Protein detail
BACE1
Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)
Entry name BACE1 | UniProt ID | EVMP confidence score 0.63 |
Supporting publications (n) 6 | Transmembrane count 1 | Protein classification EnzymesPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)
Protein Class (4)
EnzymesPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- Enzymes
- Transporters:Accessory Factors Involved in Transport
- ENZYME proteins:Hydrolases
- Peptidases:Aspartic-type peptidases
Transmembrane
458..478; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
BACE
Gene Description
Beta-secretase 1
Chromosome
11
Position
117285232-117316259
Supporting publications (n)
6
EVMP confidence score
0.63
Fluorescence & Localization4
Tissue Specificparathyroid glandCell SpecificEpendymal cellsSingle-Nuclei Brain Specificastrocyte
Function & Pathway7
Protein Function (5)
- Predicted intracellular proteins
- Enzymes
- Transporters:Accessory Factors Involved in Transport
- ENZYME proteins:Hydrolases
- Peptidases:Aspartic-type peptidases
Cellular Component (20)
- GO:0005764 lysosome
- GO:0005768 endosome
- GO:0005769 early endosome
- GO:0005770 late endosome
- GO:0005771 multivesicular body
- GO:0005788 endoplasmic reticulum lumen
- GO:0005794 Golgi apparatus
- GO:0005802 trans-Golgi network
- GO:0005886 plasma membrane
- GO:0008021 synaptic vesicle
Page 1 of 2
Molecular Function (8)
Biological Process (3)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence55
Enzyme-Mediated Modification (15)
15 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| BACE1 | CDK5 | Q00535 | T | 252 | phosphorylation | Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:27044452ProtMapper:26317805ProtMapper:28469554 |
| BACE1 | ROCK2 | O75116 | S | 498 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| BACE1 | F2RL2 | O00254 | S | 498 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:28946017 |
| BACE1 | CHKA | P35790 | S | 498 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:11860271 |
| BACE1 | HRES1 | P13985 | T | 252 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:27044452ProtMapper:26317805 |
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Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | Surfaceome | Yes | No | No | Yes | No |
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
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Regulatory Interaction Network (10)
10 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| BACE1 | P56817 | A4 | P05067 | Yes | Yes | No | WangSIGNORHPRDHINTBioGRIDIntActSPIKE_LCSPIKE | BioGRID:28869759IntAct:12901838HINT:10531052HINT:31996371HPRD:10531052HINT:10677483SIGNOR:10931940IntAct:22801501HINT:30538620SPIKE:20418918HINT:12901838SPIKE_LC:20418918IntAct:10677483IntAct:32814053IntAct:30538620SIGNOR:28923680BioGRID:19251705HINT:22801501 |
| UBP8 | P40818 | BACE1 | P56817 | Yes | Yes | No | SIGNOR | SIGNOR:27302062 |
| FBX2 | Q9UK22 | BACE1 | P56817 | Yes | No | Yes | SIGNOR | SIGNOR:20854419 |
| CDK5 | Q00535 | BACE1 | P56817 | Yes | Yes | No | Sparser_ProtMapperiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:26317805PhosphoSite:26317805ProtMapper:31892243ProtMapper:26317805ProtMapper:27044452 |
| CHIP | Q9UNE7 | BACE1 | P56817 | Yes | No | Yes | SIGNOR | SIGNOR:25773675 |
| COMPLEX:Q00535_Q15078 | BACE1 | P56817 | Yes | Yes | No | SIGNOR | SIGNOR:26317805 | |
| COMPLEX:P62877_P63208_Q13616 | BACE1 | P56817 | Yes | No | Yes | SIGNOR | SIGNOR:20854419 | |
| KC1D | P48730 | BACE1 | P56817 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phosPhosphoSite_ProtMapper | HPRD-phos:11278841phosphoELM:11278841KEA:11860271ProtMapper:11278841HPRD:11278841SIGNOR:11278841KEA:11278841 |
| MK14 | Q16539 | BACE1 | P56817 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:26663083 |
| ROCK2 | O75116 | BACE1 | P56817 | Yes | No | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:24305806PhosphoSite:28946017PhosphoSite:15615712PhosphoSite:11860271PhosphoSite:11278841 |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_SC_Cluster70 | BACE1CTSDCTSENAPSANXF2BPGA3PGA4PGA5PRKAB2RENRTN1RTN2RTN3RTN4TCP11TCP11L1TCP11L2 | O43741O75298O95197O96009P00797P07339P0DJD7P0DJD8P0DJD9P14091P56817Q16799Q8N4U5Q8WWU5Q9GZY0Q9NQC3Q9NUJ3 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | Compleat | Compleat:HC1010 | |
| PAR4-BACE1 complex | BACE1PAWR | P56817Q96IZ0 | 1:1 | CompleatCORUM | Compleat:HC2801CORUM:4039 | 15671026 |
| BACE1 | P56817 | 2 | PDB | PDB:3l5cPDB:4frsPDB:3cibPDB:2hizPDB:3msjPDB:4x7iPDB:5he4PDB:3l5ePDB:5qd9PDB:3dm6PDB:5qd3PDB:4h3jPDB:4h1ePDB:1ym4PDB:3k5dPDB:4ybiPDB:3uqrPDB:5htzPDB:5hdvPDB:2qk5PDB:3h0bPDB:5qdaPDB:5he7PDB:6bfePDB:3lpjPDB:4fslPDB:5hu1PDB:5hduPDB:2qmdPDB:2f3ePDB:5he5PDB:5qcvPDB:5qd0PDB:5qcoPDB:6uvvPDB:3pi5PDB:4zsrPDB:2fdpPDB:7myiPDB:4k8sPDB:3l5dPDB:4dvfPDB:3n4lPDB:4djyPDB:5qd1PDB:4r91PDB:5qcuPDB:3ohhPDB:5qdcPDB:5qdbPDB:3lpiPDB:7myuPDB:2g94PDB:3kmxPDB:3kn0PDB:2qmfPDB:5qd2PDB:4djuPDB:4r95PDB:4djwPDB:4lxmPDB:4zsqPDB:4fsePDB:3ohfPDB:6uwvPDB:2qp8PDB:5hdxPDB:3l58PDB:6nv9PDB:1fknPDB:7myrPDB:5qcsPDB:4ke0PDB:4fs4PDB:5qcqPDB:4h3iPDB:1xn3PDB:5qcxPDB:2zhrPDB:6uwpPDB:4gidPDB:6uvyPDB:4tryPDB:3nshPDB:3r2fPDB:1xn2PDB:6dhcPDB:6uvpPDB:3cidPDB:5v0nPDB:4lxaPDB:3i25PDB:5dqcPDB:4d8cPDB:3skfPDB:4r8yPDB:6e3zPDB:4zspPDB:3k5gPDB:4r92PDB:4djvPDB:5qcpPDB:3ixjPDB:4h3gPDB:5qd7PDB:3tplPDB:3dv5PDB:3hvgPDB:3u6aPDB:6bfdPDB:3ckrPDB:2p83PDB:5hu0PDB:1ym2PDB:5qcwPDB:5qd4PDB:4d83PDB:1sgzPDB:5qcyPDB:4r93PDB:3ckpPDB:5qd5PDB:2f3fPDB:4djxPDB:3skgPDB:3ixkPDB:4i0iPDB:3lnkPDB:2qmgPDB:6nw3PDB:5qctPDB:4trwPDB:3k5fPDB:2vkmPDB:5qd8PDB:3cicPDB:3k5cPDB:5qddPDB:6bfxPDB:3lpkPDB:1m4hPDB:5qd6PDB:5hdzPDB:3kyrPDB:3l59PDB:3dv1PDB:4ha5PDB:5qcrPDB:2p4jPDB:4lxkPDB:3kmyPDB:2zjkPDB:4di2PDB:4zsmPDB:5hd0PDB:3l5bPDB:4h3fPDB:5mxdPDB:3l5fPDB:6od6PDB:3iviPDB:6bfwPDB:4k9hPDB:3qbhPDB:3duyPDB:3hw1PDB:4i0hPDB:4trzPDB:5qczPDB:6nv7PDB:2q11 | ||
| BACE1GGA1 | P56817Q9UJY5 | 4:4 | PDB | PDB:1ujjPDB:1ujkPDB:1py1 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains15
Sequences
Length
501
Mass
55,764
Sequence
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=A; Synonyms=BACE-1A, BAC-501; IsoId=P56817-1; Sequence=Displayed; Name=B; Synonyms=BACE-1B, BACE-I-476; IsoId=P56817-2; Sequence=VSP_005223; Name=C; Synonyms=BACE-1C, BACE-I-457; IsoId=P56817-3; Sequence=VSP_005222; Name=D; Synonyms=BACE-1D, BACE-I-432; IsoId=P56817-4; Sequence=VSP_005222, VSP_005223; Name=5; IsoId=P56817-5; Sequence=VSP_047092, VSP_047093; Name=6; IsoId=P56817-6; Sequence=VSP_047092, VSP_047093, VSP_005223
Alternative Sequence
1..20; MAQALPWLLLWMGAGVLPAH -> MVPFIYLQAHFTLCSGWSST (in isoform 5 and isoform 6); 21..120; Missing (in isoform 5 and isoform 6); 146..189; Missing (in isoform C and isoform D); 190..214; Missing (in isoform B, isoform D and isoform 6)
3D Structural Models
Turn
61..65; 71..73; 82..85; 149..152; 172..174; 257..260; 313..315; 333..335; 408..411
Helix
115..117; 185..187; 197..204; 224..229; 242..244; 278..282; 299..312; 320..323; 338..340; 363..366; 396..399; 440..443
Beta Strand
67..70; 74..81; 86..93; 99..102; 109..111; 122..132; 135..147; 155..168; 178..181; 188..190; 211..215; 233..239; 245..253; 264..269; 286..288; 294..298; 329..332; 344..349; 355..361; 367..370; 373..375; 379..383; 385..390; 392..394; 402..407; 412..418; 430..436
3D Structure
X-ray crystallography (431)
Domain & Motif Annotations
Motif
496..500; DXXLL
Domain (CC)
DXXLL motif is required for a proper endocytosis and retrograde transport to the trans-Golgi network, as well as for regulation of lysosomal degradation.; DOMAIN: The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP.
Domain (FT)
75..416; Peptidase A1
Region
39..58; Disordered; 479..501; Interaction with RTN3
Protein Families
Peptidase A1 family
Sequence Similarities
Belongs to the peptidase A1 family.
Clinical Relevance7
Related Diseases
Biomarker
Phase 3
Drugs (25)
Antibody
Interaction Protein (4)
ENSG00000100083ENSG00000103365ENSG00000125447ENSG00000142192
Interaction Count
4
Interaction Dataset
intact_biogrid
Supporting Publications6
| PMID | Title | Abstract |
|---|---|---|
| 31320591 | Exosomes regulate neurogenesis and circuit assembly. | No abstract available |
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No abstract available |
| 41201090 | Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma. | No abstract available |