Protein detail
RAD
GTP-binding protein RAD (RAD1) (Ras associated with diabetes)
Entry name RAD | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
GTP-binding protein RAD (RAD1) (Ras associated with diabetes)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
RADREM3
Gene Description
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Chromosome
16
Position
66921679-66925536
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificpancreasCell SpecificCorticotrophsBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M56 Pid lpa4 pathway
- M15 Pid lysophospholipid pathway
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
22 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| RRAD | CSNK2A1 | P68400 | S | 299 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:9677319ProtMapper:9677319 |
| RRAD | CSNK2A1 | P68400 | S | 214 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:9677319ProtMapper:9677319KEA:9677319 |
| RRAD | CSNK2A1 | P68400 | S | 290 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:9677319ProtMapper:9677319KEA:9677319 |
| RRAD | CSNK2A1 | P68400 | S | 257 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:9677319ProtMapper:9677319KEA:7876254KEA:9677319 |
| RRAD | CSNK2A1 | P68400 | S | 273 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:9677319ProtMapper:9677319KEA:7876254KEA:9677319 |
| RRAD | PRKCB | P05771 | S | 290 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:9677319ProtMapper:9677319KEA:9677319 |
| RRAD | PRKCB | P05771 | S | 214 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:9677319ProtMapper:9677319KEA:9677319 |
| RRAD | PRKCB | P05771 | S | 273 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | SIGNOR:9677319ProtMapper:9677319 |
| RRAD | PRKCB | P05771 | S | 257 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:9677319ProtMapper:9677319KEA:7876254KEA:9677319 |
| RRAD | PRKCB | P05771 | S | 299 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:9677319ProtMapper:9677319KEA:9677319 |
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Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KCC2G | Q13555 | RAD | P55042 | Yes | No | No | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | ProtMapper:9677319ProtMapper:7876254HINT:9115241KEA:7876254KEA:9677319SIGNOR:9677319HINT:9677319HPRD:9677319HPRD:7876254 |
| CSK21 | P68400 | RAD | P55042 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:9677319PhosphoSite:9677319ProtMapper:7876254KEA:7876254KEA:9677319SIGNOR:9677319HPRD:9677319HPRD:7876254 |
| KPCB | P05771 | RAD | P55042 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | ProtMapper:9677319ProtMapper:7876254KEA:7876254KEA:9677319SIGNOR:9677319HPRD:9677319HPRD:7876254 |
| KPCA | P17252 | RAD | P55042 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDHINTPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:9677319ProtMapper:7876254KEA:7876254KEA:9677319HINT:7876254SIGNOR:9677319HINT:9677319HPRD:9677319HPRD:7876254 |
| KAPCA | P17612 | RAD | P55042 | Yes | No | No | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTKEABioGRIDHPRD_KEASIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:9677319ProtMapper:7876254BioGRID:7876254KEA:7876254KEA:9677319HINT:7876254SIGNOR:9677319HINT:9677319HPRD:9677319HPRD:7876254 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
308
Mass
33,245
Sequence
MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGALTAAAAGTGTQGPRLDWPEDSEDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL
3D Structural Models
Helix
104..111; 155..159; 174..189; 208..210; 215..224; 234..236; 240..254
Beta Strand
93..99; 126..133; 136..144; 164..170; 198..203; 228..231
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
1..16; Gly residues; 48..68; Low complexity
Region
1..88; Disordered; 278..297; Calmodulin-binding
Protein Families
- Small GTPase superfamily
- RGK family
Sequence Similarities
Belongs to the small GTPase superfamily. RGK family.
Clinical Relevance
Antibody
Interaction Protein
ENSG00000166946
Interaction Count
1
Interaction Dataset
intact_biogrid