Protein detail

PP1A

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)

Entry name
PP1A
UniProt ID
P62136
EVMP confidence score
0.75
Supporting publications (n)
26
Transmembrane count
Protein classification
EnzymesEssential proteinsPlasma proteinsPredicted intracellular proteins
Basic Information
Protein Names
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Protein Class (4)
EnzymesEssential proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (3)
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Hydrolases
Ensembl
ENSG00000172531
Entrez Gene Symbol
PPP1CA
Gene Synonym (4)
PP-1APP1APP1alphaPPP1A
Gene Description
Protein phosphatase 1 catalytic subunit alpha
Chromosome
11
Position
67398181-67421183
Supporting publications (n)
26
EVMP confidence score
0.75
Fluorescence & Localization
Tissue SpecificcervixCell SpecificAdrenal cortex cellsBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted - unknown locationSecretome FunctionEnzyme
Function & Pathway
Protein Function (3)
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Hydrolases
Cellular Component (15)
Page 1 of 2
Molecular Function (10)
Biological Process (3)
KEGG (23)
Page 1 of 3
Reactome (21)
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Canonical Pathways
M200 Pid era genomic pathway
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence133

Enzyme-Mediated Modification (27)

27 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
PPP1CACDK12Q9NYV4T331phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CACDK16Q00536T331phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CACDK17Q00537T331phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CACDK18Q07002T331phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CACDK20Q8IZL9T331phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CAGSK3BP49841T320phosphorylationKEAKEA:17570479
PPP1CAPRKCAP17252S325phosphorylationKEAKEA:9399575
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Ligand-Receptor Signaling (5)

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Regulatory Interaction Network (44)

44 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PP1AP62136TIF1BQ13263YesYesSPIKESPIKE_LCSIGNORSPIKE:20424263SPIKE_LC:20424263SIGNOR:20424263
PPR1BQ9UD71PP1AP62136YesYesWangNetPathSIGNORHPRDLMPIDSPIKE_LCSPIKELMPID:9108011LMPID:10075680HPRD:9108011SPIKE:11440854SPIKE_LC:11440854LMPID:16428298NetPath:19651774SIGNOR:10604473
SMAD7O15105PP1AP62136YesYesWangSIGNORSignaLink3SignaLink3:16571110SignaLink3:23331499SIGNOR:16571110
PP1AP62136ACVL1P37023YesYesWangSignaLink3SignaLink3:16571110SignaLink3:23331499
LMTK2Q8IWU2PP1AP62136YesYesYesphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperHINTSignaLink3SIGNOR_ProtMapperLit-BM-17PhosphoSitePhosphoSite_ProtMapperSPIKE_LCPhosphoSite:17283141ProtMapper:12393858SignaLink3:12393858Lit-BM-17:12393858PhosphoSite:16785988SIGNOR:12393858PhosphoSite:35081344PhosphoSite:17202132PhosphoSite:12202491HINT:28065597PhosphoSite:18250156SignaLink3:23331499HINT:12393858SPIKE_LC:12393858PhosphoSite:29764992PhosphoSite:24120663
IPP2P41236PP1AP62136YesYesLMPIDSIGNORHPRDHINTIntActDIPLit-BM-17DIP:20826336IntAct:22321011Lit-BM-17:26186194Lit-BM-17:27173435HINT:28330616HINT:10807923HINT:20826336HINT:22321011IntAct:10807923IntAct:20826336SIGNOR:18250156Lit-BM-17:28330616HINT:25593058LMPID:16428298HPRD:10807923Lit-BM-17:22321011Lit-BM-17:10807923HINT:33961781
PP1AP62136AXIN1O15169YesYesSIGNORProtMapperDEPODACSNSIGNOR_ProtMapperHPRD-phosSPIKE_LCHPRD-phos:17318175SIGNOR:17318175ACSN:17318175SPIKE_LC:17318175DEPOD:17318175ProtMapper:17318175
PP1AP62136NOS3P29474YesYesSIGNOR_ProtMapperSIGNORProtMapperDEPODProtMapper:19036824SIGNOR:19036824DEPOD:19036824
PP1AP62136CASP9P55211YesYesSIGNORProtMapperDEPODACSNSIGNOR_ProtMapperProtMapper:16888006SIGNOR:22311969SIGNOR:16888006ACSN:16888006ACSN:12792650ProtMapper:22311969DEPOD:16888006
PP1AP62136PREX1Q8TCU6YesYesSIGNORSIGNOR:22242915
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Protein Complex Composition (56)

56 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CDK1HCFC1HCFC2HSPA4MARK4PKMYT1PPP1CAPRKG1P06493P34932P51610P62136Q13976Q96L34Q99640Q9Y5Z71:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC9506
CDK4HCFC1HSP90AA1HSPA4HSPA8KLHDC10MARK4PPP1CAPPP1CCRIPK3UBCWDR82P07900P0CG48P11142P11802P34932P36873P51610P62136Q6PID8Q6UXN9Q96L34Q9Y5721:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC5084
ASH2LCXXC1H3-4H3C11HCFC1HCFC2HSPA4HSPA8PHF8PPP1CASPOCD1WDR5WDR82P11142P34932P51610P61964P62136P68431Q16695Q6UXN9Q6ZMY3Q9P0U4Q9UBL3Q9UPP1Q9Y5Z71:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC4938
PPP1CAPPP1CBPPP1CCPPP1R2PPP1R8P36873P41236P62136P62140Q129720:0:0:0:0hu.MAP2
ADISSPCNSTKIF18APPP1CAPPP1CCPPP1R8RIF1YLPM1P36873P49750P62136Q12972Q5UIP0Q6PJW8Q8NI77Q9GZN80:0:0:0:0:0:0:0hu.MAP
PPP1CAPPP1CBPPP1CCP36873P62136P621400:0:0KEGG-MEDICUS
ADISSPCNSTCSRNP2KIF18APPP1CAPPP1CCPPP1R8TANC2P36873P62136Q12972Q6PJW8Q8NI77Q9GZN8Q9H175Q9HCD60:0:0:0:0:0:0:0hu.MAP
PPP1CAP621362PDBPDB:6obuPDB:3e7bPDB:3e7aPDB:4movPDB:6obrPDB:8sw6PDB:4g9jPDB:6obsPDB:6alzPDB:6obq
PPP1CAPPP1R8P62136Q129724:4PDBPDB:3v4y
ADISSPKIF18APPP1CAPPP1R8P62136Q12972Q8NI77Q9GZN80:0:0:0hu.MAP
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry130379855
Sequence, Structure & Domains

Sequences

Length
330
Mass
37,512
Sequence
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P62136-1; Sequence=Displayed; Name=2; IsoId=P62136-2; Sequence=VSP_043377; Name=3; IsoId=P62136-3; Sequence=VSP_046754
Alternative Sequence
18; E -> EGSRVLTPHCAP (in isoform 2); 19..62; Missing (in isoform 3)

3D Structural Models

Turn
23..25; 115..117; 132..135; 166..168; 259..262
Helix
9..18; 19..21; 32..48; 69..79; 100..113; 124..126; 128..131; 136..143; 146..156; 183..187; 200..206; 229..239; 272..274
Beta Strand
51..55; 57..62; 87..89; 94..98; 118..120; 162..165; 169..171; 197..199; 214..218; 222..227; 242..246; 248..251; 254..258; 263..267; 280..285; 290..297
3D Structure
Electron microscopy (2); X-ray crystallography (43)

Domain & Motif Annotations

Region
306..330; Disordered
Protein Families (2)
  • PPP phosphatase family
  • PP-1 subfamily
Sequence Similarities
Belongs to the PPP phosphatase family. PP-1 subfamily.
Clinical Relevance
Related Diseases
Molluscum contagiosum
Biomarker
Approved
Drug Targets
Successful target
Drugs (5)
OKADAIC ACIDCANTHARIDINMICROCYSTIN-LRCHEMBL:CHEMBL1503729DEMETHYL-CANTHARIDIN
Antibody (2)
CAB004545HPA046833
Interaction Protein (57)
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
Interaction Count
57
Interaction Dataset (2)
intact_biogridintact_biogrid_bioplex
Supporting Publications26
PMIDTitleRelated sentences
36064647Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.No related sentences available
36146834Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.No related sentences available
36497184Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.No related sentences available
37204515Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.No related sentences available
37322475Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.No related sentences available
37926756Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells.No related sentences available
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No related sentences available
38207106Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.No related sentences available
39207047The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.No related sentences available
40189497Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.No related sentences available
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