Protein detail
CADH6
Cadherin-6 (Kidney cadherin) (K-cadherin)
Protein symbol CADH6 | UniProt ID | EVMP score 0.63 |
Frequency 7 | Transmembrane count 1 | Protein classification Plasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
Cadherin-6 (Kidney cadherin) (K-cadherin)
Protein Class
Plasma proteinsPredicted membrane proteins
Transmembrane
616..636; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
Cadherin 6
Chromosome
5
Position
31193686-31329146
Frequency
7
EVMP Score
0.63
Fluorescence & Localization
Function & Pathway
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CADH6 | P55285 | CTNB1 | P35222 | Yes | Yes | No | SIGNORBioGRID | BioGRID:10207020SIGNOR:21255999 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
790
Mass
88,309
Sequence
MRTYRYFLLLFWVGQPYPTLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRRTPTARDNTDVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYGGVDSDKDS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55285-1; Sequence=Displayed; Name=2; IsoId=P55285-2; Sequence=VSP_000636, VSP_000637
Alternative Sequence
628..663; VTVVLFAALRRQRKKEPLIISKEDIRDNIVSYNDEG -> GKLVLPASYLPMVRGSHCYCDTLDLSASPIKAYSLI (in isoform 2); 664..790; Missing (in isoform 2)
3D Structural Models
Turn
529..531; 558..560
Beta Strand
495..497; 505..512; 524..527; 532..534; 536..541; 543..551; 562..571; 573..576; 579..589
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
269..279; Polar residues
Domain (CC)
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain (FT)
54..159; Cadherin 1; 160..268; Cadherin 2; 269..383; Cadherin 3; 384..486; Cadherin 4; 487..608; Cadherin 5
Region
259..288; Disordered