Protein detail
PAR2
Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
Protein symbol PAR2 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]
Protein Class
G-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
72..101; Helical; Name=1; 109..137; Helical; Name=2; 150..177; Helical; Name=3; 184..211; Helical; Name=4; 236..269; Helical; Name=5; 278..317; Helical; Name=6; 324..347; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
GPR11PAR2
Gene Description
F2R like trypsin receptor 1
Chromosome
5
Position
76818933-76835315
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificCytotrophoblastsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificnon-classical monocyteSecretome LocationSecreted to extracellular matrixSecretome FunctionOther
Function & Pathway
Protein Function
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
- GO:0001965 G-protein alpha-subunit binding
- GO:0002020 protease binding
- GO:0004930 G protein-coupled receptor activity
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0015057 thrombin-activated receptor activity
- GO:0031681 G-protein beta-subunit binding
- GO:0038023 signaling receptor activity
KEGG
Reactome
Canonical Pathways
M232 Pid ecadherin stabilization pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
29 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| F2RL1 | PRSS1 | P07477 | R | 36 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2RL1 | ELANE | P08246 | V | 53 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2RL1 | ELANE | P08246 | V | 48 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2RL1 | ELANE | P08246 | V | 58 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2RL1 | ELANE | P08246 | V | 76 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2RL1 | ELANE | P08246 | V | 42 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2RL1 | ELANE | P08246 | T | 74 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2RL1 | CAPN1 | P07384 | F | 59 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2RL1 | PLG | P00747 | R | 36 | cleavage | HPRD | HPRD:9020112HPRD:12604689HPRD:10978167 |
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Ligand-Receptor Signaling
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
Regulatory Interaction Network
21 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PAR2 | P55085 | GNAS1 | Q5JWF2 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| CAN2 | P17655 | PAR2 | P55085 | Yes | No | Yes | HPRDSIGNOR | SIGNOR:10978167HPRD:10978167 |
| PAR2 | P55085 | GNA15 | P30679 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PAR2 | P55085 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| TRY3 | P35030 | PAR2 | P55085 | Yes | Yes | No | CellChatDBWangSIGNOR | SIGNOR:10978167 |
| PAR2 | P55085 | GNAO | P09471 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PAR2 | P55085 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| TRYB1 | Q15661 | PAR2 | P55085 | Yes | Yes | No | CellinkerSIGNOR | Cellinker:9020112SIGNOR:21999702 |
| THRB | P00734 | PAR2 | P55085 | Yes | Yes | No | iTALKSIGNORHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerSTRING_talklrFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020LRdb | LRdb:11356985LRdb:11connectomeDB2020:10978167HPRD:10978167HPMR:11356985SIGNOR:11356985connectomeDB2020:11356985Baccin2019:1135698510978160Cellinker:11356985CellTalkDB:11356985 |
| CAN1 | P07384 | PAR2 | P55085 | Yes | No | Yes | HPRDSIGNOR | SIGNOR:10978167HPRD:10978167 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography | Mass spectrometry | 1 | 39120316 |
Sequence, Structure & Domains
Sequences
Length
397
Mass
44,126
Sequence
MRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
3D Structural Models
Turn
219..222
Helix
63..68; 72..75; 77..102; 109..125; 128..136; 145..178; 186..205; 207..210; 233..235; 236..249; 252..269; 279..298; 301..316; 323..332; 333..335; 336..347; 349..358
Beta Strand
215..218; 223..229
3D Structure
Electron microscopy (4); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
383..397; Low complexity
Region
373..397; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Drug Targets
Clinical trial target
Drugs
Interaction Protein
ENSG00000121022ENSG00000171867ENSG00000174437ENSG00000174915ENSG00000204388
Interaction Count
5
Interaction Dataset
intact_biogridintact_biogrid_bioplex