Protein detail
UBE2B
Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B)
Entry name UBE2B | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 1 | Transmembrane count | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B)
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Cell SpecificLate spermatids
Function & Pathway
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component (8)
Molecular Function (5)
Biological Process (3)
Reactome (10)
- R-hsa-1280218 adaptive immune system
- R-hsa-983168 antigen processing ubiquitination proteasome degradation
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-73893 dna damage bypass
- R-hsa-73894 dna repair
- R-hsa-8866654 e3 ubiquitin ligases ubiquitinate target proteins
- R-hsa-597592 post translational protein modification
- R-hsa-8852135 protein ubiquitination
- R-hsa-110314 recognition of dna damage by pcna containing replication complex
- R-hsa-8866652 synthesis of active ubiquitin roles of e1 and e2 enzymes
Mediation Categories (3)
Immune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence37
Ligand-Receptor Signaling (7)
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Regulatory Interaction Network (8)
8 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:A0AVT1_P0CG47 | UBE2B | P63146 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:A0AVT1_P62979 | UBE2B | P63146 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:A0AVT1_P0CG48 | UBE2B | P63146 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:A0AVT1_P62987 | UBE2B | P63146 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P22314_P62979 | UBE2B | P63146 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P22314_P62987 | UBE2B | P63146 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P0CG47_P22314 | UBE2B | P63146 | Yes | Yes | SIGNOR | SIGNOR:34199813 | ||
| COMPLEX:P0CG48_P22314 | UBE2B | P63146 | Yes | Yes | SIGNOR | SIGNOR:34199813 |
Protein Complex Composition (21)
Sequence, Structure & Domains
Sequences
Length
152
Mass
17,312
Sequence
MSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWNDS
3D Structural Models
Turn
47..50; 61..65; 93..95
Helix
4..18; 90..92; 102..113; 124..132; 134..147
Beta Strand
24..29; 32..41; 52..58; 69..74; 85..87
3D Structure
NMR spectroscopy (2); X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
4..150; UBC core
Protein Families
Ubiquitin-conjugating enzyme family
Sequence Similarities
Belongs to the ubiquitin-conjugating enzyme family.
Clinical Relevance
Interaction Protein (3)
ENSG00000070950ENSG00000155827ENSG00000159459
Interaction Count
3
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 39136554 | Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation. | We find that Prom1 and Ttyh1 both induce formation of extracellular vesicles (EVs) in cultured mammalian cells and that the EVs produced are physically similar. |