Protein detail
PRS8
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Entry name PRS8 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Essential proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Protein Class (3)
Essential proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (8)
p45p45/SUGRPT6S8SUG-1SUG1TBP10TRIP1
Gene Description
Proteasome 26S subunit, ATPase 5
Chromosome
17
Position
63827152-63832026
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization4
Cell SpecificAlveolar cells type 1Single-Nuclei Brain Specificendothelial cellBlood Cell Specificintermediate monocyteBlood Lineage Specificdendritic cells
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (11)
- GO:0000502 proteasome complex
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0008540 proteasome regulatory particle, base subcomplex
- GO:0016020 membrane
- GO:0022624 proteasome accessory complex
- GO:0031410 cytoplasmic vesicle
- GO:0070062 extracellular exosome
Page 1 of 2
Molecular Function (8)
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0008134 transcription factor binding
- GO:0016887 ATP hydrolysis activity
- GO:0031531 thyrotropin-releasing hormone receptor binding
- GO:0036402 proteasome-activating activity
- GO:0140296 general transcription initiation factor binding
- GO:0140297 DNA-binding transcription factor binding
Biological Process (3)
KEGG (9)
- hsa03050 Proteasome
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05014 Amyotrophic lateral sclerosis
- KEGG:hsa05016 Huntington disease
- KEGG:hsa05017 Spinocerebellar ataxia
- KEGG:hsa05020 Prion disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05169 Epstein-Barr virus infection
Reactome (134)
- R-hsa-382556 abc family proteins mediated transport
- R-hsa-5619084 abc transporter disorders
- R-hsa-176814 activation of apc c and apc c cdc20 mediated degradation of mitotic proteins
- R-hsa-1169091 activation of nf kappab in b cells
- R-hsa-1280218 adaptive immune system
- R-hsa-418990 adherens junctions interactions
- R-hsa-9931269 ampk induced erad and lysosome mediated degradation of pd l1 cd274
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-983168 antigen processing ubiquitination proteasome degradation
- R-hsa-174178 apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1
Page 1 of 14
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence64
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PSMC5 | PRKACA | P17612 | S | 120 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| HERC1 | Q15751 | PRS8 | P62195 | Yes | No | Yes | SIGNOR | SIGNOR:34446601 |
| KAPCA | P17612 | PRS8 | P62195 | Yes | No | No | PhosphoSite_MIMPMIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:23275441PhosphoSite:17565987 |
Protein Complex Composition (56)
56 records.
Page 6 of 6Previous
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37713494 |
Sequence, Structure & Domains12
Sequences
Length
406
Mass
45,626
Sequence
MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P62195-1; Sequence=Displayed; Name=2; IsoId=P62195-2; Sequence=VSP_045441
Alternative Sequence
1..8; Missing (in isoform 2)
3D Structural Models
Turn
118..120; 163..166; 224..226; 238..241; 251..254; 303..306; 308..310
Helix
22..65; 105..107; 148..150; 155..162; 167..170; 173..178; 198..205; 227..237; 268..280; 322..333; 344..349; 356..372; 380..391; 399..402
Beta Strand
71..79; 81..83; 85..92; 94..97; 133..136; 191..195; 209..213; 243..247; 262..265; 281..284; 287..291; 298..301; 336..338; 376..378
3D Structure
Electron microscopy (77); NMR spectroscopy (1); X-ray crystallography (1)
Domain & Motif Annotations
Region
186..406; May mediate interaction with PRPF9
Protein Families
AAA ATPase family
Sequence Similarities
Belongs to the AAA ATPase family.
Clinical Relevance5
Interaction Protein (39)
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
Interaction Count
39
Interaction Dataset (7)
biogrid_opencellintact_biogrid_opencellintact_biogridbiogrid_bioplexintact_biogrid_bioplexintact_biogrid_opencell_bioplexbiogrid_opencell_bioplex
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37842978 | Dual-Recognition Triggered Proximity Ligation Combined with a Rolling Circle Amplification Strategy for Analysis of Exosomal Protein-Specific Glycosylation. | When detecting the glycosylated PD-L1 on MDA-MB-231 exosomes and glycosylated PTK7 on HepG2 exosomes, the detection limits were calculated to be as low as 1.04 × 10 |