Protein detail

SH3BG

SH3 domain-binding glutamic acid-rich protein (SH3BGR protein) (21-glutamic acid-rich protein) (21-GARP)

Entry name SH3BG	UniProt ID P55822	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

SH3 domain-binding glutamic acid-rich protein (SH3BGR protein) (21-glutamic acid-rich protein) (21-GARP)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000185437

Entrez Gene Symbol

SH3BGR

Gene Synonym

21-GARP

Gene Description

SH3 domain binding glutamate rich protein

Chromosome

Position

39445855-39515506

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005737 cytoplasm

Molecular Function (2)

Biological Process (3)

Canonical Pathways (3)

M3008 Naba ecm glycoproteins
M5884 Naba core matrisome
M5889 Naba matrisome

Mediation Categories

Other mediation

Relations & Evidence9

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AGFG1 AGFG2 KHDC4 LAP3 SH3BGRL STARD7	O75368 O95081 P28838 P52594 Q7Z7F0 Q9NQZ5	0:0:0:0:0:0	hu.MAP2
HNRNPL HYPK MANF NAA10 NAA11 NAA15 NAA16 NAA50 PLCB3 RIN2 SH3BGRL TOMM34 TSGA10IP ZYG11B	O75368 P14866 P41227 P55145 Q01970 Q15785 Q3SY00 Q6N069 Q8WYP3 Q9BSU3 Q9BXJ9 Q9C0D3 Q9GZZ1 Q9NX55	0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
CHORDC1 LAP3 PCYT2 SERPINH1 SH3BGRL	O75368 P28838 P50454 Q99447 Q9UHD1	0:0:0:0:0	hu.MAP2
LXN NSFL1C SH3BGRL	O75368 Q9BS40 Q9UNZ2	0:0:0	Havugimana2012	Havugimana2012:C_122
NANS SH3BGRL2	Q9NR45 Q9UJC5	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation；Differential Ultracentrifugation；Density Gradient Centrifugation	Mass spectrometryWestern blotting	2	38731868 30608700

Sequence, Structure & Domains10

Sequences

Length

239

Mass

26,086

Sequence

MPLLLLGETEPLKLERDCRSPVDPWAAASPDLALACLCHCQDLSSGAFPDRGVLGGVLFPTVEMVIKVFVATSSGSIAIRKKQQEVVGFLEANKIDFKELDIAGDEDNRRWMRENVPGEKKPQNGIPLPPQIFNEEQYCGDFDSFFSAKEENIIYSFLGLAPPPDSKGSEKAEEGGETEAQKEGSEDVGNLPEAQEKNEEEGETATEETEEIAMEGAEGEAEEEEETAEGEEPGEDEDS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55822-1; Sequence=Displayed; Name=2; IsoId=P55822-2; Sequence=VSP_045788

Alternative Sequence

1..111; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

167..185; Basic and acidic residues; 198..239; Acidic residues

Motif

124..130; SH3-binding

Region

159..239; Disordered

Protein Families

SH3BGR family

Sequence Similarities

Belongs to the SH3BGR family.

Clinical Relevance1

Antibody

CAB003685

Supporting Publications1

PMID	Title	Abstract
36293200	Proteomic and miRNA Profiles of Exosomes Derived from Myometrial Tissue in Laboring Women.	Among them, seven proteins (SERPINE1, THBS1, MGAT1, VIM, FGB, FGG, and VWF) were differentially expressed both in the myometrial exosomes and tissues, three miRNAs (miR-363-3p, miR-203a-3p, and miR-205-5p) target 13 DE genes.