Protein detail

GBB1

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)

Entry name GBB1	UniProt ID P62873	EVMP confidence score 0.88
Supporting publications (n) 42	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsRAS pathway related proteinsTransporters

Basic Information

Protein Names

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)

Protein Class (8)

Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsRAS pathway related proteinsTransporters

Protein Function (7)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
Potential drug targets
RAS pathway related proteins
Transporters:Accessory Factors Involved in Transport
Disease related genes

Ensembl

ENSG00000078369

Entrez Gene Symbol

GNB1

Gene Description

G protein subunit beta 1

Chromosome

Position

1785285-1892292

Supporting publications (n)

EVMP confidence score

0.88

Fluorescence & Localization

Cell SpecificAlveolar cells type 1Single-Nuclei Brain SpecificleukocyteBlood Cell SpecificneutrophilSecretome LocationSecreted to bloodSecretome FunctionComplement pathway

Function & Pathway

Protein Function (7)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
Potential drug targets
RAS pathway related proteins
Transporters:Accessory Factors Involved in Transport
Disease related genes

Cellular Component (10)

Molecular Function (5)

Biological Process (3)

KEGG (22)

Page 1 of 3

Reactome (65)

Page 1 of 7

Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence31

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
GNB1	NME2	P22392	H	266	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	OmniPath
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes
adhesion	adhesion	OmniPath	Yes	Yes
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes
plasma_membrane	plasma_membrane	Cellinker
plasma_membrane	plasma_membrane	OmniPath

Regulatory Interaction Network (10)

10 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GBB1	P62873	PLCB2	Q00722	Yes	Yes		WangSIGNOR	SIGNOR:1465133
SMO	Q99835	GBB1	P62873	Yes	Yes		WangHINTSIGNOR	SIGNOR:16885213 SIGNOR:23074268 HINT:31168089 HINT:32929279
GPSM3	Q9Y4H4	GBB1	P62873	Yes		Yes	SIGNOR	SIGNOR:22843681
FZD3	Q9NPG1	GBB1	P62873	Yes	Yes		WangSIGNOR	SIGNOR:17251915
GBB1	P62873		COMPLEX:P27986_P42336	Yes	Yes		SIGNOR	SIGNOR:16537363
GPER1	Q99527	GBB1	P62873	Yes	Yes		SIGNOR	SIGNOR:10696571
GBB1	P62873	PLCB1	Q9NQ66	Yes	Yes	Yes	WangSIGNOR	SIGNOR:8870665
GBG2	P59768	GBB1	P62873	Yes	Yes		SIGNORHPRDHINTIntActDIPWangLit-BM-17	HINT:33811074 HINT:38509098 HINT:35940205 HINT:32929279 HINT:35353559 HINT:35687690 HINT:38055679 HINT:38431681 HINT:30213947 HINT:35013280 HINT:37673067 HINT:34239071 HINT:38298116 HINT:35982227 HINT:35418677 HINT:35610220 HINT:32004460 HINT:36173843 HINT:37292845 HINT:38182578 HINT:30209400 HINT:35245122 HINT:35365755 HINT:36450356 Lit-BM-17:18611381 HINT:29726815 HINT:36849514 HINT:36922494 HINT:35537452 HINT:36103815 HINT:32296767 HINT:36064945 HINT:36108005 HINT:35501348 HINT:36882417 HINT:37433790 HINT:38603770 HINT:38647423 HINT:31080070 HINT:34526663 HINT:33571432 HINT:37120430 IntAct:23739333 HINT:35835867 HINT:33961781 HINT:38720072 HINT:31915381 HINT:37743365 HINT:37991948 HINT:35365641 HINT:32004463 HINT:32690941 HINT:35418678 HINT:37733739 HINT:35714614 HINT:37963465 HINT:36563137 HINT:29925951 HINT:32193322 HINT:37225986 HINT:36127364 Lit-BM-17:19168127 HINT:36411392 HINT:34556863 HINT:37155313 HINT:37973972 HINT:37919470 HINT:37347749 HINT:38168118 HINT:37286794 Lit-BM-17:15889144 HINT:36922591 HINT:37591889 HINT:32371397 HINT:32076264 HINT:12782285 HINT:37051308 Lit-BM-17:15782186 HINT:34194039 HINT:32698187 HINT:34453129 HINT:38335293 HINT:38012179 HINT:15889144 HINT:28437792 HINT:34547628 HINT:36105372 HINT:36385145 HINT:34433901 HINT:35440625 HINT:37952153 HINT:32807782 HINT:37277332 HINT:34949837 HINT:38287117 HINT:34239069 HINT:38198545 HINT:36588120 HINT:34083522 HINT:29466332 HINT:35271311 HINT:12606627 HINT:34260945 HINT:36525977 HINT:36989299 HINT:37741852 HINT:35027551 Lit-BM-17:12606627 HINT:36309016 HINT:18611381 DIP:23739333 HINT:36806352 HINT:34497422 HINT:37450587 HINT:37563160 HINT:34937912 Lit-BM-17:12782285 HINT:36917754 HINT:32732395 HINT:36862765 HINT:36921049 HINT:37001505 HINT:35132089 HINT:29925945 HINT:34789875 HINT:36450989 HINT:37221270 HINT:38177682 HINT:37285260 HINT:37537379 HINT:35324283 HINT:36138141 HINT:33858992 HINT:37852260 Lit-BM-17:19376773 HINT:35418682 HINT:38062020 HINT:34135510 HINT:38753765 HINT:34020960 HINT:37160876 HINT:38012147 HINT:38065938 HINT:37478163 HINT:38428423 HINT:37081311 HINT:32219215 HINT:38552625 HINT:35637350 HINT:35446253 HINT:34545189 HINT:15782186 HINT:34789874 HINT:36639690 HPRD:11294873 HINT:36575181 HINT:37138078 HINT:36543774 HINT:36593162 DIP:18611381 HINT:35851571 HINT:36087581 HINT:35970999 HINT:38191689 HINT:35507650 HINT:32610344 HINT:36973264 HINT:35333651 HINT:37327704 HINT:37945893 HINT:34216564 HINT:32528175 HINT:37863901 HINT:37597514 HINT:38625940 HINT:34230484 HINT:35241677 HINT:36690613 HINT:37172014 HINT:38052802 HINT:37286793 HINT:36720854 HINT:35676276 HINT:37935376 HINT:30814734 HINT:23739333 HINT:36881626 SIGNOR:10696571 HINT:37524305 HINT:30639101 HINT:38332368 HINT:36721851 HINT:38418462 HINT:36724251 HINT:37770763 HINT:33264604 HINT:32811827 HINT:38306437 HINT:38589608 HINT:38632411 Lit-BM-17:9789084 HINT:37709767 HINT:29899455 HINT:31073061 HINT:35858343 HINT:36302898 HINT:34417468 HINT:32004470 HINT:35940204 HINT:38048360 HINT:36810324 HINT:37737235 HINT:38630816 HINT:33547286 HINT:36575163 HINT:35672283 HINT:31243364 HINT:32047270 HINT:33664408 HINT:33911284 HINT:34937906 HINT:35594396 HINT:37148874 HINT:38040762 HINT:38326620 HINT:38480881 HINT:38446662 HINT:34878828 HINT:38376112 HINT:33548201 HINT:37160891 HINT:33038544 HINT:37216523 HINT:37673901 HINT:16301321 HINT:37461561 HINT:33571431 HINT:38740791 HINT:33177239 Lit-BM-17:10339615 HINT:35739238 HINT:33762731 HINT:37038975 HINT:31168089 HINT:32724086 HINT:33828102 HINT:35570218 HINT:36396650 HINT:35614071 HINT:34916631 HINT:35767622 HINT:28323425 HINT:33957078 HINT:32004469 HINT:38215752 HINT:36823105 HINT:37932263 HINT:31740855 HPRD:8636150 HINT:33408414 HINT:32060286 HINT:27050625 HINT:35606397 HINT:36171289 HINT:34711980 HINT:37993467 HINT:37935377 HINT:35977511 HINT:35385593 HINT:35913979 HINT:35418679 HINT:35412894 HINT:35817871 HINT:37039481 HINT:38744983 HINT:33027691 HINT:35210615 HINT:36283409
GBB1	P62873	GBG2	P59768	Yes	Yes		SIGNORHPRDHINTIntActDIPWangLit-BM-17	HINT:33811074 HINT:38509098 HINT:35940205 HINT:32929279 HINT:35353559 HINT:35687690 HINT:38055679 HINT:38431681 HINT:30213947 HINT:35013280 HINT:37673067 HINT:34239071 HINT:38298116 HINT:35982227 HINT:35418677 HINT:35610220 HINT:32004460 HINT:36173843 HINT:37292845 HINT:38182578 HINT:30209400 HINT:35245122 HINT:35365755 HINT:36450356 Lit-BM-17:18611381 HINT:29726815 HINT:36849514 HINT:36922494 HINT:35537452 HINT:36103815 HINT:32296767 HINT:36064945 HINT:36108005 HINT:35501348 HINT:36882417 HINT:37433790 HINT:38603770 HINT:38647423 HINT:31080070 HINT:34526663 HINT:33571432 HINT:37120430 IntAct:23739333 HINT:35835867 HINT:33961781 HINT:38720072 HINT:31915381 HINT:37743365 HINT:37991948 HINT:35365641 HINT:32004463 HINT:32690941 HINT:35418678 HINT:37733739 HINT:35714614 HINT:37963465 HINT:36563137 HINT:29925951 HINT:32193322 HINT:37225986 HINT:36127364 Lit-BM-17:19168127 HINT:36411392 HINT:34556863 HINT:37155313 HINT:37973972 HINT:37919470 HINT:37347749 HINT:38168118 HINT:37286794 Lit-BM-17:15889144 HINT:36922591 HINT:37591889 HINT:32371397 HINT:32076264 HINT:12782285 HINT:37051308 Lit-BM-17:15782186 HINT:34194039 HINT:32698187 HINT:34453129 HINT:38335293 HINT:38012179 HINT:15889144 HINT:28437792 HINT:34547628 HINT:36105372 HINT:36385145 HINT:34433901 HINT:35440625 HINT:37952153 HINT:32807782 HINT:37277332 HINT:34949837 HINT:38287117 HINT:34239069 HINT:38198545 HINT:36588120 HINT:34083522 HINT:29466332 HINT:35271311 HINT:12606627 HINT:34260945 HINT:36525977 HINT:36989299 HINT:37741852 HINT:35027551 Lit-BM-17:12606627 HINT:36309016 HINT:18611381 DIP:23739333 HINT:36806352 HINT:34497422 HINT:37450587 HINT:37563160 HINT:34937912 Lit-BM-17:12782285 HINT:36917754 HINT:32732395 HINT:36862765 HINT:36921049 HINT:37001505 HINT:35132089 HINT:29925945 HINT:34789875 HINT:36450989 HINT:37221270 HINT:38177682 HINT:37285260 HINT:37537379 HINT:35324283 HINT:36138141 HINT:33858992 HINT:37852260 Lit-BM-17:19376773 HINT:35418682 HINT:38062020 HINT:34135510 HINT:38753765 HINT:34020960 HINT:37160876 HINT:38012147 HINT:38065938 HINT:37478163 HINT:38428423 HINT:37081311 HINT:32219215 HINT:38552625 HINT:35637350 HINT:35446253 HINT:34545189 HINT:15782186 HINT:34789874 HINT:36639690 HPRD:11294873 HINT:36575181 HINT:37138078 HINT:36543774 HINT:36593162 DIP:18611381 HINT:35851571 HINT:36087581 HINT:35970999 HINT:38191689 HINT:35507650 HINT:32610344 HINT:36973264 HINT:35333651 HINT:37327704 HINT:37945893 HINT:34216564 HINT:32528175 HINT:37863901 HINT:37597514 HINT:38625940 HINT:34230484 HINT:35241677 HINT:36690613 HINT:37172014 HINT:38052802 HINT:37286793 HINT:36720854 HINT:35676276 HINT:37935376 HINT:30814734 HINT:23739333 HINT:36881626 SIGNOR:10696571 HINT:37524305 HINT:30639101 HINT:38332368 HINT:36721851 HINT:38418462 HINT:36724251 HINT:37770763 HINT:33264604 HINT:32811827 HINT:38306437 HINT:38589608 HINT:38632411 Lit-BM-17:9789084 HINT:37709767 HINT:29899455 HINT:31073061 HINT:35858343 HINT:36302898 HINT:34417468 HINT:32004470 HINT:35940204 HINT:38048360 HINT:36810324 HINT:37737235 HINT:38630816 HINT:33547286 HINT:36575163 HINT:35672283 HINT:31243364 HINT:32047270 HINT:33664408 HINT:33911284 HINT:34937906 HINT:35594396 HINT:37148874 HINT:38040762 HINT:38326620 HINT:38480881 HINT:38446662 HINT:34878828 HINT:38376112 HINT:33548201 HINT:37160891 HINT:33038544 HINT:37216523 HINT:37673901 HINT:16301321 HINT:37461561 HINT:33571431 HINT:38740791 HINT:33177239 Lit-BM-17:10339615 HINT:35739238 HINT:33762731 HINT:37038975 HINT:31168089 HINT:32724086 HINT:33828102 HINT:35570218 HINT:36396650 HINT:35614071 HINT:34916631 HINT:35767622 HINT:28323425 HINT:33957078 HINT:32004469 HINT:38215752 HINT:36823105 HINT:37932263 HINT:31740855 HPRD:8636150 HINT:33408414 HINT:32060286 HINT:27050625 HINT:35606397 HINT:36171289 HINT:34711980 HINT:37993467 HINT:37935377 HINT:35977511 HINT:35385593 HINT:35913979 HINT:35418679 HINT:35412894 HINT:35817871 HINT:37039481 HINT:38744983 HINT:33027691 HINT:35210615 HINT:36283409
GBB1	P62873	PK3CA	P42336	Yes	Yes		WangCui2007SIGNOR	SIGNOR:16537363

Protein Complex Composition (10)

10 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
GNAI1-GNB1-GNG12 complex	GNAI1 GNB1	P62873 P63096	0:0	CORUM	CORUM:7086	25733868
GNAI1-GNB1-GNG13 complex	GNAI1 GNB1 GNG13	P62873 P63096 Q9P2W3	0:0:0	CORUM	CORUM:7092	25733868
GNAI1-GNB1-GNG4 complex	GNAI1 GNB1 GNG4	P50150 P62873 P63096	0:0:0	CORUM	CORUM:7031	25733868
GNAI1-GNB1-GNG8 complex	GNAI1 GNB1 GNG8	P62873 P63096 Q9UK08	0:0:0	CORUM	CORUM:7071	25733868
GNAI1-GNGT1-GNB1 complex	GNAI1 GNB1 GNGT1	P62873 P63096 P63211	0:0:0	CORUM	CORUM:7014	25733868
GPR88-Gi1 signaling complex	GNAI1 GNB1 GNGT1 GPR88	P62873 P63096 P63211 Q9GZN0	1:1:1:1	ComplexPortal	PDB:7EJXPDB:7WZ4intact:EBI-48416470	35501348 14755292
	ATM ATR BLM FANCM GNB1L HSPA4 MSH6 PRKDC RAD51 RPA1 RPA2 TELO2 TTI1 WRN	O43156 P15927 P27694 P34932 P52701 P54132 P78527 Q06609 Q13315 Q13535 Q14191 Q8IYD8 Q9BYB4 Q9Y4R8	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3776
	CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 GNB1 IGBP1 PDCL PPP2CB PPP2R2A PPP2R2C PPP2R2D PPP4C TCP1	P17987 P40227 P48643 P49368 P50991 P60510 P62714 P62873 P63151 P78318 P78371 Q13371 Q66LE6 Q99832 Q9Y2T4	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6341
	GNB1 GNG4	P50150 P62873	0:0	hu.MAP
	GNB1 GNG12	P62873 Q9UBI6	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	R Sequencing	2	37786918 32089743

Sequence, Structure & Domains

Sequences

Length

340

Mass

37,377

Sequence

MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P62873-1; Sequence=Displayed; Name=2; IsoId=P62873-2; Sequence=VSP_055232

Alternative Sequence

329..340; TGSWDSFLKIWN -> SVLG (in isoform 2)

3D Structural Models

Turn

34..36; 75..77; 84..86; 162..164; 171..174; 193..195; 213..215; 235..237; 246..248; 255..258; 299..301

Helix

3..25; 30..33; 267..269

Beta Strand

46..52; 54..56; 58..63; 67..74; 78..83; 89..94; 96..98; 100..105; 109..116; 117..119; 121..126; 129..131; 134..139; 146..161; 166..170; 175..180; 187..192; 196..203; 206..212; 218..223; 225..227; 229..234; 238..245; 250..254; 259..264; 273..278; 280..289; 290..292; 294..298; 304..308; 315..320; 322..325; 327..331; 334..340

3D Structure

Electron microscopy (950); X-ray crystallography (17)

Domain & Motif Annotations

Repeat

46..94; WD 1; 95..140; WD 2; 141..181; WD 3; 182..223; WD 4; 224..267; WD 5; 268..309; WD 6; 310..340; WD 7

Protein Families

WD repeat G protein beta family

Sequence Similarities

Belongs to the WD repeat G protein beta family.

Clinical Relevance

Disease Involvement (3)

Cancer-related genesDisease variantIntellectual disability

Related Diseases

Intellectual disability

Antibody (2)

HPA040736 HPA074924

Interaction Protein (22)

ENSG00000065135ENSG00000087258ENSG00000087460ENSG00000088256ENSG00000105701ENSG00000109971ENSG00000110651ENSG00000114353ENSG00000114450ENSG00000115484ENSG00000127928ENSG00000127955ENSG00000136940ENSG00000146731ENSG00000150753ENSG00000156052ENSG00000166226ENSG00000172380ENSG00000174021ENSG00000176533ENSG00000186469ENSG00000242616

Interaction Count

Interaction Dataset (6)

biogrid_opencell_bioplexbiogrid_opencellintact_biogrid_opencellbiogrid_bioplexintact_biogridintact_biogrid_opencell_bioplex

Supporting Publications42

PMID	Title	Related sentences
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No related sentences available
33893753	Label-free quantitative proteomic analysis of extracellular vesicles released from fibroblasts derived from patients with spinal muscular atrophy.	No related sentences available
34064677	Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells.	No related sentences available
34473505	Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.	Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.
34576246	Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.	No related sentences available
34815502	The von Willebrand factor stamps plasmatic extracellular vesicles from glioblastoma patients.	No related sentences available
35119778	Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis.	No related sentences available
35359923	TMT-Based Quantitative Proteomics Analysis of Synovial Fluid-Derived Exosomes in Inflammatory Arthritis.	No related sentences available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No related sentences available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No related sentences available

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