Protein detail
AQP4
Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)
Entry name AQP4 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 6 | Protein classification Human disease related genesMetabolic proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)
Protein Class (4)
Human disease related genesMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function (2)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Transporters:Transporter channels and pores
Transmembrane
37..57; Helical; 70..89; Helical; 116..136; Helical; 156..176; Helical; 185..205; Helical; 232..252; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
AQP-4hAQP4MIWC
Gene Description
Aquaporin 4
Chromosome
18
Position
26852043-26865771
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization6
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function (2)
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Transporters:Transporter channels and pores
Cellular Component (8)
Molecular Function (3)
Biological Process (3)
Reactome (4)
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence58
Enzyme-Mediated Modification (15)
15 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| AQP4 | CSNK2A2 | P19784 | S | 316 | phosphorylation | phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:11742978KEA:11742978ProtMapper:11742978 |
| AQP4 | CSNK2A2 | P19784 | S | 285 | phosphorylation | phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:11742978KEA:11742978ProtMapper:11742978 |
| AQP4 | CSNK2A2 | P19784 | S | 276 | phosphorylation | phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:11742978KEA:11742978ProtMapper:11742978 |
| AQP4 | CSNK2A2 | P19784 | S | 254 | phosphorylation | KEA | KEA:11742978 |
| AQP4 | CSNK2A2 | P19784 | S | 263 | phosphorylation | KEA | KEA:11742978 |
| AQP4 | CSNK2A2 | P19784 | S | 294 | phosphorylation | KEA | KEA:11742978 |
| AQP4 | CSNK2A1 | P68400 | S | 316 | phosphorylation | phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:11742978KEA:11742978ProtMapper:11742978 |
| AQP4 | CSNK2A1 | P68400 | S | 276 | phosphorylation | phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:11742978KEA:11742978ProtMapper:11742978 |
| AQP4 | CSNK2A1 | P68400 | S | 285 | phosphorylation | phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:11742978KEA:11742978ProtMapper:11742978 |
| AQP4 | CSNK2A1 | P68400 | S | 254 | phosphorylation | KEA | KEA:11742978 |
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Ligand-Receptor Signaling (36)
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OPM | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| peripheral | peripheral | UniProt_topology | No | No | No | No | No |
| peripheral | peripheral | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | LOCATE | No | No | No | No | No |
Regulatory Interaction Network (5)
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CSK21 | P68400 | AQP4 | P55087 | Yes | No | Yes | phosphoELM_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | SIGNOR:11742978KEA:11742978ProtMapper:11742978HPRD:11742978 |
| COMPLEX:O60941_P11532_P24043_P29475_P56539_Q13326_Q13424_Q13425_Q13884_Q14118_Q16585_Q16586_Q92629_Q9NSN8_Q9NY99_Q9Y4J8 | AQP4 | P55087 | Yes | Yes | No | SIGNOR | SIGNOR:22626543 | |
| CSK22 | P19784 | AQP4 | P55087 | Yes | No | Yes | phosphoELM_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | SIGNOR:11742978KEA:11742978ProtMapper:11742978HPRD:11742978 |
| KPCA | P17252 | AQP4 | P55087 | Yes | No | No | PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:19761816 |
| KAPCA | P17612 | AQP4 | P55087 | Yes | No | No | iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:26013827 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains12
Sequences
Length
323
Mass
34,830
Sequence
MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=AQP4-M1; IsoId=P55087-1; Sequence=Displayed; Name=1; Synonyms=AQP4-M23; IsoId=P55087-2; Sequence=VSP_003232
Alternative Sequence
1..22; Missing (in isoform 1)
3D Structural Models
Turn
59..63; 143..146; 228..231
Helix
33..55; 70..92; 98..106; 112..136; 139..142; 156..177; 189..208; 214..224; 232..250
3D Structure
Electron microscopy (3); X-ray crystallography (1)
Domain & Motif Annotations
Motif
97..99; NPA 1; 213..215; NPA 2
Domain (CC)
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Protein Families
MIP/aquaporin (TC 1.A.8) family
Sequence Similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Clinical Relevance3
Disease Involvement
Disease variant
Drugs (39)
R396NEPADUTANTTALNETANTSCH 206272SB 414240MEN 10376GR94800INEBILIZUMAB-CDONZONISAMIDESAREDUTANTTOPIRAMATE[&BETAALA8]NEUROKININ A-(4-10)MEN10627[PHE(ME)7]NEUROKININ BGR 159897[125I]NKA (HUMAN, MOUSE, RAT)ACETAZOLAMIDEZM 253270ZM-274773SUMATRIPTANACETYLSULFANILAMIDESUBSTANCE PYM44778NEUROKININ BYM49598GR100679SATRALIZUMABLAMOTRIGINEOSANETANTIBODUTANTETHOXZOLAMIDEPHENYTOIN SODIUMHEMOKININ 1ECULIZUMAB[3H]GR100679YM44781NEUROKININ AFK-888
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37438638 | Extracellular Vesicles Play a Central Role in Cerebral Venous Disease-Associated Brain Atrophy. | No abstract available |