Protein detail

SH3BG

SH3 domain-binding glutamic acid-rich protein (SH3BGR protein) (21-glutamic acid-rich protein) (21-GARP)

Protein symbol SH3BG	UniProt ID P55822	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

SH3 domain-binding glutamic acid-rich protein (SH3BGR protein) (21-glutamic acid-rich protein) (21-GARP)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000185437

Entrez Gene Symbol

SH3BGR

Gene Synonym

21-GARP

Gene Description

SH3 domain binding glutamate rich protein

Chromosome

Position

39445855-39515506

Frequency

EVMP Score

0.38

Fluorescence & Localization

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005737 cytoplasm

Molecular Function

Biological Process

Canonical Pathways

M3008 Naba ecm glycoproteins
M5884 Naba core matrisome
M5889 Naba matrisome

Mediation Categories

Other mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AGFG1 AGFG2 KHDC4 LAP3 SH3BGRL STARD7	O75368 O95081 P28838 P52594 Q7Z7F0 Q9NQZ5	0:0:0:0:0:0	hu.MAP2
HNRNPL HYPK MANF NAA10 NAA11 NAA15 NAA16 NAA50 PLCB3 RIN2 SH3BGRL TOMM34 TSGA10IP ZYG11B	O75368 P14866 P41227 P55145 Q01970 Q15785 Q3SY00 Q6N069 Q8WYP3 Q9BSU3 Q9BXJ9 Q9C0D3 Q9GZZ1 Q9NX55	0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
CHORDC1 LAP3 PCYT2 SERPINH1 SH3BGRL	O75368 P28838 P50454 Q99447 Q9UHD1	0:0:0:0:0	hu.MAP2
LXN NSFL1C SH3BGRL	O75368 Q9BS40 Q9UNZ2	0:0:0	Havugimana2012	Havugimana2012:C_122
NANS SH3BGRL2	Q9NR45 Q9UJC5	0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation；Differential Ultracentrifugation；Density Gradient Centrifugation	Mass spectrometryWestern blotting	2	38731868 30608700

Sequence, Structure & Domains

Sequences

Length

239

Mass

26,086

Sequence

MPLLLLGETEPLKLERDCRSPVDPWAAASPDLALACLCHCQDLSSGAFPDRGVLGGVLFPTVEMVIKVFVATSSGSIAIRKKQQEVVGFLEANKIDFKELDIAGDEDNRRWMRENVPGEKKPQNGIPLPPQIFNEEQYCGDFDSFFSAKEENIIYSFLGLAPPPDSKGSEKAEEGGETEAQKEGSEDVGNLPEAQEKNEEEGETATEETEEIAMEGAEGEAEEEEETAEGEEPGEDEDS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55822-1; Sequence=Displayed; Name=2; IsoId=P55822-2; Sequence=VSP_045788

Alternative Sequence

1..111; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

167..185; Basic and acidic residues; 198..239; Acidic residues

Motif

124..130; SH3-binding

Region

159..239; Disordered

Protein Families

SH3BGR family

Sequence Similarities

Belongs to the SH3BGR family.

Clinical Relevance

Antibody

CAB003685