Protein detail

PAR2

Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]

Protein symbol PAR2	UniProt ID P55085	EVMP score 0.50
Frequency 2	Transmembrane count 7	Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

G-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

72..101; Helical; Name=1; 109..137; Helical; Name=2; 150..177; Helical; Name=3; 184..211; Helical; Name=4; 236..269; Helical; Name=5; 278..317; Helical; Name=6; 324..347; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000164251

Entrez Gene Symbol

F2RL1

Gene Synonym

GPR11PAR2

Gene Description

F2R like trypsin receptor 1

Chromosome

Position

76818933-76835315

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificCytotrophoblastsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificnon-classical monocyteSecretome LocationSecreted to extracellular matrixSecretome FunctionOther

Function & Pathway

Protein Function

Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M232 Pid ecadherin stabilization pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

29 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
F2RL1	PRTN3	P24158	V	76	cleavage	SIGNOR	SIGNOR:10978167
F2RL1	PRTN3	P24158	T	74	cleavage	SIGNOR	SIGNOR:10978167
F2RL1	CTSG	P08311	F	59	cleavage	SIGNOR	SIGNOR:10978167
F2RL1	CTSG	P08311	L	38	cleavage	SIGNOR	SIGNOR:10978167
F2RL1	CTSG	P08311	F	64	cleavage	SIGNOR	SIGNOR:10978167
F2RL1	PRSS2	P07478	R	36	cleavage	SIGNOR	SIGNOR:10978167
F2RL1	PRSS2	P07478	K	34	cleavage	SIGNOR	SIGNOR:10978167
F2RL1	PRSS3	P35030	R	36	cleavage	SIGNOR	SIGNOR:10978167
F2RL1	PRSS3	P35030	K	34	cleavage	SIGNOR	SIGNOR:10978167
F2RL1	PRSS1	P07477	K	34	cleavage	SIGNOR	SIGNOR:10978167

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Ligand-Receptor Signaling

54 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No

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Regulatory Interaction Network

21 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PAR2	P55085	GNAQ	P50148	Yes	Yes	No	WangCui2007SIGNORCA1	CA1:9349532 SIGNOR:31160049
TRY1	P07477	PAR2	P55085	Yes	Yes	No	CellChatDBSIGNORCui2007CA1Wang	SIGNOR:10978167 CA1:9349532
PRTN3	P24158	PAR2	P55085	Yes	No	Yes	HPRDSIGNOR	SIGNOR:10978167 HPRD:10978167
CATG	P08311	PAR2	P55085	Yes	Yes	Yes	CellChatDBWangSIGNORHPRD	SIGNOR:10978167 HPRD:10978167
TRY2	P07478	PAR2	P55085	Yes	Yes	No	CellChatDBWangSIGNOR	SIGNOR:10978167
ELNE	P08246	PAR2	P55085	Yes	No	Yes	HPRDSIGNOR	SIGNOR:10978167 HPRD:10978167
PAR2	P55085	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
PAR2	P55085	GNAS3	O95467	Yes	Yes	No	SIGNOR	SIGNOR:31160049
PAR2	P55085	ALEX	P84996	Yes	Yes	No	SIGNOR	SIGNOR:31160049
PAR2	P55085	GNAS2	P63092	Yes	Yes	No	SIGNOR	SIGNOR:31160049

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Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	1	39120316

Sequence, Structure & Domains

Sequences

Length

397

Mass

44,126

Sequence

MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY

3D Structural Models

Turn

219..222

Helix

63..68; 72..75; 77..102; 109..125; 128..136; 145..178; 186..205; 207..210; 233..235; 236..249; 252..269; 279..298; 301..316; 323..332; 333..335; 336..347; 349..358

Beta Strand

215..218; 223..229

3D Structure

Electron microscopy (4); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

383..397; Low complexity

Region

373..397; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Drug Targets

Clinical trial target

Drugs

ERYTHROMYCIN TORIN 2 AC264613 TETRACYCLINE ROXITHROMYCIN AC-55541 CLARITHROMYCIN DOXYCYCLINE ANHYDROUS DEXAMETHASONE MACROLIDE ANTIBIOTIC MINOCYCLINE

Antibody

CAB012989 HPA014091

Interaction Protein

ENSG00000121022ENSG00000171867ENSG00000174437ENSG00000174915ENSG00000204388

Interaction Count

Interaction Dataset

intact_biogridintact_biogrid_bioplex