Protein detail
PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Protein symbol PP1A | UniProt ID | EVMP score 0.75 |
Frequency 26 | Transmembrane count | Protein classification EnzymesEssential proteinsPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16)
Protein Class
EnzymesEssential proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Ensembl
Entrez Gene Symbol
Gene Synonym
PP-1APP1APP1alphaPPP1A
Gene Description
Protein phosphatase 1 catalytic subunit alpha
Chromosome
11
Position
67398181-67421183
Frequency
26
EVMP Score
0.75
Fluorescence & Localization
Tissue SpecificcervixCell SpecificAdrenal cortex cellsBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted - unknown locationSecretome FunctionEnzyme
Function & Pathway
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component
- GO:0000781 chromosome, telomeric region
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005730 nucleolus
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005912 adherens junction
- GO:0042587 glycogen granule
- GO:0043197 dendritic spine
- GO:0043204 perikaryon
- GO:0070062 extracellular exosome
- GO:0072357 PTW/PP1 phosphatase complex
- GO:0098793 presynapse
- GO:0098978 glutamatergic synapse
Molecular Function
- GO:0004721 phosphoprotein phosphatase activity
- GO:0004722 protein serine/threonine phosphatase activity
- GO:0005506 iron ion binding
- GO:0005515 protein binding
- GO:0008157 protein phosphatase 1 binding
- GO:0016791 phosphatase activity
- GO:0017018 myosin phosphatase activity
- GO:0043021 ribonucleoprotein complex binding
- GO:0046914 transition metal ion binding
- GO:0098641 cadherin binding involved in cell-cell adhesion
Biological Process
KEGG
- hsa03015 mRNA surveillance pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04114 Oocyte meiosis
- KEGG:hsa04218 Cellular senescence
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04720 Long-term potentiation
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa04750 Inflammatory mediator regulation of TRP channels
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04910 Insulin signaling pathway
- KEGG:hsa04921 Oxytocin signaling pathway
- KEGG:hsa04931 Insulin resistance
- KEGG:hsa05031 Amphetamine addiction
- KEGG:hsa05034 Alcoholism
- KEGG:hsa05168 Herpes simplex virus 1 infection
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05415 Diabetic cardiomyopathy
Reactome
- R-hsa-9909396 circadian clock
- R-hsa-180024 darpp 32 events
- R-hsa-2173788 downregulation of tgf beta receptor signaling
- R-hsa-418594 g alpha i signalling events
- R-hsa-5663205 infectious disease
- R-hsa-556833 metabolism of lipids
- R-hsa-8953854 metabolism of rna
- R-hsa-72187 mrna 3 end processing
- R-hsa-9770562 mrna polyadenylation
- R-hsa-111885 opioid signalling
- R-hsa-9931530 phosphorylation and nuclear translocation of the cry per kinase complex
- R-hsa-72203 processing of capped intron containing pre mrna
- R-hsa-9820952 respiratory syncytial virus infection pathway
- R-hsa-9820965 respiratory syncytial virus rsv genome replication transcription and translation
- R-hsa-372790 signaling by gpcr
- R-hsa-9006936 signaling by tgfb family members
- R-hsa-170834 signaling by tgf beta receptor complex
- R-hsa-2173789 tgf beta receptor signaling activates smads
- R-hsa-163560 triglyceride catabolism
- R-hsa-8979227 triglyceride metabolism
- R-hsa-9824446 viral infection pathways
Canonical Pathways
M200 Pid era genomic pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
27 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PPP1CA | CDK3 | Q00526 | T | 331 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PPP1CA | CDK10 | Q15131 | T | 331 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PPP1CA | CDK4 | P11802 | T | 331 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PPP1CA | CDK6 | Q00534 | T | 331 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PPP1CA | CDK7 | P50613 | T | 331 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PPP1CA | CDK8 | P49336 | T | 331 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PPP1CA | CDK11B | P21127 | T | 331 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PPP1CA | CDK19 | Q9BWU1 | T | 331 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PPP1CA | CDK9 | P50750 | T | 331 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| PPP1CA | CDK13 | Q14004 | T | 331 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
44 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PP1A | P62136 | YAP1 | P46937 | Yes | Yes | No | HINTSIGNOR | HINT:24255178SIGNOR:21909427HINT:24366813 |
| CDK5 | Q00535 | PP1A | P62136 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperKEAKinexus_KEASIGNOR_ProtMapperPhosphoSite_ProtMapper | ProtMapper:17202132SIGNOR:17202132SIGNOR:12202491KEA:9122166ProtMapper:12202491 |
| PP1A | P62136 | MPIP3 | P30307 | Yes | Yes | No | SIGNORDEPODKinexus_KEAKEAWang | SIGNOR:14592972KEA:11897663KEA:9543386DEPOD:16467385DEPOD:14592972 |
| PP1A | P62136 | GCR | P04150 | Yes | Yes | No | SIGNORSparser_ProtMapperProtMapper | ProtMapper:32585168SIGNOR:32585168 |
| PP1A | P62136 | BRCA1 | P38398 | Yes | No | Yes | SIGNORProtMapperDEPODHPRDHINTBioGRIDLMPIDSIGNOR_ProtMapperSPIKE_LC | HPRD:12438214HINT:17511879BioGRID:25056273SIGNOR:17603999ProtMapper:17603999DEPOD:12438214HINT:12438214SPIKE_LC:17511879HINT:29764992DEPOD:17603999LMPID:17603999 |
| PP1A | P62136 | SP3 | Q02447 | Yes | No | Yes | SIGNOR | SIGNOR:12684058 |
| CDK2 | P24941 | PP1A | P62136 | Yes | No | Yes | BEL-Large-Corpus_ProtMapperSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_ProtMapperHPRD_MIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAKEAphosphoELM_KEASIGNOR_ProtMapperLit-BM-17NetworKIN_KEASPIKE_LC | ProtMapper:30661852ProtMapper:15212693ProtMapper:16550609SPIKE_LC:17145710KEA:18088087KEA:97225924Lit-BM-17:17274640KEA:12202491SIGNOR:12202491KEA:17570479KEA:9122166ProtMapper:12202491KEA:10880350ProtMapper:14715909 |
| PP1A | P62136 | PYR1 | P27708 | Yes | No | Yes | SIGNORProtMapperDEPODHPRDSIGNOR_ProtMapper | SIGNOR:4092695ProtMapper:4092695HPRD:4092695DEPOD:4092695 |
| PP1A | P62136 | IKZF1 | Q13422 | Yes | Yes | No | SIGNORDEPOD | DEPOD:19282287SIGNOR:21750978 |
| PP1A | P62136 | WWTR1 | Q9GZV5 | Yes | Yes | No | SIGNOR | SIGNOR:21189257 |
Protein Complex Composition
56 records.
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 30379855 |
Sequence, Structure & Domains
Sequences
Length
330
Mass
37,512
Sequence
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P62136-1; Sequence=Displayed; Name=2; IsoId=P62136-2; Sequence=VSP_043377; Name=3; IsoId=P62136-3; Sequence=VSP_046754
Alternative Sequence
18; E -> EGSRVLTPHCAP (in isoform 2); 19..62; Missing (in isoform 3)
3D Structural Models
Turn
23..25; 115..117; 132..135; 166..168; 259..262
Helix
9..18; 19..21; 32..48; 69..79; 100..113; 124..126; 128..131; 136..143; 146..156; 183..187; 200..206; 229..239; 272..274
Beta Strand
51..55; 57..62; 87..89; 94..98; 118..120; 162..165; 169..171; 197..199; 214..218; 222..227; 242..246; 248..251; 254..258; 263..267; 280..285; 290..297
3D Structure
Electron microscopy (2); X-ray crystallography (43)
Domain & Motif Annotations
Region
306..330; Disordered
Protein Families
- PPP phosphatase family
- PP-1 subfamily
Sequence Similarities
Belongs to the PPP phosphatase family. PP-1 subfamily.
Clinical Relevance
Related Diseases
Biomarker
Approved
Drug Targets
Successful target
Interaction Protein
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
Interaction Count
57
Interaction Dataset
intact_biogridintact_biogrid_bioplex