Protein detail
CXCR4
C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
Protein symbol CXCR4 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 7 | Protein classification |
Basic Information
Protein Names
C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
Protein Function
- Transporters
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes:Candidate cancer biomarkers
- G-protein coupled receptors:GPCRs excl olfactory receptors
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
39..63; Helical; Name=1; 78..99; Helical; Name=2; 111..130; Helical; Name=3; 155..174; Helical; Name=4; 196..216; Helical; Name=5; 242..261; Helical; Name=6; 283..302; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificGonadotrophsSecretome LocationIntracellular and membraneSecretome FunctionEnzyme
Function & Pathway
Protein Function
- Transporters
- CD markers
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes:Candidate cancer biomarkers
- G-protein coupled receptors:GPCRs excl olfactory receptors
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0005737 cytoplasm
- GO:0005764 lysosome
- GO:0005769 early endosome
- GO:0005770 late endosome
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0009986 cell surface
- GO:0031252 cell leading edge
- GO:0031410 cytoplasmic vesicle
- GO:0032991 protein-containing complex
- GO:0070062 extracellular exosome
- GO:0070161 anchoring junction
Molecular Function
- GO:0001618 virus receptor activity
- GO:0003779 actin binding
- GO:0004930 G protein-coupled receptor activity
- GO:0005515 protein binding
- GO:0015026 coreceptor activity
- GO:0016493 C-C chemokine receptor activity
- GO:0016494 C-X-C chemokine receptor activity
- GO:0019957 C-C chemokine binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0032027 myosin light chain binding
- GO:0036094 small molecule binding
- GO:0038147 C-X-C motif chemokine 12 receptor activity
- GO:0043130 ubiquitin binding
Biological Process
KEGG
- hsa03250 Viral life cycle - HIV-1
- KEGG:hsa03260 Virion - Human immunodeficiency virus
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04061 Viral protein interaction with cytokine and cytokine receptor
- KEGG:hsa04062 Chemokine signaling pathway
- KEGG:hsa04144 Endocytosis
- KEGG:hsa04360 Axon guidance
- KEGG:hsa04670 Leukocyte transendothelial migration
- KEGG:hsa04672 Intestinal immune network for IgA production
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05200 Pathways in cancer
Reactome
- R-hsa-380108 chemokine receptors bind chemokines
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-9734767 developmental cell lineages
- R-hsa-9820448 developmental cell lineages of the exocrine pancreas
- R-hsa-9937080 developmental lineage of multipotent pancreatic progenitor cells
- R-hsa-162594 early phase of hiv life cycle
- R-hsa-9823730 formation of definitive endoderm
- R-hsa-9758941 gastrulation
- R-hsa-500792 gpcr ligand binding
- R-hsa-418594 g alpha i signalling events
- R-hsa-162906 hiv infection
- R-hsa-162587 hiv life cycle
- R-hsa-5663205 infectious disease
- R-hsa-9675108 nervous system development
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-1474165 reproduction
- R-hsa-372790 signaling by gpcr
- R-hsa-376176 signaling by robo receptors
- R-hsa-9827857 specification of primordial germ cells
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
26 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CXCR4 | GRK6 | P43250 | S | 324 | phosphorylation | Sparser_ProtMapperProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:20048153ProtMapper:28328745dbPTM:19116316 |
| CXCR4 | GRK6 | P43250 | S | 325 | phosphorylation | dbPTMPhosphoSitePhosphoSite_ProtMapperProtMapper | dbPTM:19116316dbPTM:20048153 |
| CXCR4 | GRK6 | P43250 | S | 330 | phosphorylation | dbPTMPhosphoSite | dbPTM:20048153 |
| CXCR4 | GRK6 | P43250 | S | 339 | phosphorylation | RLIMS-P_ProtMapperdbPTMPhosphoSiteProtMapper | ProtMapper:20048153dbPTM:20048153 |
| CXCR4 | GRK6 | P43250 | S | 328 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CXCR4 | GRK6 | P43250 | S | 329 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CXCR4 | PRKCD | Q05655 | S | 324 | phosphorylation | SIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:28449947SIGNOR:10521508 |
| CXCR4 | PRKCD | Q05655 | S | 338 | phosphorylation | SIGNOR | SIGNOR:10521508 |
| CXCR4 | PRKCD | Q05655 | S | 339 | phosphorylation | SIGNOR | SIGNOR:10521508 |
| CXCR4 | PRKCD | Q05655 | S | 325 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
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Ligand-Receptor Signaling
72 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | Kirouac2010 | No | Yes | No | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | Yes | No |
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Regulatory Interaction Network
14 records.
Page 1 of 2Next
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ADRA1A-CXCR4 complex | ADRA1ACXCR4 | P35348P61073 | 0:0 | CORUM | CORUM:6807 | 25775528 |
| ADRB1-CXCR4 complex | ADRB1CXCR4 | P08588P61073 | 0:0 | CORUM | CORUM:6808 | 25775528 |
| CD74_CXCR4 | CD74CXCR4 | P04233P61073 | 0:0 | CellinkerCellChatDB | ||
| CXCR4JAK2STAT1STAT2STAT3 | O60674P40763P42224P52630P61073 | 1:1:1:1:1 | CompleatCFinder | Compleat:HC7610 | ||
| CXCL12CXCR4 | P48061P61073 | 2:2 | PDB | PDB:2n55PDB:2k05PDB:2k03PDB:2k04 | ||
| CXCR4 | P61073 | 2 | PDB | PDB:3oe8PDB:8yu7PDB:3oduPDB:3oe9PDB:8u4t |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 23161513 |
Sequence, Structure & Domains
Sequences
Length
352
Mass
39,746
Sequence
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
Alternative Products
Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; IsoId=P61073-1, P30991-1; Sequence=Displayed; Name=2; Synonyms=CXCR4-LO; IsoId=P61073-2, P30991-2; Sequence=VSP_001890
Alternative Sequence
1..5; MEGIS -> MSIPLPLLQ (in isoform 2)
3D Structural Models
Turn
34..36; 63..66; 140..142; 267..269; 302..306
Helix
37..62; 72..88; 91..99; 105..139; 145..153; 155..159; 161..166; 169..174; 193..207; 209..225; 226..228; 231..266; 274..291; 294..301; 313..317
Beta Strand
9..11; 21..23; 67..69; 175..179; 181..188
3D Structure
Electron microscopy (20); NMR spectroscopy (4); X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
337..352; Low complexity
Motif
133..135; Important for signaling; 344..347; P-X-P-P motif
Domain (CC)
The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity.; DOMAIN: The P-X-P-P motif is phosphorylated in response to ligand binding, promoting. association with beta-arrestin ARRB1..
Region
1..21; Important for chemokine binding, signaling and HIV-1 coreceptor activity; 94..97; Chemokine binding; 113..117; Chemokine binding; 135..147; Involved in dimerization; when bound to chemokine; 186..190; Chemokine binding, important for signaling and HIV-1 coreceptor activity; 191..210; Involved in dimerization; 266..268; Involved in dimerization; 329..352; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Related Diseases
Acute myeloid leukaemiaBreast cancerChronic arterial occlusive diseaseDiabetes mellitusHuman immunodeficiency virus diseaseInnate/adaptive immunodeficiencyKaposi sarcomaMalignant haematopoietic neoplasmMature B-cell leukaemiaMature B-cell lymphomaMelanomaMetastatic tumourMultiple myelomaMyelodysplastic syndromeNeuroendocrine carcinomaNeutropeniaPancreatic cancerPsoriasisRenal cell carcinomaRespiratory infectionRetinopathySarcomaSolid tumour/cancerTransplanted organ/tissue
Biomarker
Phase 2; Phase 3; Investigative; Preclinical; Approved; Phase 1; Phase 1/2; Discontinued in Phase 1
Drugs
CISPLATINULOCUPLUMABRECOMBINANT RANTESMSX-122CXCR4 ANTAGONIST USL311MOTIXAFORTIDELY-2624587CHEMBL:CHEMBL2062277MAVORIXAFORNULLPLERIXAFORBEVACIZUMAB-AWWBCTCE-9908BURIXAFORBALIXAFORTIDECHEMBL:CHEMBL2347630CTCE-0214CHEMBL:CHEMBL2347631CHEMBL:CHEMBL2347632CHEMBL:CHEMBL1221944GMI-1359CHEMBL:CHEMBL1242210RECOMBINANT CHEMOKINECHEMBL:CHEMBL2347633PF-06747143