Protein detail
PRS8
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Protein symbol PRS8 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Essential proteinsPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Protein Class
Essential proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
p45p45/SUGRPT6S8SUG-1SUG1TBP10TRIP1
Gene Description
Proteasome 26S subunit, ATPase 5
Chromosome
17
Position
63827152-63832026
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell Specificintermediate monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
- GO:0000502 proteasome complex
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0008540 proteasome regulatory particle, base subcomplex
- GO:0016020 membrane
- GO:0022624 proteasome accessory complex
- GO:0031410 cytoplasmic vesicle
- GO:0070062 extracellular exosome
- GO:0072562 blood microparticle
Molecular Function
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008134 transcription factor binding
- GO:0016887 ATP hydrolysis activity
- GO:0031531 thyrotropin-releasing hormone receptor binding
- GO:0036402 proteasome-activating activity
- GO:0140296 general transcription initiation factor binding
- GO:0140297 DNA-binding transcription factor binding
Biological Process
KEGG
- hsa03050 Proteasome
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05014 Amyotrophic lateral sclerosis
- KEGG:hsa05016 Huntington disease
- KEGG:hsa05017 Spinocerebellar ataxia
- KEGG:hsa05020 Prion disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05169 Epstein-Barr virus infection
Reactome
- R-hsa-382556 abc family proteins mediated transport
- R-hsa-5619084 abc transporter disorders
- R-hsa-176814 activation of apc c and apc c cdc20 mediated degradation of mitotic proteins
- R-hsa-1169091 activation of nf kappab in b cells
- R-hsa-1280218 adaptive immune system
- R-hsa-418990 adherens junctions interactions
- R-hsa-9931269 ampk induced erad and lysosome mediated degradation of pd l1 cd274
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-983168 antigen processing ubiquitination proteasome degradation
- R-hsa-174178 apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1
- R-hsa-174143 apc c mediated degradation of cell cycle proteins
- R-hsa-109581 apoptosis
- R-hsa-4608870 asymmetric localization of pcp proteins
- R-hsa-450408 auf1 hnrnp d0 binds and destabilizes mrna
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-69017 cdk mediated phosphorylation and removal of cdc6
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9711123 cellular response to chemical stress
- R-hsa-1234174 cellular response to hypoxia
- R-hsa-1500931 cell cell communication
- R-hsa-1640170 cell cycle
- R-hsa-69620 cell cycle checkpoints
- R-hsa-69278 cell cycle mitotic
- R-hsa-446728 cell junction organization
- R-hsa-9909396 circadian clock
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-5607764 clec7a dectin 1 signaling
- R-hsa-389948 co inhibition by pd 1
- R-hsa-1236978 cross presentation of soluble exogenous antigens endosomes
- R-hsa-69656 cyclin a cdk2 associated events at s phase entry
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-5607761 dectin 1 mediated noncanonical nf kb signaling
- R-hsa-4641257 degradation of axin
- R-hsa-195253 degradation of beta catenin by the destruction complex
- R-hsa-9932298 degradation of cry and per proteins
- R-hsa-4641258 degradation of dvl
- R-hsa-5610780 degradation of gli1 by the proteasome
- R-hsa-5688426 deubiquitination
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-69306 dna replication
- R-hsa-69002 dna replication pre initiation
- R-hsa-1168372 downstream signaling events of b cell receptor bcr
- R-hsa-202424 downstream tcr signaling
- R-hsa-8854050 fbxl7 down regulates aurka during mitotic entry and in early mitosis
- R-hsa-2871837 fceri mediated nf kb activation
- R-hsa-2454202 fc epsilon receptor fceri signaling
- R-hsa-9793380 formation of paraxial mesoderm
- R-hsa-69615 g1 s dna damage checkpoints
- R-hsa-69481 g2 m checkpoints
- R-hsa-9758941 gastrulation
- R-hsa-9929356 gsk3b mediated proteasomal degradation of pd l1 cd274
- R-hsa-5358346 hedgehog ligand biogenesis
- R-hsa-5610787 hedgehog off state
- R-hsa-5632684 hedgehog on state
- R-hsa-5387390 hh mutants abrogate ligand secretion
- R-hsa-162906 hiv infection
- R-hsa-162909 host interactions of hiv factors
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-446652 interleukin 1 family signaling
- R-hsa-9020702 interleukin 1 signaling
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-9755511 keap1 nfe2l2 pathway
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-5687128 mapk6 mapk4 signaling
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-71291 metabolism of amino acids and derivatives
- R-hsa-351202 metabolism of polyamines
- R-hsa-8953854 metabolism of rna
- R-hsa-453279 mitotic g1 phase and g1 s transition
- R-hsa-453274 mitotic g2 g2 m phases
- R-hsa-2555396 mitotic metaphase and anaphase
- R-hsa-68886 m phase
- R-hsa-8951664 neddylation
- R-hsa-9604323 negative regulation of notch4 signaling
- R-hsa-9675108 nervous system development
- R-hsa-9759194 nuclear events mediated by nfe2l2
- R-hsa-68949 orc1 removal from chromatin
- R-hsa-69563 p53 dependent g1 dna damage response
- R-hsa-4086400 pcp ce pathway
- R-hsa-597592 post translational protein modification
- R-hsa-5357801 programmed cell death
- R-hsa-9907900 proteasome assembly
- R-hsa-6807070 pten regulation
- R-hsa-169911 regulation of apoptosis
- R-hsa-9764561 regulation of cdh1 function
- R-hsa-9010553 regulation of expression of slits and robos
- R-hsa-9759476 regulation of homotypic cell cell adhesion
- R-hsa-450531 regulation of mrna stability by proteins that bind au rich elements
- R-hsa-350562 regulation of ornithine decarboxylase odc
- R-hsa-9909648 regulation of pd l1 cd274 expression
- R-hsa-9909615 regulation of pd l1 cd274 post translational modification
- R-hsa-8948751 regulation of pten stability and activity
- R-hsa-5658442 regulation of ras by gaps
- R-hsa-8939902 regulation of runx2 expression and activity
- R-hsa-8941858 regulation of runx3 expression and activity
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-9948299 ribosome associated quality control
- R-hsa-9954709 ribosome quality control rqc complex extracts and degrades nascent peptide
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-8939236 runx1 regulates transcription of genes involved in differentiation of hscs
- R-hsa-174113 scf beta trcp mediated degradation of emi1
- R-hsa-187577 scf skp2 mediated degradation of p27 p21
- R-hsa-2467813 separation of sister chromatids
- R-hsa-5358351 signaling by hedgehog
- R-hsa-449147 signaling by interleukins
- R-hsa-157118 signaling by notch
- R-hsa-9013694 signaling by notch4
- R-hsa-376176 signaling by robo receptors
- R-hsa-983705 signaling by the b cell receptor bcr
- R-hsa-195721 signaling by wnt
- R-hsa-9824272 somitogenesis
- R-hsa-9929491 spop mediated proteasomal degradation of pd l1 cd274
- R-hsa-69541 stabilization of p53
- R-hsa-69052 switching of origins to a post replicative state
- R-hsa-69239 synthesis of dna
- R-hsa-69242 s phase
- R-hsa-201681 tcf dependent signaling in response to wnt
- R-hsa-202403 tcr signaling
- R-hsa-8852276 the role of gtse1 in g2 m progression after g2 checkpoint
- R-hsa-5668541 tnfr2 non canonical nf kb pathway
- R-hsa-8878171 transcriptional regulation by runx1
- R-hsa-8878166 transcriptional regulation by runx2
- R-hsa-8878159 transcriptional regulation by runx3
- R-hsa-72766 translation
- R-hsa-382551 transport of small molecules
- R-hsa-75815 ubiquitin dependent degradation of cyclin d
- R-hsa-69601 ubiquitin mediated degradation of phosphorylated cdc25a
- R-hsa-5689880 ub specific processing proteases
- R-hsa-5689603 uch proteinases
- R-hsa-180585 vif mediated degradation of apobec3g
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PSMC5 | PRKACA | P17612 | S | 120 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| HERC1 | Q15751 | PRS8 | P62195 | Yes | No | Yes | SIGNOR | SIGNOR:34446601 |
| KAPCA | P17612 | PRS8 | P62195 | Yes | No | No | PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:23275441PhosphoSite:17565987 |
Protein Complex Composition
56 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37713494 |
Sequence, Structure & Domains
Sequences
Length
406
Mass
45,626
Sequence
MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P62195-1; Sequence=Displayed; Name=2; IsoId=P62195-2; Sequence=VSP_045441
Alternative Sequence
1..8; Missing (in isoform 2)
3D Structural Models
Turn
118..120; 163..166; 224..226; 238..241; 251..254; 303..306; 308..310
Helix
22..65; 105..107; 148..150; 155..162; 167..170; 173..178; 198..205; 227..237; 268..280; 322..333; 344..349; 356..372; 380..391; 399..402
Beta Strand
71..79; 81..83; 85..92; 94..97; 133..136; 191..195; 209..213; 243..247; 262..265; 281..284; 287..291; 298..301; 336..338; 376..378
3D Structure
Electron microscopy (77); NMR spectroscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Region
186..406; May mediate interaction with PRPF9
Protein Families
AAA ATPase family
Sequence Similarities
Belongs to the AAA ATPase family.
Clinical Relevance
Interaction Protein
ENSG00000008018ENSG00000013275ENSG00000023902ENSG00000041357ENSG00000069667ENSG00000095261ENSG00000099341ENSG00000100519ENSG00000100764ENSG00000101843ENSG00000103035ENSG00000105048ENSG00000106588ENSG00000108344ENSG00000108671ENSG00000115233ENSG00000116750ENSG00000130706ENSG00000136940ENSG00000143106ENSG00000143365ENSG00000143549ENSG00000154839ENSG00000159352ENSG00000161057ENSG00000163161ENSG00000163636ENSG00000165916ENSG00000168286ENSG00000171346ENSG00000171360ENSG00000172354ENSG00000175166ENSG00000175354ENSG00000175575ENSG00000176101ENSG00000185627ENSG00000197170ENSG00000204889
Interaction Count
39
Interaction Dataset
biogrid_opencellintact_biogrid_opencellintact_biogridbiogrid_bioplexintact_biogrid_bioplexintact_biogrid_opencell_bioplexbiogrid_opencell_bioplex