Protein detail
AQP4
Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)
Protein symbol AQP4 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 6 | Protein classification Human disease related genesMetabolic proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Aquaporin-4 (AQP-4) (Mercurial-insensitive water channel) (MIWC) (WCH4)
Protein Class
Human disease related genesMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Transporters:Transporter channels and pores
Transmembrane
37..57; Helical; 70..89; Helical; 116..136; Helical; 156..176; Helical; 185..205; Helical; 232..252; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
AQP-4hAQP4MIWC
Gene Description
Aquaporin 4
Chromosome
18
Position
26852043-26865771
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- Transporters:Transporter channels and pores
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
15 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| AQP4 | CSNK2A1 | P68400 | S | 263 | phosphorylation | KEA | KEA:11742978 |
| AQP4 | CSNK2A1 | P68400 | S | 294 | phosphorylation | KEA | KEA:11742978 |
| AQP4 | PRKACA | P17612 | S | 276 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| AQP4 | PRKCA | P17252 | S | 180 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| AQP4 | PRKDC | P78527 | S | 285 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling
36 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | DGIdb | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| aquaporin | transporter | HGNC | No | Yes | No | No | No |
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Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CSK21 | P68400 | AQP4 | P55087 | Yes | No | Yes | phosphoELM_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | SIGNOR:11742978KEA:11742978ProtMapper:11742978HPRD:11742978 |
| COMPLEX:O60941_P11532_P24043_P29475_P56539_Q13326_Q13424_Q13425_Q13884_Q14118_Q16585_Q16586_Q92629_Q9NSN8_Q9NY99_Q9Y4J8 | AQP4 | P55087 | Yes | Yes | No | SIGNOR | SIGNOR:22626543 | |
| CSK22 | P19784 | AQP4 | P55087 | Yes | No | Yes | phosphoELM_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | SIGNOR:11742978KEA:11742978ProtMapper:11742978HPRD:11742978 |
| KPCA | P17252 | AQP4 | P55087 | Yes | No | No | PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:19761816 |
| KAPCA | P17612 | AQP4 | P55087 | Yes | No | No | iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:26013827 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
323
Mass
34,830
Sequence
MSDRPTARRWGKCGPLCTRENIMVAFKGVWTQAFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVHVIDVDRGEEKKGKDQSGEVLSSV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=2; Synonyms=AQP4-M1; IsoId=P55087-1; Sequence=Displayed; Name=1; Synonyms=AQP4-M23; IsoId=P55087-2; Sequence=VSP_003232
Alternative Sequence
1..22; Missing (in isoform 1)
3D Structural Models
Turn
59..63; 143..146; 228..231
Helix
33..55; 70..92; 98..106; 112..136; 139..142; 156..177; 189..208; 214..224; 232..250
3D Structure
Electron microscopy (3); X-ray crystallography (1)
Domain & Motif Annotations
Motif
97..99; NPA 1; 213..215; NPA 2
Domain (CC)
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Protein Families
MIP/aquaporin (TC 1.A.8) family
Sequence Similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Clinical Relevance
Disease Involvement
Disease variant
Drugs
R396NEPADUTANTTALNETANTSCH 206272SB 414240MEN 10376GR94800INEBILIZUMAB-CDONZONISAMIDESAREDUTANTTOPIRAMATE[&BETAALA8]NEUROKININ A-(4-10)MEN10627[PHE(ME)7]NEUROKININ BGR 159897[125I]NKA (HUMAN, MOUSE, RAT)ACETAZOLAMIDEZM 253270ZM-274773SUMATRIPTANACETYLSULFANILAMIDESUBSTANCE PYM44778NEUROKININ BYM49598GR100679SATRALIZUMABLAMOTRIGINEOSANETANTIBODUTANTETHOXZOLAMIDEPHENYTOIN SODIUMHEMOKININ 1ECULIZUMAB[3H]GR100679YM44781NEUROKININ AFK-888