Protein detail
CLD12
Claudin-12
Protein symbol CLD12 | UniProt ID | EVMP score 0.25 |
Frequency 4 | Transmembrane count 4 | Protein classification Predicted membrane proteins |
Basic Information
Protein Names
Claudin-12
Protein Class
Predicted membrane proteins
Transmembrane
11..31; Helical; 88..108; Helical; 136..156; Helical; 175..195; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Description
Claudin 12
Chromosome
7
Position
90383721-90513402
Frequency
4
EVMP Score
0.25
Fluorescence & Localization
Tissue SpecificesophagusBrain Regional Specificchoroid plexusCell SpecificBreast secretory cellsBlood Cell SpecificeosinophilBlood Lineage Specificdendritic cells
Function & Pathway
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M290 Pid il12 stat4 pathway
- M88 Pid cd8 tcr pathway
- M34 Pid tcr pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | No | Yes | No |
| tight_junction | tight_junction | Ramilowski_location | Yes | Yes | No | Yes | No |
| tight_junction | tight_junction | Zhong2015 | Yes | Yes | No | Yes | No |
| tight_junction | tight_junction | HGNC | Yes | Yes | No | Yes | No |
| claudin | tight_junction | Almen2009 | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 27605433 |
Sequence, Structure & Domains
Sequences
Length
244
Mass
27,110
Sequence
MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVFSFDYAVYVTIASAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHTYSQPYSARSRLSAIEIDIPVVSHTT
3D Structural Models
Domain & Motif Annotations
Protein Families
Claudin family
Sequence Similarities
Belongs to the claudin family.
Clinical Relevance
Antibody