Protein detail

HUNK

Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (B19) (Serine/threonine-protein kinase MAK-V)

Entry name HUNK	UniProt ID P57058	EVMP confidence score 0.38
Supporting publications (n) 4	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Hormonally up-regulated neu tumor-associated kinase (EC 2.7.11.1) (B19) (Serine/threonine-protein kinase MAK-V)

Protein Class (2)

EnzymesPredicted intracellular proteins

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:CAMK Ser/Thr protein kinases

Ensembl

ENSG00000142149

Entrez Gene Symbol

HUNK

Gene Description

Hormonally up-regulated Neu-associated kinase

Chromosome

Position

31873020-32044633

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization7

Tissue Specificheart muscleBrain Regional Specificchoroid plexusCell SpecificAdrenal medulla cellsSingle-Nuclei Brain SpecificfibroblastBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells

Function & Pathway6

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins
Kinases:CAMK Ser/Thr protein kinases

Cellular Component

GO:0005737 cytoplasm

Molecular Function (5)

Biological Process (3)

Canonical Pathways (3)

M31 Pid beta catenin deg pathway
M90 Pid wnt canonical pathway
M77 Pid wnt signaling pathway

Mediation Categories

Other mediation

Relations & Evidence9

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
HUNK	P57058	ITM2A	O43736	Yes	Yes	No	Sparser_ProtMapperSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:31438969 ProtMapper:31438969 PhosphoSite:31438969

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_SC_Cluster12	HUNK PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8 PSMB1 PSMB10 PSMB11 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMD3 PSME4 TTK	A5LHX3 O14818 O43242 P20618 P25786 P25787 P25788 P25789 P28062 P28065 P28066 P28070 P28072 P28074 P33981 P40306 P49720 P49721 P57058 P60900 Q14997 Q8TAA3 Q99436	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2893

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains8

Sequences

Length

714

Mass

79,686

Sequence

MPAAAGDGLLGEPAAPGGGGGAEDAARPAAACEGSFLPAWVSGVPRERLRDFQHHKRVGNYLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRHPNITQLLDILETENSYYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLLEPDPVKRPNIQQALANRWLNENYTGKVPCNVTYPNRISLEDLSPSVVLHMTEKLGYKNSDVINTVLSNRACHILAIYFLLNKKLERYLSGKSDIQDSLCYKTRLYQIEKYRAPKESYEASLDTWTRDLEFHAVQDKKPKEQEKRGDFLHRPFSKKLDKNLPSHKQPSGSLMTQIQNTKALLKDRKASKSSFPDKDSFGCRNIFRKTSDSNCVASSSMEFIPVPPPRTPRIVKKPEPHQPGPGSTGIPHKEDPLMLDMVRSFESVDRDDHVEVLSPSHHYRILNSPVSLARRNSSERTLSPGLPSGSMSPLHTPLHPTLVSFAHEDKNSPPKEEGLCCPPPVPSNGPMQPLGSPNCVKSRGRFPMMGIGQMLRKRHQSLQPSADRPLEASLPPLQPLAPVNLAFDMADGVKTQC

Domain & Motif Annotations

Compositional Bias

1..15; Low complexity; 437..461; Basic and acidic residues; 599..611; Low complexity

Domain (FT)

62..320; Protein kinase

Region

1..26; Disordered; 437..471; Disordered; 518..552; Disordered; 590..615; Disordered

Protein Families (3)

Protein kinase superfamily
CAMK Ser/Thr protein kinase family
SNF1 subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

Clinical Relevance4

Antibody (3)

HPA027232 HPA027295 HPA027372

Interaction Protein

ENSG00000133612

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications4

PMID	Title	Abstract
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No abstract available
38225453	Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40545963	Extracellular Vesicle Proteome Analysis Improves Diagnosis of Recurrence in Triple-Negative Breast Cancer.	No abstract available