Protein detail

GFRA1

GDNF family receptor alpha-1 (GDNF receptor alpha-1) (GDNFR-alpha-1) (GFR-alpha-1) (RET ligand 1) (TGF-beta-related neurotrophic factor receptor 1)

Entry name GFRA1	UniProt ID P56159	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

GDNF family receptor alpha-1 (GDNF receptor alpha-1) (GDNFR-alpha-1) (GFR-alpha-1) (RET ligand 1) (TGF-beta-related neurotrophic factor receptor 1)

Protein Class (3)

Disease related genesPredicted intracellular proteinsPredicted membrane proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000151892

Entrez Gene Symbol

GFRA1

Gene Synonym (6)

GDNFRGDNFRAGFR-ALPHA-1RET1LRETL1TRNR1

Gene Description

GDNF family receptor alpha 1

Chromosome

Position

116056925-116276803

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization1

Function & Pathway6

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (10)

Molecular Function (6)

Biological Process (3)

Reactome (8)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence53

Ligand-Receptor Signaling (49)

49 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
gpi_anchored	receptor	HPMR	No	Yes	No	Yes	Yes
growth_factor	receptor	ICELLNET	No	Yes	No	Yes	Yes
growth_factor_gdnf_family	receptor	ICELLNET	No	Yes	No	Yes	Yes
receptor	receptor	OmniPath	No	Yes	No	Yes	Yes
extracellular	extracellular	HPMR	No	No	No	Yes	Yes
extracellular	extracellular	DGIdb	No	No	No	Yes	Yes
extracellular	extracellular	OmniPath	No	No	No	Yes	Yes
intracellular	intracellular	LOCATE	No	No	No	Yes	Yes
intracellular	intracellular	ComPPI	No	No	No	Yes	Yes
intracellular	intracellular	GO_Intercell	No	No	No	Yes	Yes

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
RET	P07949	GFRA1	P56159	Yes	Yes	No	WangPhosphoPointSIGNORHPRDHINTSignaLink3BioGRIDCellinkerSPIKE_LC	SIGNOR:10829012 SignaLink3:10829012 HINT:20473317 HINT:9192898 BioGRID:9192898 HINT:10829012 HINT:31535977 HPRD:10774729 SignaLink3:23331499 Cellinker:9883723 SPIKE_LC:16189514
NRTN	Q99748	GFRA1	P56159	Yes	Yes	No	iTALKSIGNORHINTHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbReactome_LRdbHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACEFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020LRdb	HINT:9407096LRdb:941SIGNOR:9182803 LRdb:9182803 Cellinker:9407096 connectomeDB2020:9182803 Cellinker:9182803 HINT:10829012 connectomeDB2020:9407096 CellTalkDB:9182803 HPRD:9407096Baccin2019:91828039407096
GDNF	P39905	GFRA1	P56159	Yes	Yes	No	iTALKKirouac2010SIGNORHINTUniProt_LRdbDIPHPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerSTRING_talklrFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020LRdb	LRdb:8674117 SIGNOR:9182803 Baccin2019:9482105 Cellinker:11544105 HINT:20473317 connectomeDB2020:14514671 connectomeDB2020:8674117 HINT:10829012 HINT:31535977 LRdb:9482105 CellTalkDB:14514671 Baccin2019:8674117 HPMR:11106404 LRdb:14514671 Cellinker:9482105 HINT:9407096 HPMR:14514671 Cellinker:14514671 Cellinker:8674117 HPRD:8674117 DIP:20473317 connectomeDB2020:9482105 HPRD:9482105 Baccin2019:14514671

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	27470641 30865381

Sequence, Structure & Domains9

Sequences

Length

465

Mass

51,456

Sequence

MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRVVPFISDVFQQVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEECLKFLNFFKDNTCLKNAIQAFGNGSDVTVWQPAFPVQTTTATTTTALRVKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGLGASSHITTKSMAAPPSCGLSPLLVLVVTALSTLLSLTETS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P56159-1; Sequence=Displayed; Name=2; IsoId=P56159-2; Sequence=VSP_001660

Alternative Sequence

140..144; Missing (in isoform 2)

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Repeat

25..113; 1; 150..238; 2; 239..342; 3

Protein Families

GDNFR family

Sequence Similarities

Belongs to the GDNFR family.

Clinical Relevance3

Disease Involvement

Disease variant

Drugs (3)

LIATERMIN NULL ANTISENSE OLIGONUCLEOTIDES

Antibody

HPA043829

Supporting Publications1

PMID	Title	Abstract
33799461	Proteomics Profiling of Neuron-Derived Small Extracellular Vesicles from Human Plasma: Enabling Single-Subject Analysis.	No abstract available