Protein detail

SNX16

Sorting nexin-16

Protein symbol
SNX16
UniProt ID
EVMP score
0.50
Frequency
4
Transmembrane count
Protein classification
Predicted intracellular proteins
Basic Information
Protein Names
Sorting nexin-16
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Entrez Gene Symbol
Gene Description
Sorting nexin 16
Chromosome
8
Position
81799581-81842866
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

4 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
SNX16P577686PDBPDB:5gw0PDB:5gw1
KIF6SNX16P57768Q6ZMV90:0hu.MAP2
HEATR5AKIF6SNX16P57768Q6ZMV9Q86XA90:0:0hu.MAP2
FEZ2HEATR5AKIF6SNX16P57768Q6ZMV9Q86XA9Q9UHY80:0:0:0hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometry53820710638113368401894974130796838207106
Sequence, Structure & Domains

Sequences

Length
344
Mass
39,167
Sequence
MATPYVPVPMPIGNSASSFTTNRNQRSSSFGSVSTSSNSSKGQLEDSNMGNFKQTSVPDQMDNTSSVCSSPLIRTKFTGTASSIEYSTRPRDTEEQNPETVNWEDRPSTPTILGYEVMEERAKFTVYKILVKKTPEESWVVFRRYTDFSRLNDKLKEMFPGFRLALPPKRWFKDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLDDPPGPFDSLEESRAFCETLEETNYRLQKELLEKQKEMESLKKLLSEKQLHIDTLENRIRTLSLEPEESLDVSETEGEQILKVESSALEVDQDVLDEESRADNKPCLSFSEPENAVSEIEVAEVAYDAEED
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P57768-1; Sequence=Displayed; Name=2; IsoId=P57768-2; Sequence=VSP_042944
Alternative Sequence
126..154; Missing (in isoform 2)

3D Structural Models

Helix
145..158; 178..197; 199..202; 205..211; 222..229; 233..276
Beta Strand
108..136; 138..144; 160..162; 171..173; 213..215
3D Structure
X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias
1..10; Pro residues; 14..26; Polar residues; 27..40; Low complexity; 41..66; Polar residues
Coiled Coil
223..278
Domain (CC)
The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
Domain (FT)
105..218; PX
Region
1..66; Disordered; 81..107; Disordered
Protein Families
Sorting nexin family
Sequence Similarities
Belongs to the sorting nexin family.
Clinical Relevance