Protein detail
SNP25
Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein)
Entry name SNP25 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein)
Protein Class
Disease related genesFDA approved drug targetsHuman disease related genesPredicted intracellular proteinsTransporters
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Biotech drugs
Ensembl
Entrez Gene Symbol
Gene Synonym
bA416N4.2dJ1068F16.2RIC-4RIC4SEC9SNAPSNAP-25
Gene Description
Synaptosome associated protein 25
Chromosome
20
Position
10172395-10308258
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificMyonucleiSingle-Nuclei Brain Specificfibroblast
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component
- GO:0001917 photoreceptor inner segment
- GO:0005737 cytoplasm
- GO:0005768 endosome
- GO:0005802 trans-Golgi network
- GO:0005829 cytosol
- GO:0005856 cytoskeleton
- GO:0005886 plasma membrane
- GO:0005938 cell cortex
- GO:0008021 synaptic vesicle
- GO:0008076 voltage-gated potassium channel complex
- GO:0015629 actin cytoskeleton
- GO:0016020 membrane
- GO:0030027 lamellipodium
- GO:0030175 filopodium
- GO:0030426 growth cone
- GO:0031083 BLOC-1 complex
- GO:0031201 SNARE complex
- GO:0031982 vesicle
- GO:0035579 specific granule membrane
- GO:0042734 presynaptic membrane
- GO:0043005 neuron projection
- GO:0043025 neuronal cell body
- GO:0044295 axonal growth cone
- GO:0048471 perinuclear region of cytoplasm
- GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
- GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
- GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex
- GO:0070821 tertiary granule membrane
- GO:0097470 ribbon synapse
- GO:0098888 extrinsic component of presynaptic membrane
- GO:0098978 glutamatergic synapse
Molecular Function
- GO:0005249 voltage-gated potassium channel activity
- GO:0005484 SNAP receptor activity
- GO:0005515 protein binding
- GO:0008289 lipid binding
- GO:0017022 myosin binding
- GO:0017075 syntaxin-1 binding
- GO:0019904 protein domain specific binding
- GO:0044325 transmembrane transporter binding
- GO:0048306 calcium-dependent protein binding
Biological Process
Reactome
- R-hsa-264642 acetylcholine neurotransmitter release cycle
- R-hsa-9824439 bacterial infection pathways
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-212676 dopamine neurotransmitter release cycle
- R-hsa-888590 gaba synthesis release reuptake and degradation
- R-hsa-210500 glutamate neurotransmitter release cycle
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-163685 integration of energy metabolism
- R-hsa-112316 neuronal system
- R-hsa-168799 neurotoxicity of clostridium toxins
- R-hsa-112310 neurotransmitter release cycle
- R-hsa-6798695 neutrophil degranulation
- R-hsa-181430 norepinephrine neurotransmitter release cycle
- R-hsa-449836 other interleukin signaling
- R-hsa-422356 regulation of insulin secretion
- R-hsa-9709957 sensory perception
- R-hsa-9659379 sensory processing of sound
- R-hsa-181429 serotonin neurotransmitter release cycle
- R-hsa-449147 signaling by interleukins
- R-hsa-112315 transmission across chemical synapses
- R-hsa-5339562 uptake and actions of bacterial toxins
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SNAP25 | PRKCA | P17252 | T | 138 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:12459461KEA:12459461SIGNOR:12459461ProtMapper:12459461 |
| SNAP25 | PRKCA | P17252 | S | 187 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | KEA:15277518KEA:12459461ProtMapper:12459461ProtMapper:18171919HPRD:12459461SIGNOR:12459461SIGNOR:18171919 |
| SNAP25 | PRKACA | P17612 | T | 138 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSite | HPRD:12459461KEA:12459461SIGNOR:12459461ProtMapper:12459461 |
| SNAP25 | PRKACA | P17612 | T | 29 | phosphorylation | PhosphoSite | |
| SNAP25 | PRKACA | P17612 | S | 187 | phosphorylation | PhosphoSite | |
| SNAP25 | PRKACA | P17612 | S | 28 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
7 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SYT1 | P21579 | SNP25 | P60880 | Yes | Yes | No | SIGNORHPRDCui2007HINTBioGRIDWang | BioGRID:12062043HINT:10692432SIGNOR:16679567HINT:26030874BioGRID:10692432HINT:30610939HPRD:10692432HINT:12062043 |
| SNAPN | O95295 | SNP25 | P60880 | Yes | Yes | Yes | SIGNORHPRDCui2007HINTWang | HINT:22890573SIGNOR:18167355HINT:10195194HPRD:10195194 |
| CAPS2 | Q86UW7 | SNP25 | P60880 | Yes | Yes | No | SIGNOR | SIGNOR:24363652 |
| KPCA | P17252 | SNP25 | P60880 | Yes | Yes | Yes | WangPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDCui2007PhosphoSite_KEAKEAKinexus_KEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | KEA:15277518KEA:12459461ProtMapper:12459461ProtMapper:18171919HPRD:12459461HPRD-phos:12459461PhosphoSite:17325194PhosphoSite:22311984SIGNOR:12459461SIGNOR:18171919 |
| CAPS1 | Q9ULU8 | SNP25 | P60880 | Yes | Yes | No | SIGNOR | SIGNOR:24363652 |
| KAPCA | P17612 | SNP25 | P60880 | Yes | No | No | PhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteHPRD-phosPhosphoSite_ProtMapper | KEA:12459461ProtMapper:12459461PhosphoSite:18171919HPRD:12459461HPRD-phos:12459461SIGNOR:12459461 |
| NSF | P46459 | SNP25 | P60880 | Yes | No | Yes | SIGNOR | SIGNOR:16679567 |
Protein Complex Composition
15 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| SNARE complex (HGSSNAP25STX13) | HGSSNAP25STX12 | O14964P60880Q86Y82 | 1:1:1 | CompleatCORUM | CORUM:706Compleat:HC1780 | 14769786 |
| SNARE complex (SNAP25VAMP3VAMP2NAPBSTX13) | NAPBSNAP25STX12VAMP2VAMP3 | P60880P63027Q15836Q86Y82Q9H115 | 1:1:1:1:1 | CompleatCORUM | Compleat:HC3498CORUM:1874 | 9817754 |
| SNARE complex (VAMP2SNAP25STX13) | SNAP25STX12VAMP2 | P60880P63027Q86Y82 | 1:1:1 | CompleatCORUM | CORUM:707Compleat:HC1840 | 14769786 |
| SNARE complex (VAMP2SNAP25STX1aCPLX1) | CPLX1SNAP25STX1AVAMP2 | O14810P60880P63027Q16623 | 1:1:1:1 | CORUMCompleatCFinder | Compleat:HC1741CORUM:793 | 7553862 |
| SNARE complex (VAMP2SNAP25STX1aCPLX1CPLX3) | CPLX1CPLX3SNAP25STX1AVAMP2 | O14810P60880P63027Q16623Q8WVH0 | 1:1:1:1:1 | CompleatCORUM | CORUM:1137Compleat:HC1771 | 15911881 |
| SNARE complex (VAMP2SNAP25STX1aCPLX2) | CPLX2SNAP25STX1AVAMP2 | P60880P63027Q16623Q6PUV4 | 1:1:1:1 | CompleatCORUM | Compleat:HC558CORUM:794 | 7553862 |
| SNARE complex (VAMP2SNAP25STX1aCPLX3CPLX4) | CPLX3CPLX4SNAP25STX1AVAMP2 | P60880P63027Q16623Q7Z7G2Q8WVH0 | 1:1:1:1:1 | CompleatCORUM | Compleat:HC154CORUM:1138 | 15911881 |
| SNARE complex (VAMP2SNAP25STX1aSTX3CPLX1CPLX3CPLX4) | CPLX1CPLX3CPLX4SNAP25STX1ASTX3VAMP2 | O14810P60880P63027Q13277Q16623Q7Z7G2Q8WVH0 | 1:1:1:1:1:1:1 | CompleatCORUM | Compleat:HC2346CORUM:1139 | 15911881 |
| SNARE complex STX1A-SNAP25-VAMP1 | SNAP25STX1AVAMP1 | P23763P60880Q16623 | 1:1:1 | ComplexPortal | 2913915926635000147552923784858920798282 | |
| SNARE complex STX1B-SNAP25-VAMP1 | SNAP25STX1BVAMP1 | P23763P60880P61266 | 1:1:1 | ComplexPortal | 2913915926635000147552923784858920798282 |
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Isolation & Detection Technology
0 records.
Sequence, Structure & Domains
Sequences
Length
206
Mass
23,315
Sequence
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Comment=Isoforms differ by the usage of two alternative homologous exons (5a and 5b) which code for positions 56 to 94 and differ only in 9 positions out of 39.; Name=1; Synonyms=SNAP-25b; IsoId=P60880-1, P13795-1; Sequence=Displayed; Name=2; Synonyms=SNAP-25a; IsoId=P60880-2, P13795-2; Sequence=VSP_006186
Alternative Sequence
58..89; ERIEEGMDQINKDMKEAEKNLTDLGKFCGLCV -> DRVEEGMNHINQDMKEAEKNLKDLGKCCGLFI (in isoform 2)
3D Structural Models
Helix
8..80; 148..167
Beta Strand
191..193
3D Structure
NMR spectroscopy (1); X-ray crystallography (13)
Domain & Motif Annotations
Compositional Bias
1..20; Basic and acidic residues
Domain (FT)
19..81; t-SNARE coiled-coil homology 1; 140..202; t-SNARE coiled-coil homology 2
Region
1..75; Interaction with CENPF; 1..23; Disordered; 111..120; Interaction with ZDHHC17
Protein Families
SNAP-25 family
Sequence Similarities
Belongs to the SNAP-25 family.
Clinical Relevance
Disease Involvement
Congenital myasthenic syndromeDisease variantFDA approved drug targetsIntellectual disability
Related Diseases
Biomarker
Approved
Drug Targets
FDA approved drug targets
Drugs
Interaction Protein
ENSG00000106089ENSG00000135604ENSG00000205726
Interaction Count
3
Interaction Dataset
intact_biogrid