Protein detail

RGS8

Regulator of G-protein signaling 8 (RGS8)

Entry name RGS8	UniProt ID P57771	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Regulator of G-protein signaling 8 (RGS8)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000135824

Entrez Gene Symbol

RGS8

Gene Synonym (3)

MGC119067MGC119068MGC119069

Gene Description

Regulator of G protein signaling 8

Chromosome

Position

182641816-182684587

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificMyonuclei

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (7)

Molecular Function (3)

Biological Process (3)

Reactome (2)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence12

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GNAI3 RGS8	P08754 P57771	2:2	PDB	PDB:2ode
	INPP4A NXT2 RGS8	P57771 Q96PE3 Q9NPJ8	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	39123364

Sequence, Structure & Domains9

Sequences

Length

180

Mass

20,917

Sequence

MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P57771-1; Sequence=Displayed; Name=2; IsoId=P57771-2; Sequence=VSP_036421

Alternative Sequence

1..9; MAALLMPRR -> MWNTLTRSLSDHPVGKDPQAMRTGQRQ (in isoform 2)

3D Structural Models

Turn

53..55; 140..143; 170..172

Helix

47..52; 57..61; 64..76; 81..92; 98..112; 125..134; 144..156; 158..163; 166..169

3D Structure

X-ray crystallography (3)

Domain & Motif Annotations

Domain (FT)

56..171; RGS

Clinical Relevance2

Drugs

NULL

Antibody

HPA076764

Supporting Publications2

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available