Protein detail
LEG4
Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4)
Entry name LEG4 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Galectin-4 (Gal-4) (Antigen NY-CO-27) (L-36 lactose-binding protein) (L36LBP) (Lactose-binding lectin 4)
Protein Class (3)
Cancer-related genesPlasma proteinsPredicted intracellular proteins
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
GAL4
Gene Description
Galectin 4
Chromosome
19
Position
38801671-38812945
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization1
Cell SpecificMelanocytes
Function & Pathway6
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component (4)
Molecular Function (3)
Biological Process (3)
Canonical Pathways (3)
- M159 Pid amb2 neutrophils pathway
- M174 Pid upa upar pathway
- M186 Pid pdgfrb pathway
Mediation Categories (2)
Immune mediationMetabolism mediation
Relations & Evidence11
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| galectin | secreted_receptor | Matrisome | Yes | No | No | No | No |
| secreted_receptor | secreted_receptor | OmniPath | Yes | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 38716512 |
Sequence, Structure & Domains9
Sequences
Length
323
Mass
35,941
Sequence
MAYVPAPGYQPTYNPTLPYYQPIPGGLNVGMSVYIQGVASEHMKRFFVNFVVGQDPGSDVAFHFNPRFDGWDKVVFNTLQGGKWGSEERKRSMPFKKGAAFELVFIVLAEHYKVVVNGNPFYEYGHRLPLQMVTHLQVDGDLQLQSINFIGGQPLRPQGPPMMPPYPGPGHCHQQLNSLPTMEGPPTFNPPVPYFGRLQGGLTARRTIIIKGYVPPTGKSFAINFKVGSSGDIALHINPRMGNGTVVRNSLLNGSWGSEEKKITHNPFGPGQFFDLSIRCGLDRFKVYANGQHLFDFAHRLSAFQRVDTLEIQGDVTLSYVQI
3D Structural Models
Turn
228..230; 241..244
Helix
130..132; 304..306
Beta Strand
12..14; 17..22; 32..38; 46..55; 60..67; 69..71; 73..80; 88..91; 100..107; 109..116; 119..125; 135..150; 187..189; 192..197; 206..213; 220..226; 233..240; 245..251; 273..280; 282..289; 292..298; 300..302; 309..315; 317..322
3D Structure
NMR spectroscopy (1); X-ray crystallography (12)
Domain & Motif Annotations
Domain (CC)
Contains two homologous but distinct carbohydrate-binding domains.
Domain (FT)
19..150; Galectin 1; 194..323; Galectin 2
Clinical Relevance2
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |