Protein detail

MTPN

Myotrophin (Protein V-1)

Entry name MTPN	UniProt ID P58546	EVMP score 0.38
Frequency 5	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Myotrophin (Protein V-1)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000105887

Entrez Gene Symbol

MTPN

Gene Synonym

GCDPMYOTROPHINV-1

Gene Description

Myotrophin

Chromosome

Position

135926760-135977359

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificCorticotrophsSingle-Nuclei Brain Specificendothelial cell

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

GO:0043565 sequence-specific DNA binding

Biological Process

Mediation Categories

Fusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster274	CYB5A CYB5B FADS2 MTPN	O43169 O95864 P00167 P58546	1:1:1:1	Compleat	Compleat:HC2852	22036573
	CPSF7 MTPN NUDT21 P3H1	O43809 P58546 Q32P28 Q8N684	0:0:0:0	hu.MAP
	ACP1 MTPN PGLS PUDP	O95336 P24666 P58546 Q08623	0:0:0:0	hu.MAP2
	CAPZB GABARAPL2 MTPN UBC	P0CG48 P47756 P58546 P60520	1:1:1:1	CompleatCFinder	Compleat:HC7411
	CSTF1 CSTF2 CSTF2T CSTF3 INTS6L MTPN	P33240 P58546 Q05048 Q12996 Q5JSJ4 Q9H0L4	0:0:0:0:0:0	hu.MAP2
	MTPN	P58546	2	PDB	PDB:7df7
	MTPN NPLOC4 UFD1	P58546 Q8TAT6 Q92890	0:0:0	Havugimana2012	Havugimana2012:C_149
	BAG1 MTPN	P58546 Q99933	0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
PRotein Organic Solvent Precipitation；Differential Ultracentrifugation	Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

118

Mass

12,895

Sequence

MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTAFEATDNQAIKALLQ

3D Structural Models

Turn

56..58

Helix

3..11; 15..23; 38..44; 48..55; 71..78; 81..89; 104..107; 111..117

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Repeat

2..30; ANK 1; 34..66; ANK 2; 67..99; ANK 3

Protein Families

Myotrophin family

Sequence Similarities

Belongs to the myotrophin family.

Clinical Relevance

Antibody

HPA019735

Interaction Protein

ENSG00000077549

Interaction Count

Interaction Dataset

biogrid_opencell