Protein detail
B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
Entry name B2MG | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted secreted proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
Protein Class (7)
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted secreted proteinsTransporters
Protein Function (10)
- Cancer-related genes:Mutational cancer driver genes
- Transporters
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Cancer-related genes:Mutated cancer genes
- Potential drug targets
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Predicted secreted proteins
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Description
Beta-2-microglobulin
Chromosome
15
Position
44711358-44718851
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificEsophageal apical cellsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell Specificintermediate monocyte
Function & Pathway
Protein Function (10)
- Cancer-related genes:Mutational cancer driver genes
- Transporters
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Cancer-related genes:Mutated cancer genes
- Potential drug targets
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
- Predicted secreted proteins
- Disease related genes
Cellular Component (25)
- GO:0000139 Golgi membrane
- GO:0005576 extracellular region
- GO:0005615 extracellular space
- GO:0005765 lysosomal membrane
- GO:0005783 endoplasmic reticulum
- GO:0005788 endoplasmic reticulum lumen
- GO:0005794 Golgi apparatus
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
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Molecular Function (6)
Biological Process (3)
KEGG (6)
Reactome (28)
- R-hsa-1280218 adaptive immune system
- R-hsa-977225 amyloid fiber formation
- R-hsa-983170 antigen presentation folding assembly and peptide loading of class i mhc
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-9824439 bacterial infection pathways
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-2172127 dap12 interactions
- R-hsa-2424491 dap12 signaling
- R-hsa-1236977 endosomal vacuolar pathway
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Mediation Categories (5)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence108
Ligand-Receptor Signaling (17)
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | CellPhoneDB | Yes | ||||
| transmembrane | transmembrane | OmniPath | Yes | ||||
| secreted | secreted | UniProt_keyword | Yes | ||||
| secreted | secreted | UniProt_location | Yes | ||||
| secreted | secreted | connectomeDB2020 | Yes | ||||
| secreted | secreted | Cellinker | Yes | ||||
| secreted | secreted | OmniPath | Yes |
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Protein Complex Composition (90)
90 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| B2MD2KZ37 | D2KZ37P61769 | 1:1 | PDB | PDB:8esh | ||
| B2MD5H3J5 | D5H3J5P61769 | 1:1 | PDB | PDB:7tud | ||
| B2MD5H3J5Q9TQB0 | D5H3J5P61769Q9TQB0 | 1:1:1 | PDB | PDB:7tuc | ||
| B2MD9J307 | D9J307P61769 | 1:1 | PDB | PDB:6uzpPDB:6uzsPDB:6uzq | ||
| B2MD9UAY1WT1 | D9UAY1P19544P61769 | 2:2:2 | PDB | PDB:8isn | ||
| B2MF4NBQ1 | F4NBQ1P61769 | 1:1 | PDB | PDB:6vb3 | ||
| B2MF4NBQ8 | F4NBQ8P61769 | 1:1 | PDB | PDB:6viuPDB:6vb6PDB:6uzoPDB:6vb7PDB:6vb5PDB:6vb4PDB:6uznPDB:6vb1PDB:6vb0PDB:6uzm | ||
| B2MF4NBT2 | F4NBT2P61769 | 4:4 | PDB | PDB:8emgPDB:8emjPDB:8v4zPDB:8eo8PDB:8enhPDB:8emi | ||
| B2MF4NC28LMNA | F4NC28P02545P61769 | 1:1:1 | PDB | PDB:7wzz | ||
| B2MF6IQM2 | F6IQM2P61769 | 2:2 | PDB | PDB:8shi |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass Spectrometry | 1 | 38037300 |
Sequence, Structure & Domains
Sequences
Length
119
Mass
13,715
Sequence
MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
3D Structural Models
Turn
93..95; 117..119
Helix
35..37
Beta Strand
21..23; 26..33; 41..53; 56..61; 64..66; 67..69; 71..78; 79..82; 83..88; 98..103; 107..109; 111..114
3D Structure
Electron microscopy (29); NMR spectroscopy (6); X-ray crystallography (1222)
Domain & Motif Annotations
Domain (FT)
25..113; Ig-like C1-type
Protein Families
Beta-2-microglobulin family
Sequence Similarities
Belongs to the beta-2-microglobulin family.
Clinical Relevance
Disease Involvement (3)
AmyloidosisCancer-related genesDisease variant
Related Diseases
Drug Targets
Literature-reported target
Interaction Protein (4)
ENSG00000010704ENSG00000104870ENSG00000206503ENSG00000234745
Interaction Count
4
Interaction Dataset (2)
intact_biogridintact_biogrid_bioplex
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37713494 | ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids. | No related sentences available |