Protein detail

NCS1

Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)

Entry name NCS1	UniProt ID P62166	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000107130

Entrez Gene Symbol

NCS1

Gene Synonym (2)

FREQNCS-1

Gene Description

Neuronal calcium sensor 1

Chromosome

Position

130172404-130237303

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificbrainCell SpecificBrain excitatory neuronsBlood Cell SpecificNK-cell

Function & Pathway4

Protein Function

Predicted intracellular proteins

Cellular Component (8)

Molecular Function (4)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence17

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
NCS1	P62166	DRD2	P14416	Yes	No	Yes	HPRDLit-BM-17SIGNORBioGRID	SIGNOR:12351722 BioGRID:14709338 HPRD:12351722 Lit-BM-17:12351722
IRPL1	Q9NZN1	NCS1	P62166	Yes	Yes	No	HPRDLit-BM-17SIGNOR	SIGNOR:12783849 HPRD:12783849 Lit-BM-17:12783849
NCS1	P62166	ARBK1	P25098	Yes	No	Yes	HPRDSPIKE_LCSIGNOR	SIGNOR:12351722 HPRD:12351722 SPIKE_LC:16189514
IRPL2	Q9NP60	NCS1	P62166	Yes	Yes	No	SIGNOR	SIGNOR:12783849

Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ABHD6 BSPRY DEAF1 NCS1	O75398 P62166 Q5W0U4 Q9BV23	0:0:0:0	hu.MAP2
DCAF7 DYRK1A DYRK1B FBXO8 HIPK2 NCS1 PI4KB PPIL1 SFN UBC YWHAB YWHAG	P0CG48 P31946 P31947 P61962 P61981 P62166 Q13627 Q9H2X6 Q9NRD0 Q9UBF8 Q9Y3C6 Q9Y463	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3964
NCS1 NMT1	P30419 P62166	2:2	PDB	PDB:5o9s
HSD17B3 NCS1	P37058 P62166	0:0	hu.MAP
NCS1	P62166	2	PDB	PDB:1g8iPDB:4gukPDB:6qi4

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	4	38113368 32854315 31805958 38716512

Sequence, Structure & Domains12

Sequences

Length

190

Mass

21,879

Sequence

MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P62166-1; Sequence=Displayed; Name=2; IsoId=P62166-2; Sequence=VSP_046312

Alternative Sequence

1..22; MGKSNSKLKPEVVEELTRKTYF -> MATI (in isoform 2)

3D Structural Models

Helix

3..5; 10..18; 24..37; 45..55; 62..72; 82..94; 97..108; 118..132; 133..135; 139..141; 145..156; 157..159; 166..170; 177..183

Beta Strand

20..22; 41..43; 77..81; 109..111; 113..116; 142..144; 161..164

3D Structure

NMR spectroscopy (1); X-ray crystallography (7)

Domain & Motif Annotations

Domain (FT)

24..59; EF-hand 1; 60..95; EF-hand 2; 96..131; EF-hand 3; 144..179; EF-hand 4

Region

174..190; Interaction with IL1RAPL1

Protein Families

Recoverin family

Sequence Similarities

Belongs to the recoverin family.

Clinical Relevance4

Antibody (2)

CAB018587 HPA019713

Interaction Protein (2)

ENSG00000006432ENSG00000121289

Interaction Count

Interaction Dataset

biogrid_bioplex

Supporting Publications3

PMID	Title	Abstract
28240915	Quantitative Proteomic Analysis of Serum Exosomes from Patients with Locally Advanced Pancreatic Cancer Undergoing Chemoradiotherapy.	No abstract available
33017416	Proteomic analysis of plasma exosomes from Cystic Echinococcosis patients provides in vivo support for distinct immune response profiles in active vs inactive infection and suggests potential biomarkers.	No abstract available
33169421	A novel method of high-purity extracellular vesicle enrichment from microliter-scale human serum for proteomic analysis.	No abstract available