Protein detail
CLD2
Claudin-2 (SP82)
Protein symbol CLD2 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 4 | Protein classification Disease related genesPredicted membrane proteins |
Basic Information
Protein Names
Claudin-2 (SP82)
Protein Class
Disease related genesPredicted membrane proteins
Protein Function
Disease related genes
Transmembrane
8..28; Helical; 82..102; Helical; 117..137; Helical; 163..183; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Description
Claudin 2
Chromosome
X
Position
106900164-106930861
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| ligand | ligand | CellCall | Yes | No | No | No | No |
| ligand | ligand | OmniPath | Yes | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
230
Mass
24,549
Sequence
MASLGLQLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRCTVFCQESRAKDRVAVAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIILCFSCSSQRNRSNYYDAYQAQPLATRSSPRPGQPPKVKSEFNSYSLTGYV
3D Structural Models
Helix
196..203
Beta Strand
210..218
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
220..230; Polar residues
Region
205..230; Disordered; 229..230; Interactions with TJP1, TJP2 and TJP3
Protein Families
Claudin family
Sequence Similarities
Belongs to the claudin family.