Protein detail

MTPN

Myotrophin (Protein V-1)

Entry name MTPN	UniProt ID P58546	EVMP confidence score 0.38
Supporting publications (n) 5	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Myotrophin (Protein V-1)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000105887

Entrez Gene Symbol

MTPN

Gene Synonym (3)

GCDPMYOTROPHINV-1

Gene Description

Myotrophin

Chromosome

Position

135926760-135977359

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Cell SpecificCorticotrophsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (6)

Molecular Function

GO:0043565 sequence-specific DNA binding

Biological Process (3)

Mediation Categories (3)

Fusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence14

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (8)

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster274	CYB5A CYB5B FADS2 MTPN	O43169 O95864 P00167 P58546	1:1:1:1	Compleat	Compleat:HC2852	22036573
	CPSF7 MTPN NUDT21 P3H1	O43809 P58546 Q32P28 Q8N684	0:0:0:0	hu.MAP
	ACP1 MTPN PGLS PUDP	O95336 P24666 P58546 Q08623	0:0:0:0	hu.MAP2
	CAPZB GABARAPL2 MTPN UBC	P0CG48 P47756 P58546 P60520	1:1:1:1	CompleatCFinder	Compleat:HC7411
	CSTF1 CSTF2 CSTF2T CSTF3 INTS6L MTPN	P33240 P58546 Q05048 Q12996 Q5JSJ4 Q9H0L4	0:0:0:0:0:0	hu.MAP2
	MTPN	P58546	2	PDB	PDB:7df7
	MTPN NPLOC4 UFD1	P58546 Q8TAT6 Q92890	0:0:0	Havugimana2012	Havugimana2012:C_149
	BAG1 MTPN	P58546 Q99933	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
PRotein Organic Solvent Precipitation；Differential Ultracentrifugation	Mass spectrometry	1	32384937

Sequence, Structure & Domains9

Sequences

Length

118

Mass

12,895

Sequence

MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ

3D Structural Models

Turn

56..58

Helix

3..11; 15..23; 38..44; 48..55; 71..78; 81..89; 104..107; 111..117

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Repeat

2..30; ANK 1; 34..66; ANK 2; 67..99; ANK 3

Protein Families

Myotrophin family

Sequence Similarities

Belongs to the myotrophin family.

Clinical Relevance4

Antibody

HPA019735

Interaction Protein

ENSG00000077549

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications5

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available
28986585	Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.	No abstract available
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.
30950185	Unique Protein Profiles of Extracellular Vesicles as Diagnostic Biomarkers for Early and Advanced Non-Small Cell Lung Cancer.	No abstract available
34980157	Proteomic analysis of extracellular vesicles secreted by primary human epithelial endometrial cells reveals key proteins related to embryo implantation.	No abstract available