Protein detail
NCS1
Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)
Entry name NCS1 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
FREQNCS-1
Gene Description
Neuronal calcium sensor 1
Chromosome
9
Position
130172404-130237303
Supporting publications (n)
3
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neuronsBlood Cell SpecificNK-cell
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (8)
Molecular Function (4)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence17
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NCS1 | P62166 | DRD2 | P14416 | Yes | Yes | HPRDLit-BM-17SIGNORBioGRID | SIGNOR:12351722BioGRID:14709338HPRD:12351722Lit-BM-17:12351722 | |
| IRPL1 | Q9NZN1 | NCS1 | P62166 | Yes | Yes | HPRDLit-BM-17SIGNOR | SIGNOR:12783849HPRD:12783849Lit-BM-17:12783849 | |
| NCS1 | P62166 | ARBK1 | P25098 | Yes | Yes | HPRDSPIKE_LCSIGNOR | SIGNOR:12351722HPRD:12351722SPIKE_LC:16189514 | |
| IRPL2 | Q9NP60 | NCS1 | P62166 | Yes | Yes | SIGNOR | SIGNOR:12783849 |
Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ABHD6BSPRYDEAF1NCS1 | O75398P62166Q5W0U4Q9BV23 | 0:0:0:0 | hu.MAP2 | |||
| DCAF7DYRK1ADYRK1BFBXO8HIPK2NCS1PI4KBPPIL1SFNUBCYWHABYWHAG | P0CG48P31946P31947P61962P61981P62166Q13627Q9H2X6Q9NRD0Q9UBF8Q9Y3C6Q9Y463 | 1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC3964 | ||
| NCS1NMT1 | P30419P62166 | 2:2 | PDB | PDB:5o9s | ||
| HSD17B3NCS1 | P37058P62166 | 0:0 | hu.MAP | |||
| NCS1 | P62166 | 2 | PDB | PDB:1g8iPDB:4gukPDB:6qi4 |
Sequence, Structure & Domains
Sequences
Length
190
Mass
21,879
Sequence
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P62166-1; Sequence=Displayed; Name=2; IsoId=P62166-2; Sequence=VSP_046312
Alternative Sequence
1..22; MGKSNSKLKPEVVEELTRKTYF -> MATI (in isoform 2)
3D Structural Models
Helix
3..5; 10..18; 24..37; 45..55; 62..72; 82..94; 97..108; 118..132; 133..135; 139..141; 145..156; 157..159; 166..170; 177..183
Beta Strand
20..22; 41..43; 77..81; 109..111; 113..116; 142..144; 161..164
3D Structure
NMR spectroscopy (1); X-ray crystallography (7)
Domain & Motif Annotations
Domain (FT)
24..59; EF-hand 1; 60..95; EF-hand 2; 96..131; EF-hand 3; 144..179; EF-hand 4
Region
174..190; Interaction with IL1RAPL1
Protein Families
Recoverin family
Sequence Similarities
Belongs to the recoverin family.
Clinical Relevance
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 28240915 | Quantitative Proteomic Analysis of Serum Exosomes from Patients with Locally Advanced Pancreatic Cancer Undergoing Chemoradiotherapy. | No related sentences available |
| 33017416 | Proteomic analysis of plasma exosomes from Cystic Echinococcosis patients provides in vivo support for distinct immune response profiles in active vs inactive infection and suggests potential biomarkers. | No related sentences available |
| 33169421 | A novel method of high-purity extracellular vesicle enrichment from microliter-scale human serum for proteomic analysis. | No related sentences available |