EV MemProt Atlas

Basic Information

Protein Names

Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B)

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Ensembl

ENSG00000119048

Entrez Gene Symbol

UBE2B

Frequency

1

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificLate spermatids

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Enzymes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04120 Ubiquitin mediated proteolysis

Reactome

Mediation Categories

Immune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

8 records.

Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
COMPLEX:A0AVT1_P0CG47	UBE2B	P63146	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:A0AVT1_P62979	UBE2B	P63146	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:A0AVT1_P0CG48	UBE2B	P63146	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:A0AVT1_P62987	UBE2B	P63146	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P22314_P62979	UBE2B	P63146	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P22314_P62987	UBE2B	P63146	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG47_P22314	UBE2B	P63146	Yes	Yes	No	SIGNOR	SIGNOR:34199813
COMPLEX:P0CG48_P22314	UBE2B	P63146	Yes	Yes	No	SIGNOR	SIGNOR:34199813

Protein Complex Composition

21 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
Ub:E2	UBB UBE2B	P0CG47 P63146	0:0	SIGNOR	SIGNOR:SIGNOR-C497
Ub:E2	UBC UBE2B	P0CG48 P63146	0:0	SIGNOR	SIGNOR:SIGNOR-C497
Ub:E2	RPS27A UBE2B	P62979 P63146	0:0	SIGNOR	SIGNOR:SIGNOR-C497
Ub:E2	UBA52 UBE2B	P62987 P63146	0:0	SIGNOR	SIGNOR:SIGNOR-C497
	POMP PSMA1 PSMA2 PSMA4 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 UBE2B UBR2	O14818 P20618 P25786 P25787 P25789 P28070 P28072 P28074 P49720 P49721 P60900 P63146 Q8IWV8 Q99436 Q9Y244	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6725
	HLTF PCNA POLD2 POLH POLI POLK RAD18 REV1 SOX12 SRM UBC UBE2B	O15370 P0CG48 P12004 P19623 P49005 P63146 Q14527 Q9NS91 Q9UBT6 Q9UBZ9 Q9UNA4 Q9Y253	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8172
	DDX3Y ELAVL1 HLTF PCNA POLH POLI POLK RAD18 REV1 RPAP1 UBC UBE2B	O15523 P0CG48 P12004 P63146 Q14527 Q15717 Q9BWH6 Q9NS91 Q9UBT6 Q9UBZ9 Q9UNA4 Q9Y253	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6402
	HLTF MAD2L2 PCNA POLH POLI POLK RAD18 REV1 REV3L UBC UBE2B	O60673 P0CG48 P12004 P63146 Q14527 Q9NS91 Q9UBT6 Q9UBZ9 Q9UI95 Q9UNA4 Q9Y253	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4554
	HLTF PCNA RAD18 RAD51 RAD54L RECQL4 RECQL5 SUMO2 UBC UBE2B UBE2I	O94761 O94762 P0CG48 P12004 P61956 P63146 P63279 Q06609 Q14527 Q92698 Q9NS91	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7839
	HLTF PCNA POLH POLI POLK RAD18 RAD51 RECQL4 RECQL5 REV1 UBC UBE2B UBE2I	O94761 O94762 P0CG48 P12004 P63146 P63279 Q06609 Q14527 Q9NS91 Q9UBT6 Q9UBZ9 Q9UNA4 Q9Y253	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7777

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blotting	2	40189497 38207106

Sequence, Structure & Domains

Sequences

Length

152

Mass

17,312

Sequence

MSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWNDS

3D Structural Models

Turn

47..50; 61..65; 93..95

Helix

4..18; 90..92; 102..113; 124..132; 134..147

Beta Strand

24..29; 32..41; 52..58; 69..74; 85..87

3D Structure

NMR spectroscopy (2); X-ray crystallography (2)

Domain & Motif Annotations

Domain (FT)

4..150; UBC core

Protein Families

Ubiquitin-conjugating enzyme family

Sequence Similarities

Belongs to the ubiquitin-conjugating enzyme family.

Clinical Relevance

Interaction Protein

ENSG00000070950ENSG00000155827ENSG00000159459

Interaction Count

3

Interaction Dataset

intact_biogrid

Entry name UBE2B	UniProt ID P63146	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification