Protein detail
CLD6
Claudin-6 (Skullin)
Entry name CLD6 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 4 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information7
Protein Names
Claudin-6 (Skullin)
Protein Function
Predicted intracellular proteins
Transmembrane
8..28; Helical; 82..102; Helical; 117..137; Helical; 161..181; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
EVMP confidence score
0.38
Function & Pathway8
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function (4)
Biological Process (3)
KEGG (7)
Reactome (3)
Canonical Pathways
M211 Pid hedgehog 2pathway
Mediation Categories (4)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence25
Ligand-Receptor Signaling (24)
24 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | No | No | No |
| tight_junction | tight_junction | Zhong2015 | Yes | Yes | No | No | No |
| tight_junction | tight_junction | HGNC | Yes | Yes | No | No | No |
| claudin | tight_junction | Almen2009 | Yes | Yes | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains6
Sequences
Length
220
Mass
23,292
Sequence
MASAGMQILGVVLTLLGWVNGLVSCALPMWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLVALFGLLVYLAGAKCTTCVEEKDSKARLVLTSGIVFVISGVLTLIPVCWTAHAIIRDFYNPLVAEAQKRELGASLYLGWAASGLLLLGGGLLCCTCPSGGSQGPSHYMARYSTSAPAISRGPSEYPTKNYV
Domain & Motif Annotations
Region
219..220; Interactions with TJP1, TJP2 and TJP3
Protein Families
Claudin family
Sequence Similarities
Belongs to the claudin family.
Clinical Relevance2
Related Diseases
Biomarker
Phase 1