Protein detail
EPHA5
Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
Protein symbol EPHA5 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Kinases:Tyr protein kinases
Transmembrane
574..594; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificKupffer cells
Function & Pathway
Protein Function
- ENZYME proteins:Transferases
- Enzymes
- Kinases:Tyr protein kinases
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M18 Pid integrin1 pathway
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
Mediation Categories
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
56 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | SignaLink_function | No | Yes | No | Yes | No |
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Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| EFNA5 | P52803 | EPHA5 | P54756 | Yes | Yes | No | iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:9330863SignaLink3:18988627connectomeDB2020:10531456SignaLink3:10531456HPMR:9330863ICELLNET:24003208SIGNOR:9330863Cellinker:15114347LRdb:11114742CellChatDB:15114347ICELLNET:15114347Cellinker:10531456SignaLink3:23331499SignaLink3:9267020HPRD:10531456connectomeDB2020:9330863 |
| EFNA1 | P20827 | EPHA5 | P54756 | Yes | Yes | No | iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:9330863connectomeDB2020:8755474ICELLNET:24003208HPRD:8755474Cellinker:15114347LRdb:11114742CellChatDB:15114347ICELLNET:15114347Cellinker:8755474SignaLink3:23331499SignaLink3:9576626SIGNOR:9576626connectomeDB2020:9330863 |
| EFNA2 | O43921 | EPHA5 | P54756 | Yes | Yes | No | iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:9330863connectomeDB2020:10531456SignaLink3:10531456ICELLNET:24003208Cellinker:15114347LRdb:11114742CellChatDB:15114347ICELLNET:15114347SIGNOR:10072375Cellinker:10531456SignaLink3:23331499SignaLink3:9576626HPRD:10531456connectomeDB2020:9330863 |
| EFNA3 | P52797 | EPHA5 | P54756 | Yes | Yes | No | iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:9330863ICELLNET:24003208SIGNOR:9330863Cellinker:15114347Cellinker:10516308LRdb:11114742CellChatDB:15114347HPRD:10516308ICELLNET:15114347SignaLink3:23331499SignaLink3:9576626connectomeDB2020:9330863connectomeDB2020:10516308SignaLink3:10516308 |
| EFNA4 | P52798 | EPHA5 | P54756 | Yes | Yes | No | iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | Cellinker:9330863connectomeDB2020:8755474ICELLNET:24003208HPRD:8755474Cellinker:15114347HPRD:10607706SIGNOR:9330863LRdb:11114742CellChatDB:15114347Cellinker:10607706Cellinker:8755474ICELLNET:15114347SignaLink3:23331499SignaLink3:9576626connectomeDB2020:10607706connectomeDB2020:9330863 |
| EPHA5 | P54756 | LGUL | Q04760 | Yes | Yes | No | SIGNOR | SIGNOR:34838714 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 29573061 |
Sequence, Structure & Domains
Sequences
Length
1,037
Mass
114,803
Sequence
MRGSGPRGAGRRRPPSGGGDTPITPASLAGCYSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCECGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLAEHSPLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P54756-1; Sequence=Displayed; Name=2; IsoId=P54756-2; Sequence=VSP_002999; Name=3; IsoId=P54756-3; Sequence=VSP_039118, VSP_039119
Alternative Sequence
1..69; Missing (in isoform 3); 563; F -> SV (in isoform 3); 597..619; SCCECGCGRASSLCAVAHPSLIW -> R (in isoform 2)
3D Structural Models
Turn
66..68; 767..770; 878..881
Helix
137..139; 166..168; 663..665; 672..674; 715..728; 761..766; 774..793; 803..805; 842..844; 847..852; 857..873; 884..893; 905..914; 919..921; 925..936
Beta Strand
61..65; 76..89; 95..101; 105..107; 111..114; 126..135; 148..157; 172..178; 188..192; 196..202; 207..219; 221..230; 675..683; 685..694; 702..708; 739..743; 745..748; 750..754; 806..808; 814..816
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Motif
1035..1037; PDZ-binding
Domain (FT)
60..238; Eph LBD; 357..467; Fibronectin type-III 1; 468..562; Fibronectin type-III 2; 675..936; Protein kinase; 965..1029; SAM
Region
1..24; Disordered
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- Ephrin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Clinical Relevance
Interaction Protein
ENSG00000142627
Interaction Count
1
Interaction Dataset
intact_biogrid