Protein detail
CAD15
Cadherin-15 (Cadherin-14) (Muscle cadherin) (M-cadherin)
Protein symbol CAD15 | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted membrane proteins |
Basic Information
Protein Names
Cadherin-15 (Cadherin-14) (Muscle cadherin) (M-cadherin)
Protein Class
Disease related genesHuman disease related genesPredicted membrane proteins
Protein Function
- Disease related genes
- Human disease related genes:Other diseases:Mental and behavioural disorders
Transmembrane
607..626; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CDH14CDH3
Gene Description
Cadherin 15
Chromosome
16
Position
89171748-89195492
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificNeutrophils
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Other diseases:Mental and behavioural disorders
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| type1_classical_cadherin | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CAD15 | P55291 | CDON | Q4KMG0 | Yes | Yes | No | HPRDSIGNOR | SIGNOR:12634428HPRD:12634428 |
| CAD15 | P55291 | CTNB1 | P35222 | Yes | Yes | No | HPRDHINTSIGNOR | HINT:36950384SIGNOR:21255999HINT:9545347HPRD:9545347 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
814
Mass
88,916
Sequence
MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYGHPCGLEYGARWDHQAREGLSPGALLPRHRGRTA
3D Structural Models
Domain & Motif Annotations
Domain (CC)
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.
Domain (FT)
61..152; Cadherin 1; 153..260; Cadherin 2; 261..375; Cadherin 3; 376..481; Cadherin 4; 482..590; Cadherin 5
Region
636..663; Disordered; 676..703; Disordered
Clinical Relevance
Disease Involvement
Disease variantIntellectual disability