Protein detail
RAB25
Ras-related protein Rab-25 (EC 3.6.5.2) (CATX-8)
Entry name RAB25 | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 37 | Transmembrane count | Protein classification Cancer-related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Ras-related protein Rab-25 (EC 3.6.5.2) (CATX-8)
Protein Class (2)
Cancer-related genesPredicted intracellular proteins
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CATX-8
Gene Description
RAB25, member RAS oncogene family
Chromosome
1
Position
156061160-156070504
Supporting publications (n)
37
EVMP confidence score
0.75
Fluorescence & Localization
Function & Pathway
Protein Function (2)
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function (4)
Biological Process (3)
Reactome (2)
Canonical Pathways (2)
- M69 Pid reelin pathway
- M163 Pid lis1 pathway
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence15
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Protein Complex Composition (7)
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| EVI5LRAB11ARAB11BRAB11FIP1RAB11FIP2RAB11FIP5RAB25SH3BP5 | O60239P57735P62491Q15907Q6WKZ4Q7L804Q96CN4Q9BXF6 | 0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| RAB11BRAB11FIP1RAB11FIP2RAB11FIP5RAB25SH3BP5SH3BP5L | O60239P57735Q15907Q6WKZ4Q7L804Q7L8J4Q9BXF6 | 0:0:0:0:0:0:0 | hu.MAP | |||
| RAB11BRAB25SH3BP5SH3BP5L | O60239P57735Q15907Q7L8J4 | 0:0:0:0 | hu.MAP | |||
| CHMLD2HGDHPOTEGRAB1ARAB25RAB3ARAB3IL1RAB3IPRABAC1STX5UBCYIF1B | P0CG48P20336P26374P57735P62820Q13190Q5BJH7Q6S5H5Q8N465Q8TBN0Q96QF0Q9UI14 | 1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4885 | ||
| D2HGDHGDI1RAB17RAB22ARAB25RAB33BRAB7ARABAC1TBC1D13UBCVPS33BYIF1BYIPF1YIPF5 | P0CG48P31150P51149P57735Q5BJH7Q8N465Q969M3Q9H082Q9H0T7Q9H267Q9NVG8Q9UI14Q9UL26Q9Y548 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9123 | ||
| RAB11ARAB11BRAB11FIP1RAB11FIP2RAB11FIP5RAB25 | P57735P62491Q15907Q6WKZ4Q7L804Q9BXF6 | 0:0:0:0:0:0 | hu.MAP2 | |||
| RAB11FIP2RAB25 | P57735Q7L804 | 2:2 | PDB | PDB:3tso |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
213
Mass
23,496
Sequence
MGNGTEEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGLERYRAITSAYYRGAVGALLVFDLTKHQTYAVVERWLKELYDHAEATIVVMLVGNKSDLSQAREVPTEEARMFAENNGLLFLETSALDSTNVELAFETVLKEIFAKVSKQRQNSIRTNAITLGSAQAGQEPGPGEKRACCISL
3D Structural Models
Turn
156..158
Helix
25..34; 78..82; 97..101; 103..111; 127..132; 137..146; 162..177
Beta Strand
11..19; 46..56; 59..68; 87..93; 119..125; 150..153
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Motif
35..49; Switch 1; 67..84; Switch 2
Domain (CC)
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Protein Families (2)
- Small GTPase superfamily
- Rab family
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.
Clinical Relevance
Supporting Publications37
| PMID | Title | Related sentences |
|---|---|---|
| 39290459 | Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease. | No related sentences available |
| 39443544 | Profiling of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma in a cross-sectional study. | No related sentences available |
| 39835386 | Comparison of nanoLC-MALDI-MS/MS with nanoLC-TIMS-MS/MS in the proteomic analysis of extracellular vesicles of bronchoalveolar lavage fluid. | No related sentences available |
| 39873726 | Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer. | No related sentences available |
| 40091455 | Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss. | No related sentences available |
| 40311616 | Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer. | No related sentences available |
| 41201090 | Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma. | No related sentences available |
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