Protein detail
NRX1B
Neurexin-1-beta (Neurexin I-beta)
Entry name NRX1B | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 11 | Transmembrane count 1 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Neurexin-1-beta (Neurexin I-beta)
Protein Function (6)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Transmembrane
397..417; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
11
EVMP confidence score
0.60
Function & Pathway
Protein Function (6)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Cellular Component (16)
- GO:0005730 nucleolus
- GO:0005783 endoplasmic reticulum
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0030139 endocytic vesicle
- GO:0031594 neuromuscular junction
- GO:0031965 nuclear membrane
- GO:0031982 vesicle
- GO:0042734 presynaptic membrane
- GO:0042995 cell projection
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Molecular Function (12)
- GO:0004888 transmembrane signaling receptor activity
- GO:0005102 signaling receptor binding
- GO:0005105 type 1 fibroblast growth factor receptor binding
- GO:0005246 calcium channel regulator activity
- GO:0005509 calcium ion binding
- GO:0005515 protein binding
- GO:0033130 acetylcholine receptor binding
- GO:0038023 signaling receptor activity
- GO:0046872 metal ion binding
- GO:0048306 calcium-dependent protein binding
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Reactome (5)
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence135
Enzyme-Mediated Modification (6)
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| NRXN1 | CASK | O14936 | S | 425 | phosphorylation | PhosphoSite | |
| NRXN1 | CASK | O14936 | S | 424 | phosphorylation | PhosphoSite | |
| NRXN1 | CASK | O14936 | S | 428 | phosphorylation | PhosphoSite | |
| NRXN1 | CASK | O14936 | S | 1,529 | phosphorylation | MIMPPhosphoSite_MIMP | |
| NRXN1 | CASK | O14936 | S | 1,530 | phosphorylation | MIMPPhosphoSite_MIMP | |
| NRXN1 | CASK | O14936 | S | 1,533 | phosphorylation | MIMPPhosphoSite_MIMP |
Ligand-Receptor Signaling (106)
106 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | OmniPath | Yes | ||||
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | Yes | |||
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | Yes | |||
| adhesion | adhesion | HGNC | Yes | Yes | Yes | ||
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | Yes |
Regulatory Interaction Network (14)
14 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NLGNX | Q8N0W4 | NRX1B | P58400 | Yes | Yes | CellPhoneDBSIGNORconnectomeDB2020 | SIGNOR:18923512connectomeDB2020:20543817 | |
| NRX1B | P58400 | NLGN2 | Q8NFZ4 | Yes | Yes | CellChatDBCellPhoneDBSIGNORHPRDBaccin2019Ramilowski2015_Baccin2019Wang | HPRD:8576240SIGNOR:22626542SIGNOR:22626543 | |
| NLGN2 | Q8NFZ4 | NRX1B | P58400 | Yes | Yes | iTALKSIGNORHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerEMBRACECellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb | LRdb:8576240connectomeDB2020:8576240SIGNOR:18923512Baccin2019:85762408576240HPRD:8576240Cellinker:8576240CellTalkDB:8576240 | |
| APBA2 | Q99767 | NRX1B | P58400 | Yes | Yes | HPRDSIGNOR | SIGNOR:11036064HPRD:11036064 | |
| KHDR1 | Q07666 | NRX1B | P58400 | Yes | Yes | SIGNOR | SIGNOR:22196734 | |
| NLGN3 | Q9NZ94 | NRX1B | P58400 | Yes | Yes | CellTalkDBFantom5_LRdbHPMR_LRdbHPRD_LRdbiTALKCellPhoneDBHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020HPRDHPRD_talklrCellinkerWangLRdbSTRING_talklrHPMR_talklr | HPRD:9325340LRdb:8576240connectomeDB2020:8576240LRdb:933SIGNOR:18923512HPRD:8576240Cellinker:8576240connectomeDB2020:9325340CellTalkDB:8576240Cellinker:9325340 | |
| NRX1B | P58400 | DAG1 | Q14118 | Yes | Yes | CellPhoneDBCellChatDBSIGNOR | SIGNOR:22626542CellChatDB:21628410 | |
| COMPLEX:O60941_P11532_P24043_P29475_P56539_Q13326_Q13424_Q13425_Q13884_Q14118_Q16585_Q16586_Q92629_Q9NSN8_Q9NY99_Q9Y4J8 | NRX1B | P58400 | Yes | Yes | SIGNOR | SIGNOR:11470830 | ||
| NLGNY | Q8NFZ3 | NRX1B | P58400 | Yes | Yes | CellPhoneDBSIGNOR | SIGNOR:18923512 | |
| NXPH1 | P58417 | NRX1B | P58400 | Yes | Yes | iTALKSIGNORHPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerEMBRACEFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020LRdb | LRdb:8699246HPRD:8699246HPMR:9856994connectomeDB2020:9856994LRdb:9856994Baccin2019:8699246Cellinker:9856994SIGNOR:9856994HPRD:9856994connectomeDB2020:8699246Cellinker:8699246Baccin2019:9856994 |
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Protein Complex Composition (8)
8 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Glu-NRXN1_CBLN1 | CBLN1NRXN1 | P23435Q9ULB1 | 0:0 | CellChatDB | ||
| NRXN1_CBLN1_complex | CBLN1NRXN1 | P23435P58400 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:NRXN1_CBLN1_complex | |
| CARHSP1GALMGLOD4LACTB2NRXN1NT5C3ANT5DC1PGPPLD3 | A6NDG6P58400Q53H82Q5TFE4Q8IV08Q96C23Q9H0P0Q9HC38Q9Y2V2 | 0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| CARHSP1GALMGLOD4LACTB2NRXN1NT5C3ANT5DC1PGPPLD3 | A6NDG6Q53H82Q5TFE4Q8IV08Q96C23Q9H0P0Q9HC38Q9ULB1Q9Y2V2 | 0:0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| CASKNRXN1 | O14936Q9ULB1 | 3:3 | PDB | PDB:6nid | ||
| LRRTM2NRXN1 | O43300P58400 | 4:4 | PDB | PDB:5z8y | ||
| CARHSP1GLOD4NRXN1 | P58400Q9HC38Q9Y2V2 | 0:0:0 | hu.MAP | |||
| CARHSP1GLOD4NRXN1 | Q9HC38Q9ULB1Q9Y2V2 | 0:0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryWestern blotting | 1 | 38716512 |
Sequence, Structure & Domains
Sequences
Length
472
Mass
50,424
Sequence
MYQRMLRCGAELGSPGGGGGGGGGGGAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIHHFHGSSKHHSVPIAIYRSPASLRGGHAGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV
Alternative Products
Event=Alternative promoter usage, Alternative splicing; Named isoforms=7; Comment=A number of isoforms are produced by alternative promoter usage including the alpha-type and beta-type isoforms which differ in their N-terminus. Additional isoforms may be produced by alternative splicing.; Name=1b; IsoId=P58400-2; Sequence=Displayed; Name=3b; IsoId=P58400-1; Sequence=VSP_059057; Name=1a; IsoId=Q9ULB1-1; Sequence=External; Name=2a; IsoId=Q9ULB1-2; Sequence=External; Name=3a; IsoId=Q9ULB1-3; Sequence=External; Name=4; IsoId=Q9ULB1-4; Sequence=External; Name=5; IsoId=Q9ULB1-5; Sequence=External
Alternative Sequence
205..234; Missing (in isoform 3b)
3D Structural Models
Turn
252..255; 277..279
Helix
272..276
Beta Strand
91..103; 112..123; 126..135; 142..148; 151..160; 163..166; 174..176; 178..185; 188..196; 199..201; 244..250; 260..267; 283..290
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
91..289; Laminin G-like
Region
205..234; Essential for interaction with CBLN1; modulates interaction affinity with NLGN1, NLGN2 and NLGN3; prevents interaction with DAG1/alpha-dystroglycan; modulates interaction with alpha-latrotoxin; 353..385; Disordered; 439..472; Disordered
Protein Families
Neurexin family
Sequence Similarities
Belongs to the neurexin family.
Clinical Relevance
Supporting Publications11
| PMID | Title | Related sentences |
|---|---|---|
| 24505114 | Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform. | These included proteins of known association with cancer exosomes such as MFG-E8, integrins, and MET, and also those less widely reported as exosomally associated, such as ROR1 and ITIH4. |
| 30451371 | Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance. | No related sentences available |
| 31588238 | Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment. | No related sentences available |
| 32295833 | Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. | Notably, mTau exosomes (not control exosomes) contain ANP32A (also known as I1PP2A), an endogenous inhibitor of the PP2A phosphatase which regulates the phosphorylation state of p-Tau. |
| 32468033 | Quantitative proteomic characterization of microvesicles/exosomes from the cerebrospinal fluid of patients with acute bilirubin encephalopathy. | No related sentences available |
| 34401050 | TPI1-reduced extracellular vesicles mediated by Rab20 downregulation promotes aerobic glycolysis to drive hepatocarcinogenesis. | No related sentences available |
| 36635400 | Proteomic profiling of urinary small extracellular vesicles in children with pneumonia: a pilot study. | No related sentences available |
| 38136601 | Identification of Central Nervous System Oncologic Disease Biomarkers in EVs from Cerebrospinal Fluid (CSF) of Pediatric Patients: A Pilot Neuro-Proteomic Study. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 39949490 | CRISPR-dCas9 Activation of TSG-6 in MSCs Modulates the Cargo of MSC-Derived Extracellular Vesicles and Attenuates Inflammatory Responses in Human Intervertebral Disc Cells In Vitro. | No related sentences available |
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