Protein detail
GFRA1
GDNF family receptor alpha-1 (GDNF receptor alpha-1) (GDNFR-alpha-1) (GFR-alpha-1) (RET ligand 1) (TGF-beta-related neurotrophic factor receptor 1)
Protein symbol GFRA1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
GDNF family receptor alpha-1 (GDNF receptor alpha-1) (GDNFR-alpha-1) (GFR-alpha-1) (RET ligand 1) (TGF-beta-related neurotrophic factor receptor 1)
Protein Class
Disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
GDNFRGDNFRAGFR-ALPHA-1RET1LRETL1TRNR1
Gene Description
GDNF family receptor alpha 1
Chromosome
10
Position
116056925-116276803
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
Cellular Component
- GO:0005771 multivesicular body
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0019898 extrinsic component of membrane
- GO:0030424 axon
- GO:0043025 neuronal cell body
- GO:0043235 receptor complex
- GO:0070062 extracellular exosome
- GO:0098797 plasma membrane protein complex
Molecular Function
Biological Process
Reactome
- R-hsa-9830674 formation of the ureteric bud
- R-hsa-9830369 kidney development
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-419037 ncam1 interactions
- R-hsa-375165 ncam signaling for neurite out growth
- R-hsa-9675108 nervous system development
- R-hsa-8853659 ret signaling
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
49 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gpi_anchored | receptor | HPMR | No | Yes | No | Yes | Yes |
| growth_factor | receptor | ICELLNET | No | Yes | No | Yes | Yes |
| growth_factor_gdnf_family | receptor | ICELLNET | No | Yes | No | Yes | Yes |
| receptor | receptor | OmniPath | No | Yes | No | Yes | Yes |
| extracellular | extracellular | HPMR | No | No | No | Yes | Yes |
| extracellular | extracellular | DGIdb | No | No | No | Yes | Yes |
| extracellular | extracellular | OmniPath | No | No | No | Yes | Yes |
| intracellular | intracellular | LOCATE | No | No | No | Yes | Yes |
| intracellular | intracellular | ComPPI | No | No | No | Yes | Yes |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | Yes |
Regulatory Interaction Network
3 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
465
Mass
51,456
Sequence
MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPVQTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P56159-1; Sequence=Displayed; Name=2; IsoId=P56159-2; Sequence=VSP_001660
Alternative Sequence
140..144; Missing (in isoform 2)
3D Structural Models
3D Structure
Electron microscopy (1)
Domain & Motif Annotations
Repeat
25..113; 1; 150..238; 2; 239..342; 3
Protein Families
GDNFR family
Sequence Similarities
Belongs to the GDNFR family.