Protein detail
AQP5
Aquaporin-5 (AQP-5)
Entry name AQP5 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 6 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Aquaporin-5 (AQP-5)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Potential drug targets
Transmembrane
13..33; Helical; 40..60; Helical; 88..108; Helical; 127..147; Helical; 159..179; Helical; 204..224; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Description
Aquaporin 5
Chromosome
12
Position
49961872-49965682
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization8
Tissue SpecificovaryCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specifichippocampal CA1-3Blood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted to extracellular matrixSecretome FunctionDevelopmental protein
Function & Pathway7
Protein Function (4)
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Potential drug targets
Cellular Component (7)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence38
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| AQP5 | PRKACA | P17612 | S | 156 | phosphorylation | PhosphoSite_MIMPMIMPSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:26569106 |
Ligand-Receptor Signaling (33)
33 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellTalkDB | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| aquaporin | transporter | HGNC | No | Yes | No | No | No |
| transporter | transporter | HGNC | No | Yes | No | No | No |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KAPCA | P17612 | AQP5 | P55064 | Yes | Yes | No | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:18478076SIGNOR:26569106PhosphoSite:29384694PhosphoSite:26569106 |
| AQP5 | P55064 | COMPLEX:P11802_P24385 | Yes | Yes | No | SIGNOR | SIGNOR:18583321 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 38716512 |
Sequence, Structure & Domains11
Sequences
Length
265
Mass
28,292
Sequence
MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR
3D Structural Models
Turn
115..118; 233..235
Helix
2..5; 8..32; 42..64; 70..78; 84..108; 111..114; 128..150; 161..180; 186..196; 203..223; 236..239
Beta Strand
36..38; 80..82; 124..126
3D Structure
X-ray crystallography (4)
Domain & Motif Annotations
Motif
69..71; NPA 1; 185..187; NPA 2
Domain (CC)
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Protein Families
MIP/aquaporin (TC 1.A.8) family
Sequence Similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Clinical Relevance3
Disease Involvement (2)
Disease variantPalmoplantar keratoderma
Drugs (31)
[125I][MEPHE7]NKBSB 235375PAVINETANTN',2-DIPHENYLQUINOLINE-4-CARBOHYDRAZIDE 8MTALNETANTGSK 256471NEUROKININ ASENKTIDEGR138676SCH 206272N′,2-DIPHENYLQUINOLINE-4-CARBOHYDRAZIDESB 218795SAREDUTANTFK 224KASSININ[PHE(ME)7]NEUROKININ B[PRO7]NEUROKININ BPD157672OSANETANTFEZOLINETANTSSR 146977ELEDOISINSB 222200NEUROKININ BSUBSTANCE PPD 161182GSK 172981HEMOKININ 1PD 154740HG2+
Antibody