Protein detail
F193A
Protein FAM193A (Protein IT14)
Entry name F193A | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Protein FAM193A (Protein IT14)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
C4orf8RES4-22
Gene Description
Family with sequence similarity 193 member A
Chromosome
4
Position
2536647-2732573
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificliverCell SpecificAdrenal medulla cellsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence5
Ligand-Receptor Signaling (2)
2 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
1,515
Mass
166,372
Sequence
MSPADAKRGAKRRKNKRGGGGGSGGGNGGASSGKAGPAAALRGSQAAGLAAPGSAAGLVGGAAAANGPLGAGASAGGAAPGGYFETPFSFGMNHRTPPYPAGDYCLLCRSERKDSSFLESGIKTASKLALSMAPKGNSVLHLPLWVCPDCRRTVEKEERHGGLDQPVSQDFLLHSSLGGSQPEAGSGGRLALGAQTLPSDTACSCEACSERREISAEADREPQQLQNYWSEVRYTVRCIYRQAGTPLADDQDQSLVPDKEGVKELVDRLCERDPYQLYQRLEQQAREYVLEMKVRLLRQLSAAAKVKAPSGLQGPPQAHQFISLLLEEYGALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCSEDTYSTLLQRYQRSEEELRRVAEEWLECQKRIDAYVDEQMTMKTKQRMLTEDWELFKQRRFIEEQLTNKKAVTGENNFTDTMRHMLSSRLSMPDCPNCNYRRRCACDDCSLSHILTCGIMDPPVTDDIHIHQLPLQVDPAPDYLAERSPPSVSSASSGSGSSSPITIQQHPRLILTDSGSAPTFCSDDEDVAPLSAKFADIYPLSNYDDTEVVANMNGIHSELNGGGENMALKDESPQISSTSSSSSEADDEEADGESSGEPPGAPKEDGVLGSRSPRTEESKADSPPPSYPTQQAEQAPNTCECHVCKQEASGLTPSAMTAGALPPGHQFLSPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYATPPFTHSKALPPAPVQNHTNKHQVFNASLQDHIYPSCFGNTPEWNSSKFISLWGSEVMNDKNWNPGTFLPDTISGSEILGPTLSETRPEALPPPSSNETPAVSDSKEKKNAAKKKCLYNFQDAFMEANKVVMATSSATSSVSCTATTVQSSNSQFRVSSKRPPSVGDVFHGISKEDHRHSAPAAPRNSPTGLAPLPALSPAALSPAALSPASTPHLANLAAPSFPKTATTTPGFVDTRKSFCPAPLPPATDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDESADEDSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHGGPPAAPTSRNYAEMREKLRLRLTKRKEEQPKKMDQISERESVVDHRRVEDLLQFINSSETKPVSSTRAAKRARHKQRKLEEKARLEAEARAREHLHLQEEQRRREEEEDEEEEEDRFKEEFQRLQELQKLRAVKKKKKERPSKDCPKLDMLTRNFQAATESVPNSGNIHNGSLEQTEEPETSSHSPSRHMNHSEPRPGLGADGDAADPVDTRDSKFLLPKEVNGKQHEPLSFFFDIMQHHKEGNGKQKLRQTSKASSEPARRPTEPPKATEGQSKPRAQTESKAKVVDLMSITEQKREERKVNSNNNNKKQLNHIKDEKSNPTPMEPTSPGEHQQNSKLVLAESPQPKGKNKKNKKKKGDRVNNSIDDVFLPKDIDLDSVDMDETEREVEYFKRFCLDSARQTRQRLSINWSNFSLKKATFAAH
Alternative Products
Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=P78312-7; Sequence=Displayed; Name=2; Synonyms=RES4-22B; IsoId=P78312-1; Sequence=VSP_062720, VSP_062725; Name=3; Synonyms=RES4-22A; IsoId=P78312-2; Sequence=VSP_062720; Name=4; Synonyms=RES4-22C; IsoId=P78312-3; Sequence=VSP_062720, VSP_062723, VSP_062724; Name=5; Synonyms=RES4-22D; IsoId=P78312-4; Sequence=VSP_062719, VSP_062725; Name=6; IsoId=P78312-5; Sequence=VSP_062720, VSP_062721, VSP_062722; Name=7; IsoId=P78312-6; Sequence=VSP_062720, VSP_062726, VSP_062727
Alternative Sequence
1..437; Missing (in isoform 5); 1..291; Missing (in isoform 3, isoform 2, isoform 6, isoform 7 and isoform 4); 437; Q -> QDLQTSVNKSIDTGTLVQSWLRGAA (in isoform 6); 583..584; Missing (in isoform 6); 1077..1083; GKYCDCC -> ASSCTNK (in isoform 4); 1084..1515; Missing (in isoform 4); 1457; I -> IDGVSLLLPSLGYNGAILAHCNLRLPGSSDCAASASQVVGIT (in isoform 2 and isoform 5); 1486..1502; FCLDSARQTRQRLSINW -> DGVSPHCPGWSRTPGLK (in isoform 7); 1503..1515; Missing (in isoform 7)
Domain & Motif Annotations
Compositional Bias
255..271; Low complexity; 355..365; Acidic residues; 757..769; Acidic residues; 772..781; Low complexity; 868..877; Basic residues; 893..905; Basic and acidic residues; 915..929; Basic and acidic residues; 931..940; Basic residues; 953..973; Polar residues; 1149..1159; Basic residues
Coiled Coil
398..433; 1164..1223; 1384..1409
Region
247..272; Disordered; 331..407; Disordered; 553..586; Disordered; 626..674; Disordered; 750..785; Disordered; 822..841; Disordered; 859..881; Disordered; 893..1163; Disordered
Protein Families
FAM193 family
Sequence Similarities
Belongs to the FAM193 family.
Clinical Relevance
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |