EV MemProt Atlas

Basic Information11

Protein Names

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)

Protein Class (4)

EnzymesEssential proteinsPlasma proteinsPredicted intracellular proteins

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Ensembl

ENSG00000172531

Entrez Gene Symbol

PPP1CA

Gene Synonym (4)

PP-1APP1APP1alphaPPP1A

Gene Description

Protein phosphatase 1 catalytic subunit alpha

Chromosome

11

Position

67398181-67421183

Supporting publications (n)

26

EVMP confidence score

0.75

Fluorescence & Localization6

Tissue SpecificcervixCell SpecificAdrenal cortex cellsBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted - unknown locationSecretome FunctionEnzyme

Function & Pathway8

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Cellular Component (15)

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Molecular Function (10)

Biological Process (3)

KEGG (23)

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Reactome (21)

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Canonical Pathways

M200 Pid era genomic pathway

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence133

Enzyme-Mediated Modification (27)

27 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
PPP1CA	CDK3	Q00526	T	331	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CA	CDK10	Q15131	T	331	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CA	CDK4	P11802	T	331	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CA	CDK6	Q00534	T	331	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CA	CDK7	P50613	T	331	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CA	CDK8	P49336	T	331	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CA	CDK11B	P21127	T	331	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CA	CDK19	Q9BWU1	T	331	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CA	CDK9	P50750	T	331	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CA	CDK13	Q14004	T	331	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

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Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (44)

44 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PP1R8	Q12972	PP1A	P62136	Yes	No	Yes	LMPIDSIGNORHPRDHINTHuRIIntActDIPSPIKE_LCLit-BM-17	Lit-BM-17:12788942 IntAct:22940584 IntAct:32296183 SPIKE_LC:15231748 HINT:25593058 HINT:22940584 SPIKE_LC:16189514 IntAct:22365833 IntAct:18842582 Lit-BM-17:15231748 LMPID:9353294 HINT:10637318 HINT:12788942 Lit-BM-17:27173435 DIP:22940584 Lit-BM-17:26186194 HINT:18842582 Lit-BM-17:18842582 Lit-BM-17:20516061 Lit-BM-17:28330616 HINT:33961781 LMPID:20044954 Lit-BM-17:10637318 Lit-BM-17:20671031 Lit-BM-17:22365833 SIGNOR:1322907 HINT:28330616 HPRD:15231748 LMPID:12657641 IntAct:15231748
SHOC2	Q9UQ13	PP1A	P62136	Yes	Yes	No	HINTSIGNOR	HINT:35831509 HINT:35830882 HINT:36175670 SIGNOR:16630891 HINT:33961781
PP1A	P62136	STAT3	P40763	Yes	No	Yes	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:19440292 SIGNOR:19440292
PP1A	P62136	RAF1	P04049	Yes	Yes	No	SIGNOR_ProtMapperSIGNORProtMapperDEPOD	ProtMapper:16630891 SIGNOR:16630891 DEPOD:7604263
CDK1	P06493	PP1A	P62136	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAKinexus_KEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperLit-BM-17PhosphoSite_ProtMapperSPIKE_LC	phosphoELM:9122166 SPIKE_LC:17145710 KEA:18088087 KEA:97225924 Lit-BM-17:17274640 KEA:12202491 SIGNOR:12202491 KEA:9122166 ProtMapper:12202491 KEA:10880350
PP1A	P62136	IFIH1	Q9BYX4	Yes	Yes	No	InnateDBSIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:23499489 ProtMapper:23499489 InnateDB:23499489
PP1A	P62136	MK01	P28482	Yes	No	Yes	HPRDSIGNOR	SIGNOR:12840032 HPRD:12624094
PP1A	P62136	CCND3	P30281	Yes	Yes	No	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:16331257 SIGNOR:16331257
PP1A	P62136	PROF1	P07737	Yes	Yes	No	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:22479341 ProtMapper:22479341
PP1A	P62136	AURKA	O14965	Yes	No	Yes	HPRDSIGNORDEPOD	SIGNOR:11551964 DEPOD:11039908 HPRD:11551964

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Protein Complex Composition (56)

56 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
SHOC2-MRAS-PPP1CA complex	MRAS PPP1CA SHOC2	O14807 P62136 Q9UQ13	2:2:2	KEGG-MEDICUSComplexPortalPDB	PDB:7upiPDB:7UPIPDB:7TVFintact:EBI-58997210PDB:7tvfPDB:7txhPDB:7TXH	36175670 14755292 35830882 35831509
Sds22p/Glc7p complex	DNAAF1 DRC3 PPP1CA PPP1CB PPP1CC PPP1R7	P36873 P62136 P62140 Q15435 Q8NEP3 Q9H069	1:1:1:1:1:1	Compleat	Compleat:HC1185	10775415
	C2orf74 PPP1CA PPP1R37 ZFYVE16	A8MZ97 O75864 P62136 Q7Z3T8	0:0:0:0	hu.MAP
	C2orf74 HOMEZ PPP1CA PPP1R37	A8MZ97 O75864 P62136 Q8IX15	0:0:0:0	hu.MAP
	C2orf74 PPP1CA PPP1R13L PPP1R37	A8MZ97 O75864 P62136 Q8WUF5	0:0:0:0	hu.MAP
	C2orf74 CSRNP1 PPP1CA PPP1R37	A8MZ97 O75864 P62136 Q96S65	0:0:0:0	hu.MAP
	ADISSP C2orf74 PPP1CA PPP1R37	A8MZ97 O75864 P62136 Q9GZN8	0:0:0:0	hu.MAP
	C2orf74 PLCL2 PPP1CA PPP1R37	A8MZ97 O75864 P62136 Q9UPR0	0:0:0:0	hu.MAP
	BRCA1 CHD1 CSNK2A2 CSNK2B FKBP15 FKBP3 H2AX H3C11 H4C4 KMT2E PPP1CA SSRP1 UHMK1	O14646 P16104 P19784 P38398 P62136 P62805 P67870 P68431 Q00688 Q08945 Q5T1M5 Q8IZD2 Q8TAS1	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7000
	AURKA AURKB CDK1 CENPE HCFC1 KIF11 LMNA NDC80 NUF2 PKMYT1 PPP1CA PPP1CC	O14777 O14965 P02545 P06493 P36873 P51610 P52732 P62136 Q02224 Q96GD4 Q99640 Q9BZD4	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4180

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30379855

Sequence, Structure & Domains12

Sequences

Length

330

Mass

37,512

Sequence

MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P62136-1; Sequence=Displayed; Name=2; IsoId=P62136-2; Sequence=VSP_043377; Name=3; IsoId=P62136-3; Sequence=VSP_046754

Alternative Sequence

18; E -> EGSRVLTPHCAP (in isoform 2); 19..62; Missing (in isoform 3)

3D Structural Models

Turn

23..25; 115..117; 132..135; 166..168; 259..262

Helix

9..18; 19..21; 32..48; 69..79; 100..113; 124..126; 128..131; 136..143; 146..156; 183..187; 200..206; 229..239; 272..274

Beta Strand

51..55; 57..62; 87..89; 94..98; 118..120; 162..165; 169..171; 197..199; 214..218; 222..227; 242..246; 248..251; 254..258; 263..267; 280..285; 290..297

3D Structure

Electron microscopy (2); X-ray crystallography (43)

Domain & Motif Annotations

Region

306..330; Disordered

Protein Families (2)

PPP phosphatase family
PP-1 subfamily

Sequence Similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Clinical Relevance8

Related Diseases

Molluscum contagiosum

Biomarker

Approved

Drug Targets

Successful target

Drugs (5)

OKADAIC ACID CANTHARIDIN MICROCYSTIN-LR CHEMBL:CHEMBL1503729 DEMETHYL-CANTHARIDIN

Antibody (2)

CAB004545 HPA046833

Interaction Protein (57)

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

Interaction Count

57

Interaction Dataset (2)

intact_biogridintact_biogrid_bioplex

Supporting Publications26

PMID	Title	Abstract
26826536	[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].	No abstract available
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
32230970	Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.	No abstract available
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
32916986	Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines.	No abstract available
33304478	The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.	No abstract available
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
34064677	Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells.	No abstract available
34473505	Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.	No abstract available
34576246	Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.	No abstract available

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Entry name PP1A	UniProt ID P62136	EVMP confidence score 0.75
Supporting publications (n) 26	Transmembrane count	Protein classification EnzymesEssential proteinsPlasma proteinsPredicted intracellular proteins