type-III 1; 452..545; Fibronectin type-III 2; 633..896; Protein kinase; 925..989; SAM
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- Ephrin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genes
Drugs
ILGINATINIBFILGOTINIB-SARย 20347.00RITLECITINIBRUXOLITINIBXL019PF-06263276GANDOTINIBJAK INHIBITOR 17BJAK INHIBITOR 20ASOLCITINIBLASW1393CEP-33779COMPOUND 1D [PMID: 21493067]SJ988497DELGOCITINIBCERDULATINIBLAZERTINIBCOMPOUND 8L [PMID: 36053746]ACALABRUTINIBMIVAVOTINIBMOMELOTINIBFEDRATINIBCEE321IZENCITINIBJAK3 INHIBITOR 34UPADACITINIBPACRITINIBDECERNOTINIBPEFICITINIBPF-956980GDC-0214COMPOUND 19A [PMID: 24359159]COMPOUND 25AP [PMID: 37796543]AZD1480PRN694COMPOUND 30 [PMID: 37057760]BARICITINIBABIVERTINIBCOMPOUND 2 [PMID: 15546730]COMPOUND 18E [PMID: 31670517]NEZULCITINIBPOSELTINIBOCLACITINIBBMS-911543BREPOCITINIBJAK3 INHIBITOR 32VANDETANIBCOMPOUND 13AC [PMID: 33256400]LORPUCITINIBJAK3 INHIBITOR IIIBRUTINIBAT-9283LEPZACITINIBJAK3 INHIBITOR IVTOFACITINIBNIK INHIBITOR 12F2-TERT-BUTYL-9-FLUORO-1,6-DIHYDROBENZO[H]IMIDAZO[4,5-F]ISOQUINOLIN-7-ONE