Protein detail

PP1A

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)

Entry name
PP1A
UniProt ID
P62136
EVMP confidence score
0.75
Supporting publications (n)
26
Transmembrane count
Protein classification
EnzymesEssential proteinsPlasma proteinsPredicted intracellular proteins
Basic Information
Protein Names
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Protein Class (4)
EnzymesEssential proteinsPlasma proteinsPredicted intracellular proteins
Protein Function (3)
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Hydrolases
Ensembl
ENSG00000172531
Entrez Gene Symbol
PPP1CA
Gene Synonym (4)
PP-1APP1APP1alphaPPP1A
Gene Description
Protein phosphatase 1 catalytic subunit alpha
Chromosome
11
Position
67398181-67421183
Supporting publications (n)
26
EVMP confidence score
0.75
Fluorescence & Localization
Tissue SpecificcervixCell SpecificAdrenal cortex cellsBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted - unknown locationSecretome FunctionEnzyme
Function & Pathway
Protein Function (3)
  • Enzymes
  • Predicted intracellular proteins
  • ENZYME proteins:Hydrolases
Cellular Component (15)
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Molecular Function (10)
Biological Process (3)
KEGG (23)
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Reactome (21)
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Canonical Pathways
M200 Pid era genomic pathway
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence133

Enzyme-Mediated Modification (27)

27 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
PPP1CACDK12Q9NYV4T331phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CACDK16Q00536T331phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CACDK17Q00537T331phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CACDK18Q07002T331phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CACDK20Q8IZL9T331phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PPP1CAGSK3BP49841T320phosphorylationKEAKEA:17570479
PPP1CAPRKCAP17252S325phosphorylationKEAKEA:9399575
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Ligand-Receptor Signaling (5)

5 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Regulatory Interaction Network (44)

44 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PP1R8Q12972PP1AP62136YesYesLMPIDSIGNORHPRDHINTHuRIIntActDIPSPIKE_LCLit-BM-17Lit-BM-17:12788942IntAct:22940584IntAct:32296183SPIKE_LC:15231748HINT:25593058HINT:22940584SPIKE_LC:16189514IntAct:22365833IntAct:18842582Lit-BM-17:15231748LMPID:9353294HINT:10637318HINT:12788942Lit-BM-17:27173435DIP:22940584Lit-BM-17:26186194HINT:18842582Lit-BM-17:18842582Lit-BM-17:20516061Lit-BM-17:28330616HINT:33961781LMPID:20044954Lit-BM-17:10637318Lit-BM-17:20671031Lit-BM-17:22365833SIGNOR:1322907HINT:28330616HPRD:15231748LMPID:12657641IntAct:15231748
SHOC2Q9UQ13PP1AP62136YesYesHINTSIGNORHINT:35831509HINT:35830882HINT:36175670SIGNOR:16630891HINT:33961781
PP1AP62136STAT3P40763YesYesSIGNOR_ProtMapperSIGNORProtMapperProtMapper:19440292SIGNOR:19440292
PP1AP62136RAF1P04049YesYesSIGNOR_ProtMapperSIGNORProtMapperDEPODProtMapper:16630891SIGNOR:16630891DEPOD:7604263
CDK1P06493PP1AP62136YesYesphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAKinexus_KEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperLit-BM-17PhosphoSite_ProtMapperSPIKE_LCphosphoELM:9122166SPIKE_LC:17145710KEA:18088087KEA:97225924Lit-BM-17:17274640KEA:12202491SIGNOR:12202491KEA:9122166ProtMapper:12202491KEA:10880350
PP1AP62136IFIH1Q9BYX4YesYesInnateDBSIGNOR_ProtMapperSIGNORProtMapperSIGNOR:23499489ProtMapper:23499489InnateDB:23499489
PP1AP62136MK01P28482YesYesHPRDSIGNORSIGNOR:12840032HPRD:12624094
PP1AP62136CCND3P30281YesYesSIGNOR_ProtMapperSIGNORProtMapperProtMapper:16331257SIGNOR:16331257
PP1AP62136PROF1P07737YesYesSIGNOR_ProtMapperSIGNORProtMapperSIGNOR:22479341ProtMapper:22479341
PP1AP62136AURKAO14965YesYesHPRDSIGNORDEPODSIGNOR:11551964DEPOD:11039908HPRD:11551964
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Protein Complex Composition (56)

56 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CDK1HCFC1HCFC2HSPA4MARK4PKMYT1PPP1CAPRKG1P06493P34932P51610P62136Q13976Q96L34Q99640Q9Y5Z71:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC9506
CDK4HCFC1HSP90AA1HSPA4HSPA8KLHDC10MARK4PPP1CAPPP1CCRIPK3UBCWDR82P07900P0CG48P11142P11802P34932P36873P51610P62136Q6PID8Q6UXN9Q96L34Q9Y5721:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC5084
ASH2LCXXC1H3-4H3C11HCFC1HCFC2HSPA4HSPA8PHF8PPP1CASPOCD1WDR5WDR82P11142P34932P51610P61964P62136P68431Q16695Q6UXN9Q6ZMY3Q9P0U4Q9UBL3Q9UPP1Q9Y5Z71:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC4938
PPP1CAPPP1CBPPP1CCPPP1R2PPP1R8P36873P41236P62136P62140Q129720:0:0:0:0hu.MAP2
ADISSPCNSTKIF18APPP1CAPPP1CCPPP1R8RIF1YLPM1P36873P49750P62136Q12972Q5UIP0Q6PJW8Q8NI77Q9GZN80:0:0:0:0:0:0:0hu.MAP
PPP1CAPPP1CBPPP1CCP36873P62136P621400:0:0KEGG-MEDICUS
ADISSPCNSTCSRNP2KIF18APPP1CAPPP1CCPPP1R8TANC2P36873P62136Q12972Q6PJW8Q8NI77Q9GZN8Q9H175Q9HCD60:0:0:0:0:0:0:0hu.MAP
PPP1CAP621362PDBPDB:6obuPDB:3e7bPDB:3e7aPDB:4movPDB:6obrPDB:8sw6PDB:4g9jPDB:6obsPDB:6alzPDB:6obq
PPP1CAPPP1R8P62136Q129724:4PDBPDB:3v4y
ADISSPKIF18APPP1CAPPP1R8P62136Q12972Q8NI77Q9GZN80:0:0:0hu.MAP
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometry130379855
Sequence, Structure & Domains

Sequences

Length
330
Mass
37,512
Sequence
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P62136-1; Sequence=Displayed; Name=2; IsoId=P62136-2; Sequence=VSP_043377; Name=3; IsoId=P62136-3; Sequence=VSP_046754
Alternative Sequence
18; E -> EGSRVLTPHCAP (in isoform 2); 19..62; Missing (in isoform 3)

3D Structural Models

Turn
23..25; 115..117; 132..135; 166..168; 259..262
Helix
9..18; 19..21; 32..48; 69..79; 100..113; 124..126; 128..131; 136..143; 146..156; 183..187; 200..206; 229..239; 272..274
Beta Strand
51..55; 57..62; 87..89; 94..98; 118..120; 162..165; 169..171; 197..199; 214..218; 222..227; 242..246; 248..251; 254..258; 263..267; 280..285; 290..297
3D Structure
Electron microscopy (2); X-ray crystallography (43)

Domain & Motif Annotations

Region
306..330; Disordered
Protein Families (2)
  • PPP phosphatase family
  • PP-1 subfamily
Sequence Similarities
Belongs to the PPP phosphatase family. PP-1 subfamily.
Clinical Relevance
Related Diseases
Molluscum contagiosum
Biomarker
Approved
Drug Targets
Successful target
Drugs (5)
OKADAIC ACIDCANTHARIDINMICROCYSTIN-LRCHEMBL:CHEMBL1503729DEMETHYL-CANTHARIDIN
Antibody (2)
CAB004545HPA046833
Interaction Protein (57)
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
Interaction Count
57
Interaction Dataset (2)
intact_biogridintact_biogrid_bioplex
Supporting Publications26
PMIDTitleRelated sentences
26826536[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].No related sentences available
31805958Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.No related sentences available
32230970Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.No related sentences available
32854315Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
32916986Proteomic Approach for Searching for Universal, Tissue-Specific, and Line-Specific Markers of Extracellular Vesicles in Lung and Colorectal Adenocarcinoma Cell Lines.No related sentences available
33304478The proteomic landscape of small urinary extracellular vesicles during kidney transplantation.No related sentences available
33592500A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.No related sentences available
34064677Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells.No related sentences available
34473505Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.
34576246Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.No related sentences available
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