Protein detail
FCGRN
IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
Protein symbol FCGRN | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
Protein Class
FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Transmembrane
298..321; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
FcgammaRnFcRn
Gene Description
Fc gamma receptor and transporter
Chromosome
19
Position
49506816-49526428
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificsalivary glandCell SpecificBasal keratinocytesSingle-Nuclei Brain SpecificastrocyteSecretome LocationSecreted to bloodSecretome FunctionReceptor
Function & Pathway
Protein Function
- Predicted intracellular proteins
- FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
40 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
365
Mass
39,743
Sequence
MGVPRPQPWALGLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA
3D Structural Models
Turn
63..65; 80..82; 145..148; 267..269
Helix
72..76; 83..104; 123..125; 155..166; 170..179; 181..192; 194..197; 270..272
Beta Strand
29..39; 46..53; 56..62; 66..68; 107..109; 112..121; 127..135; 138..144; 149..151; 167..169; 204..211; 213..215; 216..229; 231..237; 240..243; 246..251; 253..255; 257..266; 273..279; 282..284; 286..288
3D Structure
Electron microscopy (6); X-ray crystallography (21)
Domain & Motif Annotations
Domain (FT)
202..289; Ig-like C1-type
Region
24..110; Alpha-1; 111..200; Alpha-2; 201..290; Alpha-3; 291..297; Connecting peptide
Protein Families
Immunoglobulin superfamily
Sequence Similarities
Belongs to the immunoglobulin superfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Phase 3; Phase 2; Approved
Drug Targets
FDA approved drug targets
Interaction Protein
ENSG00000166710
Interaction Count
1
Interaction Dataset
intact_biogrid_bioplex