Protein detail

EPHA5

Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)

Protein symbol EPHA5	UniProt ID P54756	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Ephrin type-A receptor 5 (EC 2.7.10.1) (Brain-specific kinase) (EPH homology kinase 1) (EHK-1) (EPH-like kinase 7) (EK7) (hEK7)

Protein Function

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases

Transmembrane

574..594; Helical

Transmembrane Count

Ensembl

ENSG00000145242

Entrez Gene Symbol

EPHA5

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificKupffer cells

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04360 Axon guidance

Reactome

Canonical Pathways

M18 Pid integrin1 pathway
M5880 Naba ecm affiliated
M5885 Naba matrisome associated

Mediation Categories

Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

56 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No

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Regulatory Interaction Network

6 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EFNA5	P52803	EPHA5	P54756	Yes	Yes	No	iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863 SignaLink3:18988627 connectomeDB2020:10531456 SignaLink3:10531456 HPMR:9330863 ICELLNET:24003208 SIGNOR:9330863 Cellinker:15114347 LRdb:11114742 CellChatDB:15114347 ICELLNET:15114347 Cellinker:10531456 SignaLink3:23331499 SignaLink3:9267020 HPRD:10531456 connectomeDB2020:9330863
EFNA1	P20827	EPHA5	P54756	Yes	Yes	No	iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863 connectomeDB2020:8755474 ICELLNET:24003208 HPRD:8755474 Cellinker:15114347 LRdb:11114742 CellChatDB:15114347 ICELLNET:15114347 Cellinker:8755474 SignaLink3:23331499 SignaLink3:9576626 SIGNOR:9576626 connectomeDB2020:9330863
EFNA2	O43921	EPHA5	P54756	Yes	Yes	No	iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863 connectomeDB2020:10531456 SignaLink3:10531456 ICELLNET:24003208 Cellinker:15114347 LRdb:11114742 CellChatDB:15114347 ICELLNET:15114347 SIGNOR:10072375 Cellinker:10531456 SignaLink3:23331499 SignaLink3:9576626 HPRD:10531456 connectomeDB2020:9330863
EFNA3	P52797	EPHA5	P54756	Yes	Yes	No	iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863 ICELLNET:24003208 SIGNOR:9330863 Cellinker:15114347 Cellinker:10516308 LRdb:11114742 CellChatDB:15114347 HPRD:10516308 ICELLNET:15114347 SignaLink3:23331499 SignaLink3:9576626 connectomeDB2020:9330863 connectomeDB2020:10516308 SignaLink3:10516308
EFNA4	P52798	EPHA5	P54756	Yes	Yes	No	iTALKICELLNETSIGNORCellPhoneDB_CellinkerSignaLink3HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDDLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrCellinkerCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:9330863 connectomeDB2020:8755474 ICELLNET:24003208 HPRD:8755474 Cellinker:15114347 HPRD:10607706 SIGNOR:9330863 LRdb:11114742 CellChatDB:15114347 Cellinker:10607706 Cellinker:8755474 ICELLNET:15114347 SignaLink3:23331499 SignaLink3:9576626 connectomeDB2020:10607706 connectomeDB2020:9330863
EPHA5	P54756	LGUL	Q04760	Yes	Yes	No	SIGNOR	SIGNOR:34838714

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	29573061

Sequence, Structure & Domains

Sequences

Length

1,037

Mass

114,803

Sequence

MRGSGPRGAGRRRPPSGGGDTPITPASLAGCYSAPRRAPLWTCLLLCAALRTLLASPSNEVNLLDSRTVMGDLGWIAFPKNGWEEIGEVDENYAPIHTYQVCKVMEQNQNNWLLTSWISNEGASRIFIELKFTLRDCNSLPGGLGTCKETFNMYYFESDDQNGRNIKENQYIKIDTIAADESFTELDLGDRVMKLNTEVRDVGPLSKKGFYLAFQDVGACIALVSVRVYYKKCPSVVRHLAVFPDTITGADSSQLLEVSGSCVNHSVTDEPPKMHCSAEGEWLVPIGKCMCKAGYEEKNGTCQVCRPGFFKASPHIQSCGKCPPHSYTHEEASTSCVCEKDYFRRESDPPTMACTRPPSAPRNAISNVNETSVFLEWIPPADTGGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSGLKNTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISLSWQEPDRPNGIILEYEIKYFEKDQETSYTIIKSKETTITAEGLKPASVYVFQIRARTAAGYGVFSRRFEFETTPVFAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCECGCGRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNPSSLKTLVNASCRVSNLLAEHSPLGSGAYRSVGEWLEAIKMGRYTEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMNSLQEMKVQLVNGMVPL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P54756-1; Sequence=Displayed; Name=2; IsoId=P54756-2; Sequence=VSP_002999; Name=3; IsoId=P54756-3; Sequence=VSP_039118, VSP_039119

Alternative Sequence

1..69; Missing (in isoform 3); 563; F -> SV (in isoform 3); 597..619; SCCECGCGRASSLCAVAHPSLIW -> R (in isoform 2)

3D Structural Models

Turn

66..68; 767..770; 878..881

Helix

137..139; 166..168; 663..665; 672..674; 715..728; 761..766; 774..793; 803..805; 842..844; 847..852; 857..873; 884..893; 905..914; 919..921; 925..936

Beta Strand

61..65; 76..89; 95..101; 105..107; 111..114; 126..135; 148..157; 172..178; 188..192; 196..202; 207..219; 221..230; 675..683; 685..694; 702..708; 739..743; 745..748; 750..754; 806..808; 814..816

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Motif

1035..1037; PDZ-binding

Domain (FT)

60..238; Eph LBD; 357..467; Fibronectin type-III 1; 468..562; Fibronectin type-III 2; 675..936; Protein kinase; 965..1029; SAM

Region

1..24; Disordered

Protein Families

Protein kinase superfamily
Tyr protein kinase family
Ephrin receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

Clinical Relevance

Drugs

IRAK3 PROTAC 23 PACLITAXEL COMPOUND R-16 [PMID: 21967808]HESPERADIN VANDETANIB

Interaction Protein

ENSG00000142627

Interaction Count

Interaction Dataset

intact_biogrid