Protein detail

F193A

Protein FAM193A (Protein IT14)

Entry name F193A	UniProt ID P78312	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein FAM193A (Protein IT14)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000125386

Entrez Gene Symbol

FAM193A

Gene Synonym (2)

C4orf8RES4-22

Gene Description

Family with sequence similarity 193 member A

Chromosome

Position

2536647-2732573

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Tissue SpecificliverCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway3

Protein Function

Predicted intracellular proteins

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence5

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	FAM193A MDM2 MDM4 PELI1 TP73	O15151 O15350 P78312 Q00987 Q96FA3	0:0:0:0:0	hu.MAP2
	FAM193A MDM4 PELI1	O15151 P78312 Q96FA3	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Polymer Precipitation	Western blotting	1	38731868

Sequence, Structure & Domains10

Sequences

Length

1,515

Mass

166,372

Sequence

MSPADAKRGAKRRKNKRGGGGGSGGGNGGASSGKAGPAAALRGSQAAGLAAPGSAAGLVGGAAAANGPLGAGASAGGAAPGGYFETPFSFGMNHRTPPYPAGDYCLLCRSERKDSSFLESGIKTASKLALSMAPKGNSVLHLPLWVCPDCRRTVEKEERHGGLDQPVSQDFLLHSSLGGSQPEAGSGGRLALGAQTLPSDTACSCEACSERREISAEADREPQQLQNYWSEVRYTVRCIYRQAGTPLADDQDQSLVPDKEGVKELVDRLCERDPYQLYQRLEQQAREYVLEMKVRLLRQLSAAAKVKAPSGLQGPPQAHQFISLLLEEYGALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCSEDTYSTLLQRYQRSEEELRRVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWELFKQRRFIEEQLTNKKAVTGENNFTDTMRHMLSSRLSMPDCPNCNYRRRCACDDCSLSHILTCGIMDPPVTDDIHIHQLPLQVDPAPDYLAERSPPSVSSASSGSGSSSPITIQQHPRLILTDSGSAPTFCSDDEDVAPLSAKFADIYPLSNYDDTEVVANMNGIHSELNGGGENMALKDESPQISSTSSSSSEADDEEADGESSGEPPGAPKEDGVLGSRSPRTEESKADSPPPSYPTQQAEQAPNTCECHVCKQEASGLTPSAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYATPPFTHSKALPPAPVQNHTNKHQVFNASLQDHIYPSCFGNTPEWNSSKFISLWGSEVMNDKNWNPGTFLPDTISGSEILGPTLSETRPEALPPPSSNETPAVSDSKEKKNAAKKKCLYNFQDAFMEANKVVMATSSATSSVSCTATTVQSSNSQFRVSSKRPPSVGDVFHGISKEDHRHSAPAAPRNSPTGLAPLPALSPAALSPAALSPASTPHLANLAAPSFPKTATTTPGFVDTRKSFCPAPLPPATDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMDQISERESVVDHRRVEDLLQFINSSETKPVSSTRAAKRARHKQRKLEEKARLEAEARAREHLHLQEEQRRREEEEDEEEEEDRFKEEFQRLQELQKLRAVKKKKKERPSKDCPKLDMLTRNFQAATESVPNSGNIHNGSLEQTEEPETSSHSPSRHMNHSEPRPGLGADGDAADPVDTRDSKFLLPKEVNGKQHEPLSFFFDIMQHHKEGNGKQKLRQTSKASSEPARRPTEPPKATEGQSKPRAQTESKAKVVDLMSITEQKREERKVNSNNNNKKQLNHIKDEKSNPTPMEPTSPGEHQQNSKLVLAESPQPKGKNKKNKKKKGDRVNNSIDDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQTRQRLSINWSNFSLKKATFAAH

Alternative Products

Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=P78312-7; Sequence=Displayed; Name=2; Synonyms=RES4-22B; IsoId=P78312-1; Sequence=VSP_062720, VSP_062725; Name=3; Synonyms=RES4-22A; IsoId=P78312-2; Sequence=VSP_062720; Name=4; Synonyms=RES4-22C; IsoId=P78312-3; Sequence=VSP_062720, VSP_062723, VSP_062724; Name=5; Synonyms=RES4-22D; IsoId=P78312-4; Sequence=VSP_062719, VSP_062725; Name=6; IsoId=P78312-5; Sequence=VSP_062720, VSP_062721, VSP_062722; Name=7; IsoId=P78312-6; Sequence=VSP_062720, VSP_062726, VSP_062727

Alternative Sequence

1..437; Missing (in isoform 5); 1..291; Missing (in isoform 3, isoform 2, isoform 6, isoform 7 and isoform 4); 437; Q -> QDLQTSVNKSIDTGTLVQSWLRGAA (in isoform 6); 583..584; Missing (in isoform 6); 1077..1083; GKYCDCC -> ASSCTNK (in isoform 4); 1084..1515; Missing (in isoform 4); 1457; I -> IDGVSLLLPSLGYNGAILAHCNLRLPGSSDCAASASQVVGIT (in isoform 2 and isoform 5); 1486..1502; FCLDSARQTRQRLSINW -> DGVSPHCPGWSRTPGLK (in isoform 7); 1503..1515; Missing (in isoform 7)

Domain & Motif Annotations

Compositional Bias

255..271; Low complexity; 355..365; Acidic residues; 757..769; Acidic residues; 772..781; Low complexity; 868..877; Basic residues; 893..905; Basic and acidic residues; 915..929; Basic and acidic residues; 931..940; Basic residues; 953..973; Polar residues; 1149..1159; Basic residues

Coiled Coil

398..433; 1164..1223; 1384..1409

Region

247..272; Disordered; 331..407; Disordered; 553..586; Disordered; 626..674; Disordered; 750..785; Disordered; 822..841; Disordered; 859..881; Disordered; 893..1163; Disordered

Protein Families

FAM193 family

Sequence Similarities

Belongs to the FAM193 family.

Clinical Relevance1

Antibody

HPA043116

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available